Sensitivity of rabies virus to type i interferon is determined by the phosphoprotein gene

Microbiology and Immunology

Volumn 50, Issue 12, 2006, Pages 975-978

  Shimizu, Kenta ^a   Ito, Naoto ^a,b   Sugiyama, Makoto ^a   Minamoto, Nobuyuki ^a,b  

^a GIFU UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

Avirulent strain; Phosphoprotein; Rabies virus; Type I interferon

Indexed keywords

INTERFERON; PHOSPHOPROTEIN;

ARTICLE; CELL CLONING; CONTROLLED STUDY; NONHUMAN; RABIES VIRUS; SENSITIVITY ANALYSIS; VIROGENESIS; VIRUS STRAIN;

RABIES VIRUS;

EID: 33845759012     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2006.tb03875.x     Document Type: Article

References (16)

1. Blondel, D., Regad, T., Poisson, N., Pavie, B., Harper, F., Pandolfi, P.P., De The, H., and Chelbi-Alix, M.K. 2002. Rabies virus P and small P products interact directly with PML and reorganize PML nuclear bodies. Oncogene 21: 7957-7970.
2. Bonilla, W.V., Pinschewer, D.D., Klenerman, P., Rousson, V., Gaboli, M., Pandolfi, P.P., Zinkernagel, R.M., Salvato, M.S., and Hengartner, H. 2002. Effects of promyelocytic leukemia protein on virus-host balance. J. Virol. 76: 3810-3818.
3. Brzozka, K., Finke, S., and Conzelmann, K.K. 2006. Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2. J. Virol. 80: 2675-2683.
4. Chenik, M., Chebli, K., Gaudin, Y., and Blondel, D. 1994. In vivo interaction of rabies virus phosphoprotein (P) and nucleoprotein (N): existence of two N-binding sites on P protein. J. Gen. Virol. 75: 2889-2896.
5. Chenik, M., Schnell, M., Conzelmann, K.K., and Blondel, D. 1998. Mapping the interacting domains between the rabies virus polymerase and phosphoprotein. J. Virol. 72: 1925-1930.
6. Djavani, M., Rodas, J., Lukashevich, I.S., Horejsh, D., Pandolfi, P.P., Borden, K.L., and Salvato, M.S. 2001. Role of the promyelocytic leukemia protein PML in the interferon sensitivity of lymphocytic choriomeningitis virus. J. Virol. 75: 6204-6208.
7. Fu, Z.F., Zheng, Y., Wunner, W.H., Koprowski, H., and Dietzschold, B. 1994. Both the N- and the C-terminal domains of the nominal phosphoprotein of rabies virus are involved in binding to the nucleoprotein. Virology 200: 590-597.
8. Ito, N., Takayama-Ito, M., Yamada, K., Hosokawa, J., Sugiyama, M., and Minamoto, N. 2003. Improved recovery of rabies virus from cloned cDNA using a vaccinia virus-free reverse genetics system. Microbiol. Immunol. 47: 613-617.
9. Johnson, N., McKimmie, C.S., Mansfield, K.L., Wakeley, P.R., Brookes, S.M., Fazakerley, J.K., and Fooks, A.R. 2006. Lyssavirus infection activates interferon gene expression in the brain. J. Gen. Virol. 87: 2663-2667.
10. Mavrakis, M., McCarthy, A.A., Roche, S., Blondel, D., and Ruigrok, R.W. 2004. Structure and function of the C-terminal domain of the polymerase cofactor of rabies virus. J. Mol. Biol. 343: 819-831.
11. Minamoto, N., Tanaka, H., Hishida, M., Goto, H., Ito, H., Naruse, S., Yamamoto, K., Sugiyama, M., Kinjo, T., Mannen, K., and Mifune, K. 1994. Linear and conformation-dependent antigenic sites on the nucleoprotein of rabies virus. Microbiol. Immunol. 38: 449-455.
12. Pasdeloup, D., Poisson, N., Raux, H., Gaudin, Y., Ruigrok, R.W., and Blondel, D. 2005. Nucleocytoplasmic shuttling of the rabies virus P protein requires a nuclear localization signal and a CRM1-dependent nuclear export signal. Virology 334: 284-293.
13. Shimizu, K., Ito, N., Sugiyama, M., and Minamoto, N. 2006. Involvement of nucleoprotein, phosphoprotein, and matrix protein genes of rabies virus in virulence for adult mice. Virus Res. In press.
14. Vidy, A., Chelbi-Alix, M., and Blondel, D. 2005. Rabies virus P protein interacts with STAT1 and inhibits interferon signal transduction pathways. J. Virol. 79: 14411-14420.
15. Wang, Z.W., Sarmento, L., Wang, Y., Li, X.Q., Dhingra, V., Tseggai, T., Jiang, B., and Fu, Z.F. 2005. Attenuated rabies virus activates, while pathogenic rabies virus evades, the host innate immune responses in the central nervous system. J. Virol. 79: 12554-12565.
16. Yamada, K., Ito, N., Takayama-Ito, M., Sugiyama, M., and Minamoto, N. 2006. Multigenic relation to the attenuation of rabies virus. Microbiol. Immunol. 50: 25-32.