Ischemic mitral regurgitation: Pathophysiology, diagnosis and surgical treatment

Expert Review of Cardiovascular Therapy

Volumn 4, Issue 6, 2006, Pages 827-838

  Paparella, Domenico ^a   Malvindi, Pietro Giorgio ^a   Romito, Roberta ^b   Fiore, Giuseppe ^b   Schinosa, Luigi de Luca Tupputi ^a  

^a UNIVERSITY OF BARI   (Italy)

^b POLICLINICO   (Italy)

Author keywords

Coronary artery disease; Echocardiography; Ischemic cardiomyopathy; Left ventricle remodeling; Mitral regurgitation; Mitral valve repair

Indexed keywords

ACUTE HEART INFARCTION; ANNULOPLASTY; CLINICAL TRIAL; COLOR ULTRASOUND FLOWMETRY; CONGESTIVE CARDIOMYOPATHY; CORONARY ARTERY BYPASS SURGERY; CORONARY REPERFUSION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE REVASCULARIZATION; HEART PAPILLARY MUSCLE; HEART VENTRICLE REMODELING; HUMAN; MEDICAL DECISION MAKING; MITRAL VALVE REGURGITATION; MITRAL VALVE REPLACEMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PERCUTANEOUS CORONARY INTERVENTION; PREOPERATIVE EVALUATION; PROGNOSIS; REVIEW; STRESS ECHOCARDIOGRAPHY; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TRANSTHORACIC ECHOCARDIOGRAPHY;

CORONARY ARTERY BYPASS; DIAGNOSIS, DIFFERENTIAL; ECHOCARDIOGRAPHY; HUMANS; MAGNETIC RESONANCE IMAGING; MITRAL VALVE INSUFFICIENCY; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REVASCULARIZATION; PROGNOSIS; VENTRICULAR REMODELING;

EID: 33845906665     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.4.6.827     Document Type: Review

References (85)

