Induction of apoptosis in HaCaT cells by photodynamic therapy with chlorin e6 or pheophorbide a

Skin Pharmacology and Physiology

Volumn 20, Issue 1, 2006, Pages 3-9

  Radestock, A ^a   Elsner, P ^a   Gitter, B ^b   Hipler, U C ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b Biolitec AG   (Germany)

Author keywords

Apoptosis; Caspases; HaCaT keratinocytes; Photodynamic therapy; Photosensitizers

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHLORIN E6; PHEOPHORBIDE A; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOLUMINESCENCE; CELL DEATH; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SENSITIVITY; DRUG UPTAKE; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PRIORITY JOURNAL; TOPICAL TREATMENT;

APOPTOSIS; CASPASE 3; CELLS, CULTURED; CHLOROPHYLL; HUMANS; KERATINOCYTES; PHOTOCHEMOTHERAPY; PORPHYRINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845802516     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000096166     Document Type: Article

References (32)

1. Moor ACE: Signaling pathways in cell death and survival after photodynamic therapy. J Photochem Photobiol B 2000;57:1-13.
2. Oleinick NL, Evans HH: The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat Res 1998;150(suppl):S146-S156.
3. Szeimies RM, Landthaler M, Karrer S: Non-oncologic indications for ALA-PDT. J Dermatolog Treat 2002;13(suppl 1):S13-S18.
4. Karrer S: Photodynamic therapy: non-oncologic indications. Akt Dermatol 2005;31:217-224.
5. Boehncke WH, Sterry W, Kaufmann R: Treatment of psoriasis by topical photodynamic therapy with polychromatic light. Lancet 1994;343:801.
6. Stringer MR, Collins P, Robinson DJ, Stables GI, Sheehan-Dare RA: The accumulation of protoporphyrin IX in plaque psoriasis after topical application of 5-aminolevulinic acid indicates a potential for superficial photodynamic therapy. J Invest Dermatol 1996;107:76-81.
7. Collins P, Robinson DJ, Stringer MR, Stables GI, Sheehan-Dare RA: The variable response of plaque psoriasis after a single treatment with topical 5-aminolevulinic acid photodynamic therapy. Br J Dermatol 1997;137:743-749.
8. Karrer S, Abels C, Landthaler M, Szeimies RM: Topical photodynamic therapy for localized scleroderma. Acta Derm Venereol 2000;80:26-27.
9. Jeffes EW, McCullough JL, Weinstein GD, Fergin PE, Nelson JS, Shull TF, Simpson KR, Bukaty LM, Hoffman WL, Fong NL: Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic acid. Arch Dermatol 1997;133:727-732.
10. Szeimies RM, Karrer S, Radakovic-Fijan S, Tanew A, Calzavara-Pinton PG, Zane C, Sidoroff A, Hempel M, Ulrich J, Proebstle T, Meffert H, Mulder M, Salomon D, Dittmar HC, Bauer JW, Kernland K, Braathen L: Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study. J Am Acad Dermatol 2002;47:258-262.
11. Piacquadio DJ, Chen DM, Farber HF, Fowler JF, Glazer SD, Goodman JJ, Hruza LL, Jeffes EWB, Ling MR, Phillips TJ, Rallis TM, Scher RK, Taylor CR, Weinstein GD: Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp. Arch Dermatol 2004;140:41-46.
12. Bachor R, Shea CR, Gillies R, Hasan T: Photosensitized destruction of human bladder carcinoma cells treated with chlorin e6-conjugated microspheres. Proc Natl Acad Sci USA 1991;88:1580-1584.
