Influence of consanguinity on the pattern of familial aggregation of congenital cardiovascular anomalies in an outpatient population: Studies from the Eastern Province of Saudi Arabia

Community Genetics

Volumn 10, Issue 1, 2006, Pages 27-31

  Seliem, Mohamed A ^a,b   Bou Holaigah, Issam H ^a   Al Sannaa, Nouriya ^a  

^a DHAHRAN HEALTH CENTER   (Saudi Arabia)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Congenital heart disease; Consanguinity

Indexed keywords

ARTICLE; CONGENITAL HEART MALFORMATION; CONGESTIVE CARDIOMYOPATHY; CONSANGUINEOUS MARRIAGE; CONSANGUINITY; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; OUTPATIENT; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SAUDI ARABIA; TERTIARY HEALTH CARE;

CARDIOVASCULAR ABNORMALITIES; CONSANGUINITY; FEMALE; HUMANS; MALE; OUTPATIENTS; PEDIGREE; POPULATION GROUPS; SAUDI ARABIA;

EID: 33845797021     PISSN: 14222795     EISSN: None     Source Type: Journal    
DOI: 10.1159/000096277     Document Type: Article

References (21)

1. Farag TI, Teebi AS: Genetic disorders among the Bedouins; in Teebi AS Farag TI (eds): Genetic Disorders among Arab Populations. New York, Oxford University Press, 1997, pp 375-410.
2. Becker S, Al Halees Z: First-cousin mating and congenital heart disease in Saudi Arabia. Community Genet 1999;2:69-73.
3. Hoess K, Goldmuntz E, Pyeritz RE: Genetic counseling for congenital heart disease. New approaches for a new decade. Curr Cardiol Rep 2002;4:68-75.
4. Digilio MC, Casey B, Toscano A, Calabro R, Pacileo G, Marasini M, Banaudi E, Giannotti A, Dallapicola B, Marino B: Complete transposition of the great arteries: patterns of congenital heart disease in familial precurrence. Circulation 2001;104:2809-2814.
5. Huntington K, Hunter AG, Chan KL: A perspective study to assess the frequency of familial clustering of congenital bicuspid aortic valve. J Am Coll Cardiol 1997;30:1809-1812.
6. Corone P, Bonaiti C, Feingold J, Fromont S, Berthet-Bondet D: Familial congenital heart disease. How are the various types related? Am J Cardiol 1983;51:942-945.
7. Goldmuntz E: Recent advances in understanding the genetic etiology of congenital heart disease. Curr Opin Pediatr 1999;11:437-443.
8. Seliem MA, Manasra KB, Pablea M, Ye X, Zhang Z, Benson DW: Evidence for autosomal recessive inheritance of infantile dilated cardiomyopathy: studies from the eastern province of Saudi Arabia. Pediatric Res 2000;48:770-775.
9. Becker S, Al-Halees Z, Molina C, Paterson RM: Consanguinity and congenital heart disease in Saudi Arabia. Am J Med Genet 2001;9:8-13.
10. Bassili A, Mokhtar SA, Dabous NI, Zaher SR, Mokhtar MM, Zaki A: Risk factors for congenial heart diseases in Alexandria, Egypt. Eur J Epidemiol 2000;16:805-814.
11. Roodpeyma S, Kamali Z, Afshar F, Naraghi S: Risk factors in congenital heart disease. Clin Pediatr (Phila) 2002;41:653-658.
12. Venugopalan P, Agarwal AK: Spectrum of congenital heart defects associated with Down syndrome in high consanguineous Omani population. Indian Pediatr 2003;40:398-404.
13. Henwood J, Pickard C, Leek JP, Bennett CP, Crow YJ, Thompson JD, Ahmed M, Watterson KG, Parsons JM, Roberts E, Lench NJ: A region of homozygosity within 22q11.2 associated with congenital heart disease: recessive DiGeorge/ velocariofacial syndrome? J Med Genet 2001;38:533-536.
14. Mani A, Meraji SM, Houshyar R, Radhakrishnan J, Mani A, Ahangar M, Rezaie T, Taghavinejad MA, Broumand B, Zhao H, Williams CN, Lifton RP: Finding genetic contribution to sporadic disease: a recessive locus at 12q24 commonly contributes to patent ductus arteriosus. Proc Natl Acad Sci USA 2002;99:15054-15059.
15. Maestri NE, Beaty TH, Liang KY, Boughman JA, Ferencz C: Assessing familial aggregation of congenital cardiovascular malformations in case-control studies. Genet Epidemiol 1988;5:343-354.
16. Boughman JA, Berg KA, Astemborski JA, Clark EB, McCarter RJ, Rubin JD, Ferencz C: Familial risks of congenital heart defect assessed in population-based epidemiologic study. Am J Med Genet 1987;26:839-849.
17. Digilio MC, Marino B, Canepa SA, Borzaga U, Giannotti A, Dallapiccola B: Congenital heart defect in sibs with discordant karyotypes. Am J Med Genet 1998;80:169-172.
18. Maestri NE, Bealy TH, Boughman JA: Etiologic heterogeneity in the familial aggregation of congenital cardiovascular malformations. Am J Hum Genet 1989;45:556-564.
19. Ferencz C, Boughman JA, Neil CA, Brenner JI, Perry LW: Congenital cardiovascular malformations: questions on inheritance. Baltimore-Washington infant study group. J Am Coll Cardiol 1989;14:756-763.
20. Nora JJ, Nora AH: Maternal transmission of congenital heart diseases: new recurrence risk figures and the question of cytoplasmic inheritance and vulnerability to teratogens. Am J Cardiol 1987;59:459-463.
21. Burn J, Brennan P, Little J, Holloway S, Coffey R, Somerville J, et al: Recurrence risks in offspring of adults with major heart defects: results from first cohort of British collaborative study. Lancet 1998;351:311-316.