1. Liel-Cohen N, Guerrero JL, Otsuji Y et al. Design of a new surgical approach for ventricular remodeling to relieve ischemic mitral regurgitation. Insights from 3-dimensional echocardiography. Circulation 101, 2756-2763 (2000).
2. Levine RA, Messas E, Nathan NS, Rudski LG. New understanding of ischemic mitral regurgitation: the marionette and its masters. Eur. J. Echocardiography 5, 313-317 (2004).
3. Van Dantzig JM, Delemarre BJ, Koster RW, Rot H, Visser CA. Pathogenesis of mitral regurgitation in acute myocardial infarction: Importance of changes in left ventricular shape and regional function. Am. Heart J. 131, 865-871 (1996).
4. Kaul S, Spotnitz WD, Glasheen WP, Touchstone DA. Mechanism of ischemic mitral regurgitation. An experience evaluation. Circulation 84, 2167-2180 (1991).
5. Agricola E, Oppizzi M, Maisano F et al. Echocardiographic classification of chronic ischemic mitral regurgitation caused by restricted motion according to tethering pattern. Eur J. Echocardiography 5, 326-334 (2004).
6. Srichai MB, Grimm RA, Stillman AE et al. Ischemic Mitral Regurgitation: Impact of the Left Ventricle and Mitral Valve in Patients with Left Ventricular Systolic Dysfunction. Ann. Thorac. Surg. 80, 170-178 (2005).
7. Kumanohoso T, Otsuji Y et al. Mechanism of higher incidence of ischemic mitral regurgitation in patients with inferior myocardial infarction: quantitative analysis of left ventricular and mitral valve geometry in 103 patients with prior myocardial infarction. J. Thorac. Cardiovasc. Surg. 125, 135-143 (2003).
8. Timek TA, Lai DT, Tibayan F et al. Ischemia in three left ventricular regions: Insights into the pathogenesis of acute ischemic mitral regurgitation. J. Thorac. Cardiovasc. Surg. 125, 559-569 (2003).
9. Tibayan FA, Rodriguez F, Langer F et al. Annular remodeling in chronic ischemic mitral regurgitation: ring selection implications. Ann. Thorac. Surg. 76, 1549-1555 (2003).
10. Gorman JH III, Gorman RC, Jackson BM, Enomoto Y, St John-Sutton MG, Edmunds LH Jr. Annuloplasty ring selection for chronic ischemic mitral regurgitation: lessons from ovine model. Ann. Thorac. Surg. 76, 1556-1563 (2003).
11. Kwan J, Shiota T, Agler DA et al. Geometric differences of the mitral apparatus between ischemic and dilated cardiomyopathy with significant mitral regurgitation. Real-time three-dimensional echocardiography study. Circulation 107, 1135-1140 (2003).
12. Yu HS, Su MY, Liao TY, Peng HH, Lin FY, Tseng WYI. Functional mitral regurgitation in chronic ischemic coronary artery disease: Analysis of geometric alterations of mitral apparatus with magnetic resonance imaging. J. Thorac. Cardiovasc: Surg. 128, 543-551 (2004).
13. Grossman W, Dexter L. Profiles in valvular heart disease. In: Cardiac Catheterization and Angiography, Second Edition. Grossman W (Ed). Lea & Febiger, PA, USA, 305-324 (1980).
14. Gorman RC, Gorman JH, III, Edmunds LH Jr. Ischemic mitral regurgitation. In: Cardiac Surgery in the Adult (Chapter 28). Cohn LH (Ed.). McGraw Hill, New York, NY, USA, 751-769 (2003).
15. Helmcke F, Nanda NC, Hsiung MC et al. Color Doppler assessment of mitral regurgitation with orthogonal planes. Circulation 75, 175-183 (1987).
16. McCully, RB, Enriquez-Sarano M, Tajik AJ et al. Overestimation of severity of ischemic/functional mitral regurgitation by color Doppler jet area. Am. J. Cardiol. 74, 790-793 (1994).
17. Heinle SK, Hall SA, Brickner ME et al. Comparison of vena contracta width by multiplane transesophageal echocardiography with quantitative Doppler assessment of mitral regurgitation. Am. J. Cardiol. 81, 175-179 (1998).
18. Enriquez-Sarano M, Bailey KR, Seward JB et al. Quantitative Doppler assessment of vaivular regurgitation. Circulation 87, 841-848 (1993).
19. Enriquez-Sarano M, Miller FA, Hayes SN et al. Effective mitral regurgitant orifice area: clinical use and pitfalls of the proximal isovelocity surface area method. J. Am. Coll. Cardiol. 25, 703-709 (1995).
20. Grigioni F, Enriquez-Sarano M, Zehr KJ, Bailey KR, Tajik AJ. Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation 103, 1759-1764 (2001).
21. Bursi F, Enriquez-Sarano M, Jacobsen SJ, Roger VL. Mitral regurgitation after myocardial infarction: a review. Am. J. Med. 119, 103-112 (2006).
