Peripheral blood haematopoietic progenitor cells in patients with beta thalassaemia major receiving desferrioxamine or deferiprone as chelation therapy

European Journal of Haematology

Volumn 78, Issue 1, 2007, Pages 48-51

  Vlachaki, Efthimia ^a   Ioannidou Papagiannaki, Elissavet ^a   Tziomalos, Konstantinos ^b,c   Haralambidou Vranitsa, Styliani ^a   Perifanis, Vassilios ^b   Klonizakis, Ioannis ^a   Athanassiou Metaxa, Miranda ^b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Aristotle University of Thessaloniki   (Greece)

^c NONE   (Greece)

Author keywords

Beta thalassaemia; Chelation therapy; Deferiprone; Desferrioxamine; Granulocyte macrophage colony forming units; Granulocytic lineage; Neutropenia

Indexed keywords

DEFERIPRONE; DEFEROXAMINE;

ADULT; ARTICLE; BURST FORMING UNIT E; CELL CYCLE ARREST; CELL LINEAGE; CELL MATURATION; CHELATION THERAPY; CLINICAL ARTICLE; COLONY FORMING UNIT; COLONY FORMING UNIT G; COLONY FORMING UNIT GEMM; COLONY FORMING UNIT GM; COLONY FORMING UNIT M; CONTROLLED STUDY; FEMALE; HEMATOPOIETIC STEM CELL; HUMAN; MALE; NEUTROPENIA; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; THALASSEMIA MAJOR;

ADULT; BETA-THALASSEMIA; CHELATION THERAPY; DEFEROXAMINE; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; NEUTROPENIA; PYRIDONES; REFERENCE VALUES; TREATMENT OUTCOME;

EID: 33845885521     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2006.00773.x     Document Type: Article

References (9)

1. Maggio A, D'Amico G, Morabito A, et al. Deferiprone versus deferoxamine in patients with thalassemia major: a randomized clinical trial. Blood Cells Mol Dis 2002;28:196-208.
2. Ceci A, Baiardi P, Felisi M, et al. The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients. Br J Haematol 2002;118:330-6.
3. Pennell DJ, Berdoukas V, Karagiorga M, et al. Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. Blood 2006;107:3738-44.
4. Kralovics R, Prchal JT. Haematopoietic progenitors and signal transduction in polycythaemia vera and primary thrombocythaemia. Baillieres Clin Haematol 1998;11:803-18.
5. Chen JS, Lin KH, Tsao CJ. Peripheral blood hematopoietic progenitor cells in beta-thalassemia major. Int J Cell Cloning 1992;10:338-43.
6. Perlingeiro RC, Costa FF, Saad ST, Arruda VR, Queiroz ML. Spontaneous erythroid colony formation in Brazilian patients with sickle cell disease. Am J Hematol 1999;61:40-5.
7. Bincoletto C, Perlingeiro RC, Saad ST, Costa FF, Queiroz ML. Hydroxyurea promotes the reduction of spontaneous BFU-e to normal levels in SS and S/beta thalassemic patients. Hemoglobin 2001;25:1-7.
8. Le NTV, Richardson DR. Potent Iron Chelators Affect Multiple Genes Involved in the p53 Tumor Suppressor Pathway and Cell Cycle Control: A Gene Array Study. 13th International Conference on Oral Chelation in the Treatment of Thalassaemia and Other Diseases, July 12-15. Prague: SOSTE Notiziario: 2003:33.
9. Cunningham JM, al-Refaie FN, Hunter AE, Sheppard LN, Hoffbrand AV. Differential toxicity of alpha-keto hydroxypyridine iron chelators and desferrioxamine to human haemopoietic precursors in vitro. Eur J Haematol 1994;52:176-9.