Keratin 17/interferon-γ autoimmune loop as a vicious circle driving psoriasis pathogenesis

Journal of the American Academy of Dermatology

Volumn 56, Issue 1, 2007, Pages 162-

  Bonnekoh, Bernd ^a   Böckelmann, Raik ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 17; GAMMA INTERFERON; KERATIN; TUMOR NECROSIS FACTOR ALPHA;

AUTOIMMUNITY; CONCENTRATION (PARAMETERS); HUMAN; IMMUNOMODULATION; LETTER; PATHOGENESIS; PRIORITY JOURNAL; PSORIASIS; T LYMPHOCYTE;

AUTOANTIBODIES; AUTOIMMUNE DISEASES; FEEDBACK, BIOCHEMICAL; HUMANS; INTERFERON TYPE II; KERATIN-17; MODELS, IMMUNOLOGICAL; PSORIASIS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33845719517     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2006.07.034     Document Type: Letter

References (7)

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2. Flohr T., Buwitt U., Bonnekoh B., Decker T., and Böttger E.C. Interferon-γ regulates expression of a novel keratin class I gene. Eur J Immunol 22 (1992) 975-979
3. Bonnekoh B., Huerkamp C., Wevers A., Geisel J., Sebok B., Bange F.C., et al. Up-regulation of keratin 17 expression in human HaCaT keratinocytes by interferon-γ. J Invest Dermatol 104 (1995) 58-61
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6. Bonnekoh B., Böckelmann R., Ambach A., and Gollnick H. Dithranol and dimethylfumarate suppress the interferon-γ-induced up-regulation of cytokeratin 17 as a putative psoriasis autoantigen in-vitro. Skin Pharmacol Appl Skin Physiol 14 (2001) 217-225
7. Böckelmann R., Horn T., Gollnick H., and Bonnekoh B. Interferon-γ-dependent in-vitro-model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene-therapeutic effects. Skin Pharmacol Physiol 18 (2005) 42-54