Rapid analysis of acetaminophen in serum by gas chromatography-mass spectrometry with extractive derivatization using a diatomaceous earth tube

Forensic Toxicology

Volumn 24, Issue 2, 2006, Pages 65-69

  Hara, Kenji ^a   Kashimura, Seiichi ^a   Yanai, Tomoko ^a   Kashiwagi, Masayuki ^a   Miyoshi, Aya ^a   Kageura, Mitsuyoshi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

Acetaminophen; Diatomaceous eart; Extractive derivatization; GC MS; Heptafluorobutyryl; Serum

Indexed keywords

ANTIPYRETIC ANALGESIC AGENT; INFUSORIAL EARTH; METACETAMOL; PARACETAMOL;

ACCURACY; ADULT; ANALYTIC METHOD; ARTICLE; DERIVATIZATION; ELUTION; GAS CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; PH; PRIORITY JOURNAL; REPRODUCIBILITY; SERUM; STANDARD;

EID: 33845865538     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-006-0014-2     Document Type: Article

References (9)

1. Moffat AC, Osselton MD, Widdop B, Galichet LY (eds) (2004) Clarke's analysis of drugs and poisons, 3rd edn. Pharmaceutical, London, p 1391
2. Pistos C, Stewart JT (2004) Assay for the simultaneous determination of acetaminophen-caffeine-butalbital in human serum using a monolithic column. J Pharmaceut Biomed Anal 36:737-741
3. Jensen LS, Valentine J, Milne RW, Evans AW (2004) The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay. J Pharmaceut Biomed Anal 34:585-593
4. Matsumoto T, Sano T, Matsuoka T, Aoki M, Maeno Y, Nagao M (2003) Simultaneous determination of carisoprodol and acetaminophen in an attempted suicide by liquid chromatography-mass spectrometry with positive electrospray ionization. J Anal Toxicol 27:118-122
5. Song W, Dou C (2003) One-step immunoassay for acetaminophen and salicylate in serum, plasma, and whole blood. J Anal Toxicol 27:366-371
6. Speed DJ, Dickson SJ, Cairns ER, Kim ND (2001) Analysis of paracetamol using solid-phase extraction, deuterated internal standards, and gas chromatography-mass spectrometry. J Anal Toxicol 25:198-202
7. Hara K, Kashimura S, Hieda Y, Kageura M (1997) Simple extractive derivatization of methamphetamine and its metabolites in biological materials with Extrelut® columns for their GC-MS determination. J Anal Toxicol 21:54-58
8. Schulz M, Schmoldt A (2003) Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie 58:447-474
9. Gyamlani GT, Parikh CR (2002) Acetaminophen toxicity: suicidal vs accidental. Clin Care 6:155-159