Molecular pharmacological approach to drug actions on the afferent and efferent fibres of the vagal nerve involved in gastric mucosal protection in rats

Inflammopharmacology

Volumn 14, Issue 5-6, 2006, Pages 243-249

  Mózsik, Gyula ^a   Dömötör, András ^a   Abdel Salam, Ornar M E ^b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Afferent nerves; Capsaicin sensitive afferent nerves; Chemically induced gastric mucosal damage; Gastric basal and stimulated acid secretion; Vagal nerve

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; ATROPINE; BETHANECHOL; CAPSAICIN; CIMETIDINE; ESOMEPRAZOLE; FAMOTIDINE; HISTAMINE; HYDROCHLORIC ACID; INDOMETACIN; OMEPRAZOLE; PENTAGASTRIN; PIRENZEPINE; RANITIDINE; RESINIFERATOXIN; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BINDING AFFINITY; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; EFFERENT NERVE; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; STOMACH ACID; STOMACH ACID SECRETION; STOMACH LESION; STOMACH MUCOSA; STOMACH MUCOSA LESION; STOMACH SECRETION; VAGUS NERVE;

AFFERENT PATHWAYS; ANIMALS; ANTI-ULCER AGENTS; EFFERENT PATHWAYS; FEMALE; GASTRIC ACID; MALE; NERVE FIBERS; RATS; RATS, INBRED STRAINS; STOMACH; STOMACH ULCER; VAGUS NERVE;

EID: 33845865818     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-006-1548-y     Document Type: Conference Paper

References (15)

1. Abdel Salam, O. M. E., Debreceni, A. and Mózsik, Gy. (1999). Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxius agents. J. Physiol. 93, 443-454.
2. Abdel Salam, O. M. E., Czimmer, J., Debreceni, A. et al. (2001). Gastric mucosal integrity: Gastric mucosal blood flow and microcirculation. An overview. J. Physiol. 95, 105-127.
3. Djahanguiri, B. (1969). Production of acute gastric ulceration by indomethacin in the rat. Scand. J. Gastroenterol. 4, 265-267.
4. Holzer, P. (1998). Neural emergency system in the stomachs. Gastroenterology 114, 823-839.
5. Holzer, P. (1999). Capsaicin cellular targets. Mechanisms of action, as selectivity for thin sensory neurons. Pharmacol. Rev. 43, 143-201.
6. Mózsik, Gy., Moron, E, Jávor, T. (1982). Cellular mechanisms of the development of gastric mucosal damage and of gastroprotection induced by prostacyclin in rats. A pharmacological study. Prostagland. Leukot. Med. 9, 71-84.
7. Mózsik, Gy., Abdel-Salam, O. M. E., Szolcsányi, J. (1997). Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Damage and Protection. Akadémiai Kiadó: Budapest.
8. Mózsik, Gy., Pár, A., Pár G. et al. (2004a). Insights into the molecular pharmacology to drugs acting on the afferent and efferent fibres of vagal nerve in the gastric mucosal protection in: Ulcer Research, Proceedings of the 11th International Conference, Sikiri P., Seiwerth, P., Mózsik, Gy., Arakawa, T., Takeuchi, K. (Eds), pp. 163-168. Monduzzi: Bologna.
9. Mózsik, Gy., Belágyi, J., Szolcsányi, J. et al. (2004b). Capsaicin-sensitive afferent nerves and gastric mucosal protection on human healthy subjects. A critical overview, in: Mediators in Gastrointestinal Protection and Repair. Takeuchi, K. and Mózsik, Gy., (Eds), pp. 43-62. Research Signpost, Kerala, India.
10. Mózsik, Gy., Rácz, I., Szolcsányi, J. (2005). Gastroprotection induced by capsaicin in human healthy subjects. World J. Gastroenterol. 11, 5180-5184.
11. Mózsik, Gy. (2006). Molecular pharmacology and biochemistry of gastroduodenal mucosal damage and protection in: Discoveries in Gastroenterology: from Basic Research to Clinical Perspectives (1960-2005). Mózsik, Gy. (Ed), pp. 139-224. Akadémiai Kiadó, Budapest.
12. Robert, A., Nezamis, J. E., Lancaster, C., Hanchar, A. J. (1979). Cytoprotection by prostaglandins in rats. Prevention of gastric mucosal necrosis produced by alcohol, HCl, hypertonic NaCl. and thermal injury. Gastroenterology 77, 433-443.
13. Shay ,H., Komarow, S. A., Pels, S. S. et al.(1945). A simple method for the uniform production of gastric ulcer in the rats. Gastroenterology 5, 43-61.
14. Szállasi, A., Blumberg, M. (1999). Vanilloid (capsaicin) receptors and mechanisms. Phannacol. Re. 51, 159-211.
15. Szolcsányi, J. (2004). Forty years in capsaicin research for sensory pharmacology and physiology. Neuropeptide 38, 377-384.