Oxidative metabolism of seleno-L-methionine to L-methionine selenoxide by flavin-containing monooxygenases

Chemical Research in Toxicology

Volumn 19, Issue 12, 2006, Pages 1643-1649

  Krause, Renee J ^a   Glocke, Steven C ^a   Sicuri, Anna Rita ^a   Ripp, Sharon L ^a,b   Elfarra, Adnan A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYLIMIDAZOLE; BENZENE DERIVATIVE; COMPLEMENTARY DNA; DEFEROXAMINE; DIMETHYLANILINE MONOOXYGENASE; DNA; FLAVIN CONTAINING MONOOXYGENASE 3; FLAVIN CONTAINING MONOOXYGENASE 5; FLAVIN CONTAININH MONOOXYGENASE 1; METHIONINE DERIVATIVE; METHIONINE SELENOXIDE; NITRO DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENIUM DERIVATIVE; SELENOMETHIONINE; SUPEROXIDE DISMUTASE;

AEROBIC METABOLISM; ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; NONHUMAN; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SENSITIVITY AND SPECIFICITY; SYNTHESIS; TIME;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DINITROBENZENES; DNA, COMPLEMENTARY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLIC DETOXICATION, PHASE I; METHIONINE; MICROSOMES, LIVER; ORGANOSELENIUM COMPOUNDS; OXYGENASES; RATS; SELENOMETHIONINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33845735514     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0601915     Document Type: Article

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