22. Calafiore AM, Gallina S, Di Mauro M et al. Mitral valve procedure in dilated cardiomyopathy: repair or replacement? Ann. Thorac. Surg. 71(4), 1146-1152 (2001).
23. Yiu SF, Enriquez-Sarano M, Tribouilloy C, Seward JB, Tajik AJ. Determinants of the degree of functional mitral regurgitation in patients with systolic left ventricular dysfunction a quantitative clinical study. Circulation 102, 1400-1406 (2000).
24. Wolf I, Mottl-Link S, Hoda R et al. A clinical study of annular geometry and dynamics in patients with ischemic mitral regurgitation: new insights into asymmetrical ring annuloplasty. Eur. J. Cardio-Thorac. Surg. 29, 355-361 (2006).
25. Watanabe N, Ogasawara Y, Yamaura Y et al. Quantitation of mitral valve tenting in ischemic mitral regurgitation by transthoracic real-time three-dimensional echocardiography. J. Am. Coll. Cardiol. 45, 763-769 (2005).
26. Watanabe N, Ogasawara Y, Yamaura Y, Kawamoto T, Akasaka T, Yoshida K. Geometric deformity of the mitral annulus in patients with ischemic mitral regurgitation: a real-time three-dimensional echocardiographic study. J. Heart Valve Dis. 14, 447-452 (2005).
27. Hung J, Papakostas L, Tahta SA et al. Mechanism of recurrent ischemic mitral regurgitation after annuloplasty continued Iv remodeling as a moving target. Circulation 110(Suppl. II), II-85-II-90 (2004).
28. Ereminiene E, Vaskelyte J. Benetis R, Stoskute N. Ischemic mitral valve repair: predictive significance of restrictive left ventricular diastolic filling. Echocardiograpby 22, 217-224 (2005).
29. Matsunaga. A, Tahta SA, Duran CM. Failure of reduction annuloplasty for functional ischemic mitral regurgitation. J. Heart Valve Dis. 13, 390-397 (2004).
30. Kaji S, Nasu M, Yamamuro A et al. annular geometry in patients with chronic ischemic mitral regurgitation-three-dimensional magnetic resonance imaging study. Circulation 112(Suppl. I) I-409-I-414 (2005).
31. Tunick PA, Freedberg RS, Gargiulo A, Kronzon I. Exercise Doppler echocardiography as an aid to clinical decision making in mitral valve disease. J. Am. Soc. Echocardiogr 5, 225-230 (1992).
32. Lancenotti P, Lebrun F, Pierard LA. Determinants of exercise induced changes in mitral regurgitation in patients with coronary artery disease and left ventricular dysfunction. J. Am. Coll. Cardiol. 42, 1921-1928 (2003).
33. Piérard LA and Lancenotti P. The role of ischemic mitral regurgitation in the pathogenesis of acute pulmonary edema. N. Engl. J. Med. 351, 1627-1634 (2004).
34. Lancellotti P, Troisfontaines P, Toussaint AC, Pierard LA. Prognostic importance of exercise-induced changes in mitral regurgitation in patients with chronic ischemic left ventricular dysfunction. Circulation 108, 1713-1717 (2003).
35. Heinle SK, Tice FD, Kisslo J. Effect of dobutamine stress echocardiography on mitral regurgitation. J. Am. Coll. Cardiol. 25, 122-127 (1995).
36. Roshanali F, Mandegar MH, Yousefnia MA, Alaeddini F, Wann S. Low-dose dobutamine stress echocardiography to predict reversibility of mitral regurgitation with CABG. Echocardiography 23(1), 31-36 (2006).
37. Hellemans IM, Pieper EG, Ravelli AC et al. Prediction of surgical strategy in mitral valve regurgitation based on echocardiography. Interuniversity Cardiology Institute of The Netherlands. Am. J. Cardiol. 79, 334-338 (1997).
38. Sheikh KH, Bengtson J R, Rankin J S, de Bruijn N P, Kisslo J. Intraoperative transesophageal Doppler color flow imaging used to guide patient selection and operative treatment of ischemic mitral regurgitation. Circulation 84, 594-604 (1991).
39. Schroder JN, Williams ML, Hata JA et al. Impact of mitral valve regurgitation evaluated by intraoperative transesophageal echocardiography on long-term outcomes after coronary artery bypass grafting. Circulation 112(9 Suppl.), 1293-1298 (2005).
40. Foster GP, Isselbacher EM, Rose GA. Accurate localization of mitral regurgitation defects using multiplane transesophageal echocardiography. Ann. Thorac. Surg. 65, 1025-1031 (1998).
41. Lambert AS, Miller JP, Merrick SH et al. improved evaluation of the location and mechanism of mitral valve regurgitation with a systematic transesophageal echocardiography examination. Anesth, Ana1g. 88, 1205-1212 (1999).
