Pathophysiological role of endothelin in ectopic ossification of human spinal ligaments induced by mechanical stress

Calcified Tissue International

Volumn 79, Issue 6, 2006, Pages 422-430

  Iwasawa, T ^a   Iwasaki, K ^a   Sawada, T ^a   Okada, A ^a   Ueyama, K ^b   Motomura, S ^a   Harata, S ^c   Inoue, I ^d   Toh, S ^a   Furukawa, K I ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b Hirosaki Memorial Hospital   (Japan)

^c AOMORI PREFECTURAL CENTRAL HOSPITAL   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Alkaline phosphatase; Bone morphogenetic protein; Endothelin; Ligament cell; Mechanical stress; Microarray; Ossification; Prostaglandin I2 synthase

Indexed keywords

ALKALINE PHOSPHATASE; ENDOTHELIN 1; MESSENGER RNA;

ARTICLE; AUTOCRINE EFFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIGAMENT CALCINOSIS; MARKER GENE; MECHANICAL STRESS; PARACRINE SIGNALING; PRIORITY JOURNAL; STRETCHING; UPREGULATION;

AGED; ALKALINE PHOSPHATASE; CALCINOSIS; CELLS, CULTURED; CERVICAL VERTEBRAE; ENDOTHELIN-1; ETHERS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; HYDROCARBONS, FLUORINATED; LONGITUDINAL LIGAMENTS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGOPEPTIDES; OSSIFICATION OF POSTERIOR LONGITUDINAL LIGAMENT; PIPERIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS, MECHANICAL; THORACIC VERTEBRAE;

EID: 33845894670     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-006-0147-7     Document Type: Article

References (31)

