Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: Potential role in periodontal diseases

Journal of Ethnopharmacology

Volumn 109, Issue 2, 2007, Pages 325-330

  Zhu, Guangxun ^a,b   Li, Chengzhang ^a   Cao, Zhengguo ^a  

^a WUHAN UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Baicalin; Degranulation; Interleukin 8; Matrix metalloproteinase 8; Periodontal diseases

Indexed keywords

BAICALIN; FLAVONOID; INTERLEUKIN 8; NEUTROPHIL COLLAGENASE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL ISOLATION; CONCENTRATION RESPONSE; CULTURE MEDIUM; DEGRANULATION; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; PERIODONTAL DISEASE; SCUTELLARIA BAICALENSIS; TRANSMISSION ELECTRON MICROSCOPY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DEGRANULATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HUMANS; INTERLEUKIN-8; MICROSCOPY, ELECTRON, TRANSMISSION; NEUTROPHILS; PERIODONTAL DISEASES;

SCUTELLARIA BAICALENSIS;

EID: 33845741000     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.08.001     Document Type: Article

References (24)

1. Bickel M. The role of interleukin-8 in inflammation and mechanisms of regulation. Journal of Periodontology 64 (1993) 456-460
2. Birkedal-Hansen H., Moore W.G., Bodden M.K., Windsor L.J., Birkedal-Hansen B., DeCarlo A., and Engler J.A. Matrix metalloproteinases: a review. Critical Reviews in Oral Biology and Medicine 4 (1993) 197-250
3. Chung C.P., Park J.B., and Bae K.H. Pharmacological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. Planta Medica 61 (1995) 150-153
4. Dongari-Bagtzoglou A.I., and Ebersole J.L. Gingival fibroblast cytokine profiles in Actinobacillus actinomycetemcomitans-associated periodontitis. Journal of Periodontology 67 (1996) 871-878
5. Fitzgerald J.E., and Kreutzer D.L. Localization of interleukin-8 in human gingival tissues. Oral Microbiology and Immunology 10 (1995) 297-303
6. Gainet J., Chollet-Martin S., Brion M., Hakim J., Gougerot-Pocidalo M.A., and Elbim C. Interleukin-8 production by polymorphonuclear neutrophils in patients with rapidly progressive periodontitis: an amplifying loop of polymorphonuclear neutrophil activation. Laboratory Investigation 78 (1998) 755-762
7. Harada A., Mukaida N., and Matsushima K. Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases. Molecular Medicine Today 2 (1996) 482-489
8. Harbeck R.J., Hoffman A.A., Redecker S., Biundo T., and Kurnick J. The isolation and functional activity of polymorphonuclear leukocytes and lymphocytes separated from whole blood on a single percoll density gradient. Clinical Immunology and Immunopathology 23 (1982) 682-690
9. Huang X., Tu C.H.L., Zhang L.X., Dai J.R., and Jin Y.D. In: Huang Q., and Huang X. (Eds). Immunopharmacology (1986), Shanghai Science and Technology Press, Shanghai 159-160
10. Ingman T., Tervahartiala T., Ding Y., Tschesche H., Haerian A., Kinane D.F., Konttien Y.T., and Sorsa T. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. Journal of Clinical Periodontology 23 (1996) 1127-1132
11. Jepsen L.V., and Skottun T. A rapid one-step method for the isolation of human granulocytes from whole blood. Scandinavian Journal of Clinical and Laboratory Investigation 42 (1982) 235-238
12. Krakauer T., Li B.Q., and Young H.A. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. FEBS Letters 500 (2001) 52-55
13. Kubo M., Matsuda H., Tanaka M., Kimura Y., Okuda H., Higashino M., Tani T., Namba K., and Arichi S. Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix. Chemical & Pharmaceutical Bulletin 32 (1984) 2724-2729
14. Lee W., Aitken S., Sodek J., and McCulloch C.A. Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo role of active enzyme in human periodontitis. Journal of Periodontal Research 30 (1995) 23-33
15. Li B.Q., Fu T., Gong W.H., Dunlop N., Kung H., Yan Y., Kang J., and Wang J.M. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology 49 (2000) 295-306
16. Li C.Z., Cao Z.G., Yang R., Shang Z.H., Jin L.J., and Cobert E.F. Effects of baicalin on the expression of pro-MMP-1 and MMP-3 in human gingival fibroblasts and periodontal ligament cells. Chinese Journal of Stomatology 39 (2004) 197-200
17. Lin C.C., and Shieh D.E. The anti-inflammatory activity of Scutellaria rivularis extract and its active components, baicalin, baicalein and wogonin. The American Journal of Chinese Medicine 24 (1996) 31-36
18. Lo Y.C., Lin Y.L., Yu K.L., Lai Y.H., Wu Y.C., Ann L.M., and Chen I.J. San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs. Journal of Ethnopharmacology 101 (2005) 68-74
19. Miyasaki K.T. The neutrophil: mechanisms of controlling periodontal bacteria. Journal of Periodontology 62 (1991) 761-774
20. Murphy G., Reynolds J.J., Bretz U., and Baggiolini M. Collagenase is a component of the specific granules of human neutrophil leucocytes. The Biochemical Journal 162 (1977) 195-197
21. Romanelli R., Mancici S., Laschinger C., Overall C.M., Sodek J., and McCulloch C.A. Activation of neutrophil collagenase in periodontitis. Infection and Immunity 67 (1999) 2319-2326
22. Strober W. Common immunologic techniques: Trypan blue exclusion test of cell viability. In: Coligan J.E., Kruisbeek A.M., Margulies D.H., Shevach E.M., and Strober W. (Eds). Current Protocols in Immunology vol. 3 (1996), John Wiley, New York A.3B.1-2
23. Takashiba S., Takigawa M., Takahasi K., Myokai F., Nishimura F., Chihara T., Kurihara H., Nomura Y., and Murayama Y. Interleukin-8 is a major neutrophil chemotactic factor derived from cultured human gingival fibroblasts stimulated with interleukin-1 beta or tumor necrosis factor alpha. Infection and Immunity 60 (1992) 5253-5258
24. Van Den Steen P.E., Wuyts A., Husson S.J., Proost P., Van Damme J., and Opdenakker G. Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities. European Journal of Biochemistry 270 (2003) 3739-3749