42. Fix J, Isada L, Cosgrove DM et al. Do patients with less than "echo-perfect" results from mitral valve repair by intraoperative echocardiography have a different outcome? Circulation 88, 39-48 (1993).
43. Yoshida K, Yoshikawa J, Yamaura Y, Hozumi T, Akasaka T, Fukaya T. Assessment of mitral regurgitation by biplane transesophageal color Doppler flow mapping. Circulation 82, 1121-1126 (1990).
44. Kawano H, Mizoguchi T, Aoyagi S. Intraoperative transesophageal echocardiography for evaluation of mitral valve repair. J. Heart Valve Dis 8, 287-293 (1999).
45. Saiki Y, Kasegawa H, Kawase M, Osada H, Ootaki E. Intraoperative TEE during mitral valve repair: does it predict early and late postoperative mitral valve dysfunction? Ann. Thorac. Surg. 66, 1277-1281 (1998).
46. Lehmann KG, Francis CK, Dodge HT and the TIMI Study Group. Mitral regurgitation in early myocardial Infarction. Incidence, clinical detection, and prognostic implication. Ann. Intern. Med. 117, 10-17 (1992).
47. Lamas GA, Mitchell GF, Flaker GC et al. Clinical significance of mitral regurgitation after acute myocardial infarction: survival and ventricular enlargement investigators. Circulation 96, 827-833 (1997).
48. Barzilai B, Gessler C, Perez JE, Schaab C, Jaffe AS. Significance of Doppler-detected mitral regurgitation in acute myocardial infarction. Am. J. Cardiol. 61, 220-223 (1988).
49. Feinberg MS, Schwammenthal E, Shlizerman L et al. Prognostic significance of mild mitral regurgitation by color Doppler echocardiography in acute myocardial infarction. Am. J. Cardiol. 86, 903-907 (2000).
50. Enriquez-Sarano M, Rossi A, Seward JB, Bailey KR, Tajik AJ. Determinants of pulmonary hypertension in left ventricular dysfunction. J. Am. Coll. Cardiol. 29, 153-159 (1997).
51. St. John Sutton M, Pfeffer MA, Plappert T et al. Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction: the protective effects of captopril. Circulation 89, 68-75 (1994).
52. King SB III, Koshiski AS, Guyton RA et al. Eight year mortality in the Emory Angioplasty versus Surgery Trial (EAST). J. Am. Coll. Cardiol. 35, 1116-1121 (2000).
53. The BARI Investigators. Seven-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status. J Am. Coll. Cardiol. 35, 1122-1129 (2000).
54. Ellis SG, Whitlow PL, Raymond RE, Shneider JP. Impact of mitral regurgitation on long-term survival after percutaneous coronary intervention. Am. J. Cardiol. 89, 315-318 (2002).
55. Pellizzon GG, Grines CL, Cox DA et al. Importance of mitral regurgitation inpatients undergoing percutaneous coronary intervention for acute myocardial infarction: the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. J Am. Coll. Cardiol. 43, 1368-1374 (2004).
56. Paparella D, Mickleborough LL, Carson S, Ivanov L. Mild to moderate mitral regurgitation in patients undergoing coronary bypass grafting: effects on operative mortality and long-term significance. Ann. Thorac. Surg. 76, 1094-1100 (2003).
57. Jacob N. Schroder JN, Williams ML et al. Impact of mitral valve regurgitation evaluated by intraoperative transesophageal echocardiography on long-term outcomes after coronary. artery bypass grafting Ciculation 112(Suppl. I,), I-293-I-298 (2005).
58. Lam BK, Gillinov AM, Blackstone EH et al. Importance of moderate ischemic mitral regurgitation. Ann. Thorac. Surg. 79(2), 462-470 (2005).
59. Mallidi HR, Pellettier ME Lamb J et al. Late outcomes in patients with uncorrected mild to moderate mitral regurgitation at the time of isolated coronary agtery bypass grafting. J. Thorac Cardiovasc. Surg. 127, 636-644
60. Aklog L, Filsoufi F, Flores KQ et al. Does coronary artery bypass grafting alone correct moderate ischemic mitral regurgitation? Circulation 104(Suppl. I), I-68-I-75 (2001).
61. Ryden T, Bech-Hanssen O, Brandrup-Wognsen G, Nilsson F, Svensson S, Jeppsson A. The importance of grade 2 ischemic mitral regurgitation in coronary artery bypass grafting. Eur. J. Cardiothorac Surg. 20, 276-281 (2001).
62. Grossi EA, Goldberg JD, LaPietra A et al. Ischemic mitral valve recostrunction and replacement. Comparison of long-term survival and complications. J. Thorac. Cardiovasc. Surg. 122, 1107-1124 (2001).
63. Gillinov AM, Wierup PN, Blackstone EH et al. Is repair preferable to replacement for ischemic mitral regurgitation? J. Thorac. Cardiovasc. Surg. 122, 1125-1141(2001).