1. Baba H, Furusawa N, Fukuda M, Maezawa Y, Imura S, Kawahara N, Nakahashi K, Tomita K (1997) Potential role of streptozotocin in enhancing ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy). Eur J Histochem 41:191-202
2. Numasawa T, Koga H, Ueyama K, Maeda S, Sakou T, Harata S, Leppert M, Inoue I (1999) Human retinoic X receptor beta: complete genomic sequence and mutation search for ossification of posterior longitudinal ligament of the spine. J Bone Miner Res 14:500-508
3. Wang PN, Chen SS, Liu HC, Fuh JL, Kuo BI, Wang SJ (1999) Ossification of the posterior longitudinal ligament of the spine. A case-control risk factor study. Spine 24:142-144
4. Furushima K, Shimo-Onoda K, Maeda S, Nobukuni T, Ikari K, Koga H, Komiya S, Nakajima T, Harata S, Inoue I (2002) Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res 17:128-137
5. White AA, Panjabi MM (1990) Clinical Biomechanics of the Spine, 2nd ed. Lippincott-Raven, Philadelphia
6. Nakamura H (1994) A radiographic study of the progression of ossification of the cervical posterior longitudinal ligament: the correlation between the ossification of the posterior longitudinal ligament and that of the anterior longitudinal ligament. Nippon Seikeigeka Gakkai Zasshi 68:725-730
7. Takatsu T, Ishida Y, Suzuki K, Inoue H (1999) Radiological study of cervical ossification of the posterior longitudinal ligament. J Spinal Disord 12:271-273
8. Yamamoto Y, Furukawa K-I, Ueyama K, Nakanishi T, Takigawa M, Harata S (2002) Possible roles of CTGF/Hcs24 in the initiation and development of ossification of the posterior longitudinal ligament. Spine 27:1852-1857
9. Tanno M, Furukawa K-I, Ueyama K, Harata S, Motomura S (2003) Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments. Bone 33:475-484
10. 2 in the gene expression induced by mechanical stress in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament. J Pharmacol Exp Ther 305:818-824
11. Iwasaki K, Furukawa K-I, Tanno M, Kusumi T, Ueyama K, Tanaka M, Kudo H, Toh S, Harata S, Motomura S (2004) Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament. Calcif Tissue Int 74:448-457
12. Touyz RM, Schiffrin EL (2003) Role of endothelin in human hypertension. Can J Physiol Pharmacol 81:533-541
13. Yamazaki T, Komuro I, Kudoh S, Zou Y, Shiojima I, Hiroi Y, Mizuno T, Maemura K, Kurihara H, Akikawa R, Takano H, Yazaki Y (1996) Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. J Biol Chem 271:3221-3228
14. Dao HH, Essalihi R, Graillon JF, Lariviere R, De Champlain J, Moreau P (2002) Pharmacological prevention and regression of arterial remodeling in a rat model of isolated systolic hypertension. J Hypertens 20:1597-1606
15. Wu SY, Zhang BH, Pan CS, Jiang HF, Pang YZ, Tang CS, Qi YF (2002) Endothelin-1 is a potent regulator in vivo in vascular calcification and in vitro in calcification of vascular smooth muscle cells. Peptides 24:1149-1156
16. Sasaki T, Hong MH (1993) Endothelin-1 localization in bone cells and vascular endothelial cells in rat bone marrow. Anat Rec 237:332-337
17. Lodhi KM, Sakaguchi H, Hirse S, Shibabe S, Hagiwara H (1995) Perichondrial localization of ETA receptor in rat tracheal and xiphoid cartilage and in fetal rat epiphysis. Am J Physiol 268:C496-C502
18. Kasperk CH, Börscök I, Scairer HU, Schneider U, Nawroth PP, Niethard FU, Ziegler R (1997) Endothelin-1 is a potent regulator of human bone cell metabolism in vitro. Calcif Tissue Int 60:368-374
19. Kitano Y, Kurihara H, Kurihara Y, Maemura K, Ryo Y, Yazaki Y, Harii K (1998) Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization. J Bone Miner Res 13:237-244
20. Ikeda R, Yoshida K, Tsukahara S, Sakamoto Y, Tanaka H, Furukawa K-I, Inoue I (2005) The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1. J Biol Chem 280:8523-8530
21. Naruse K, Yamada T, Sokabe M (1998) Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch. Am J Physiol 274:H1532-H1538
22. Nicola CH, Libin J, Catherine CD, Emily MG, Clair AF (2000) A skeletal gene database. J Bone Miner Res 15:2095-2122
23. Sokolovsky M (1992) Structure-function relationships of endothelins, sarafotoxins, and their receptor subtypes. J Neurochem 59:809-821
24. Wada K, Tabuchi H, Ohba R, Satoh M, Tachibana Y, Akiyama N, Hiraoka O, Asakura A, Miyamoto C, Furuichi Y (1990) Purification of an endothelin receptor from human placenta. Biochem Biophys Res Commun 167:251-257
25. Yanagisawa M, Kurihara H, Kimura S, Goto K, Masaki T (1998) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-415
26. Takuwa Y (1993) Endothelin in vascular and endocrine systems: biological activities and its mechanisms of action. Endocr J 40:489-506
27. Harter LV, Hruska KA, Duncan RL (1995) Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormone regulation. Endocrinology 136:528-535
28. Koga H, Sakou T, Taketomi E, Hayashi K, Numasawa T, Harata S, Yone K, Matsunaga S, Otterud B, Inoue I (1998) Genetic mapping of ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 62:1460-1467
29. Tanaka T, Ikari K, Furushima K, Okada A, Tanaka H, Furukawa K-I, Yoshida K, Ikeda T, Ikegawa S, Hunt SC, Takeda J, Toh S, Harata S, Nakajima T, Inoue I (2003) Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 73:812-822
30. Beigi R, Kobatake E, Aizawa M, Dubyak GR (1999) Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase. Am J Physiol 276:C267-C278
31. Lodhi KM, Sakaguchi H, Hirse S, Shibabe S, Hagiwara H (1995) Perichondrial localization of ETA receptor in rat tracheal and xiphoid cartilage and in fetal rat epiphysis. Am J Physiol 268:C496-C502