13. Gurinovich GP, Zorina TE, Melnov SB, Melnova NI, Gurinovich IF, Grubina LA, Sarzhevskaya MV, Cherenkevich SN: Photodynamic activity of chlorin e6 and chlorin e6 ethylenediamide in vitro and in vivo. J Photochem Photobiol B 1992;13:51-57.
14. Kostenich GA, Zhuravkin IN, Zhavrid EA: Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors. J Photochem Photobiol B Biol 1994;22:211-217.
15. Cunderlikova B, Gangeskar L, Moan J: Acid-base properties of chlorin e6: relation to cellular uptake. J Photochem Photobiol B Biol 1999;53:81-90.
16. Hajri A, Coffy S, Vallat F, Evrard S, Marescaux J, Aprahamian M: Human pancreatic carcinoma cells are sensitive to photodynamic therapy in vitro and in vivo. Br J Surg 1999;86:899-906.
17. Hajri A, Wack S, Meyer C, Smith MK, Leberquier C, Kedinger M, Aprahamian M: In vitro and in vivo efficacy of photofrin® and pheophorbide a, a bacteriochlorin, in photodynamic therapy of colonic cancer cells. Photochem Photobiol 2002;75:140-148.
18. Boyle RW, Dolphin D: Structure and biodistribution relationships of photodynamic sensitizers. Photochem Photobiol 1996;64:469-485.
19. Hipler U-C, Knöll B, Wollina U: The use of an ATP bioluminescence assay to quantify Ha-CaT cell cytotoxicity; in Roda A, Pazzagli M, Kricka LJ, Stanley PE (eds): Bioluminescence and Chemiluminescence. New York, Wiley, 1999, pp 169-172.
20. Xue L, He J, Oleinick NL: Promotion of photodynamic therapy-induced apoptosis by stress kinases. Cell Death Differ 1999;6:855-864.
21. Ahmad N, Gupta S, Feyes DK, Mukhtar H: Involvement of Fas (APO-1/CD-95) during photodynamic therapy-mediated apoptosis in human epidermoid carcinoma A 431 cells. J Invest Dermatol 2000;115:1041-1046.
22. Lam M, Oleinick NL, Nieminen AL: Photodynamic therapy-induced apoptosis in epidermoid carcinoma cells. J Biol Chem 2001;276:47379-47386.
23. Szeimies RM, Calzavara-Pinton PG, Karrer S, Ortel B, Landthaler M: Topical photodynamic therapy in dermatology. J Photochem Photobiol B 1996;36:213-219.
24. Karrer S, Bosserhoff AK, Weiderer P, Landthaler M, Szeimies RM: Influence of 5-aminolevulinic acid and red light on collagen metabolism of human dermal fibroblasts. J Invest Dermatol 2003;120:325-331.
25. Karrer S, Bosserhoff AK, Weiderer P, Landthaler M, Szeimies RM: Keratinocyte-derived cytokines after photodynamic therapy and their paracrine induction of matrix metalloproteinases in fibroblasts. Br J Dermatol 2004;151:776-783.
26. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988;106:761-771.
27. Dellinger M: Apoptosis or necrosis following photofrin® photosensitization: influence of the incubation protocol. Photochem Photobiol 1996;64:182-187.
28. Tanielian C, Kobayashi M, Wolff C: Mechanism of photodynamic activity of pheophorbides. J Biomed Optics 2001;6:252-256.
29. Kessel D, Luo Y, Deng Y, Chang CK: The role of subcellular localization in initiation of apoptosis by photodynamic therapy. Photochem Photobiol 1997;65:422-426.
30. Fabris C, Valduga G, Miotto G, Borsetto L, Jori G, Garbisa S, Reddi E: Photosensitization with zinc (II) phthalocyanine as a switch between apoptosis and necrosis. Cancer Res 2001;61:7495-7500.
31. Soukos NS, Hamblin MR, Hasan T: The effect of charge on cellular uptake and phototoxicity of polylysine chlorin e6 conjugates. Photochem Photobiol 1997;65:723-729.
32. Fernandez JM, Bilgin MD, Grossweiner LI: Singelt oxygen generation by photodynamic agents. J Photochem Photobiol B 1997;37:131-140.