64. Hendren WG, Nemec JJ, Bruce WL et al. Mitral valve repair for ischemic mitral insufficiency. Ann. Thorac. Surg. 52, 1246-1252 (1991).
65. Calafiore AM, Di Mauro M, Gallina, S et al. Mitral valve surgery for chronic ischemic regurgitation. Ann. Thorac. Surg. 77, 1989-1997 (2004).
66. McGee EG, Gillinov AM, Blackstone EH et al. Recurrent mitral regurgitation after annuloplasty for functional ischemic mitral regurgitation. J. Thorac. Cardiovasc. Surg. 128, 916-924 (2004).
67. Gillinov AM, Cosgrove III MD, Shiota T et al. Cosgrove-Edwards Annuloplasty System: midterm results. Ann. Thorac. Surg. 69, 717-721 (2000).
68. Dall'Agata A, Taams MA, Fioretti PM, Roelandt JRTC, Van Herwerden LA. Cosgrove-Edwards mitral ring dynamics measured with transesophageal three-dimensional echocardiography. Ann. Thorac. Surg. 65, 485-490 (1998).
69. Sharony R, Saunders PC, Nayar A et al. Semirigid partial annuloplasty band allows dynamic mitral annular motion and minimizes valvular gradients: an echocardiographic study. Ann. Thorac. Surg. 77, 518-522 (2004).
70. Tahta SA, Oury JH, Maxwell JM, Hiro SP, Duran CMG. Outcome after mitral valve repair for functional ischemic mitral regurgitation. J. Heart Valve Dis, 11, 11-19 (2002).
71. Boiling SF, Pagani FD, Deeb GM, Bach DS. Intermediate-term outcome of mitral reconstruction in cardiomyopathy. J. Thorac. Cardiovasc. Surg. 115, 381-388 (1998).
72. Daimon M, Fukuta S, Adams DH et al. Mitral valve repair with Carpentier-McCarthy-Adams IMR Etlogix annuloplasty ring for ischemic mitral regurgitation. Early echocardiographic results from a multi-center study. Circulation 114 (Suppl. I), I-588-I-593 (2006).
73. Zhu F, Otsuji Y, Yotsumoto G et al. Mechanism of persistent ischemic mitral regurgitation after annuloplasty. Importance of augmented posterior mitral leaflet tethering. Circulation 112(Suppl. I), I-396-I-401 (2005).
74. Tibayan FA, Rodriguez F, Langer F et al. Annular or subvalvular approach to chronic ischemic mitral regurgitation? J. Thorac Cardiovasc. Surg. 129, 1266-1275 (2005).
75. Messas E, Guerrero JL, Handsschumacher MD et al. Chordal cutting. A new therapeutic approach for Ischemic mitral regurgitation. Ciculation 104, 1958-1963 (2001).
76. Messas E, Pouzet B, Touchot B et al. Efficacy of chordal cutting to relieve chronic persistent ischemic mitral regurgitation. Circulation 108(Suppl. 1), II-111-II-115 (2003).
77. De Bonis M, Lapenna E, La Canna G et al. Mitral valve repair for functional mitral regurgitationin end-stage dilated cardiomyopathy. Role of the "edge-to-edge" technique. Circulation 112(Suppl. I), I-402-I-408 (2005).
78. Kincaid EH, Riley RD, Hines MH, Hammon JW, Kon ND. Anterior leaflet augmentation for ischemic mitral regurgitation. Ann. Thorac. Surg. 78, 564-568 (2004).
79. Matsui Y, Fukada Y, Naito Y, Sasaki S. Integrated overlapping ventriculoplasty combined with papillary muscle plication for severely dilated heart failure. J. Thorac Cardiovasc. Surg. 127, 1221-1223 (2004).
80. Ramadan R, Al-Attar N, Mohammadi S et al. Left ventricular infarct plication restores mitral function in chronic ischemic mitral regurgitation. J. Thorac. Cardiovasc. Surg. 129, 440-442 (2005).
81. Kron IL, Green GR, Cope JT Surgical relocation of the posterior papillary muscle in chronic ischemic mitral regurgitation. Ann. Thorac. Surg. 74, 600-601 (2002).
82. Maniu CV, Patel JB, Reuter DG et al. Acute and chronic reduction of functional mitral regurgitation in experimental heart failure by percutaneous mitral annuloplasty. J. Ann. Coll. Cardiol. 44, 1652-1661 (2004).
83. Webb JG, Harnek J, Munt BI et al. Percutaneous transvenous mitral annuloplasty: initial human experience with device implantation in the coronary sinus. Circulation 113, 851-855 (2006).
84. Wong DR, Agnihotri, AK, Hung JW et al. Long-term survival after surgical revascularization for moderate ischemic mitral regurgitation. Ann. Thorac. Surg. 80, 570-578 (2005).
85. Diodato MD, Moon MR, Pasque MK et al. Repair of ischemic mitral regurgitation does not increase mortality or improve long-term survival in patients undergoing coronary artery revascularization: a propensity analysis. Ann. Thorac. Surg. 78, 794-799 (2004).