Effects of pH on DU intake and removal by CBMIDA and EHBP

Health Physics

Volumn 92, Issue 1, 2007, Pages 10-14

  Fukuda, Satoshi ^a   Ikeda, Mizuyo ^a   Nakamura, Mariko ^a   Yan, Xueming ^b   Xie, Yuyuan ^b  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Actinides; Chelation; Health effects; Uranium, depleted

Indexed keywords

CATECHOL 3,6 BIS(METHYLENEIMINODIACETIC ACID); CHELATING AGENT; DEPLETED URANIUM; ETHANE 1 HYDROXY 1,1 BISPHOSHONATE; RADIOACTIVE MATERIAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHELATION; CONCENTRATION (PARAMETERS); CONTAMINATION; CONTROLLED STUDY; DATA ANALYSIS; KIDNEY DISEASE; MALE; NEPHROTOXICITY; NONHUMAN; PH; PRIORITY JOURNAL; RADIOACTIVITY; RAT; URINARY EXCRETION;

ANIMALS; CATECHOLS; CHELATING AGENTS; DIPHOSPHONATES; DOSE-RESPONSE RELATIONSHIP, RADIATION; FECES; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAPERITONEAL; MALE; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; RADIATION-PROTECTIVE AGENTS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION; URANIUM;

RATTUS NORVEGICUS;

EID: 33845689600     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.HP.0000228931.61447.b3     Document Type: Article

References (22)

1. Billard I, Ansoborlo E, Apperson K, Arpigny S, Azenha ME, Birch D, Bros P, Burrows HD, Choppin G, Couston L, Dubois V, Fanghanel T, Geipei G, Hubert S, Kim JI, Kimura T, Klenze R, Kronenberg A, Kumke M, Lagarde G, Lamarque G, Lis S, Madic C, Meinrath G, Moulin C, Nagaishi R, Parker D, Plancque G, Scherbaum F, Simoni E, Sinkov S, Viallesoubranne C. Aqueous solutions of uranium (VI) as studied by time-resolved emission spectroscopy: a round-robin test. Applied Spectroscopy 57:1027-1038; 2003.
2. Fukuda S. Chelating agents used for plutonium and uranium removal in radiation emergency medicine. Curr Med Chem 12:2765-2770; 2005.
3. Fukuda S, Iida H, Hseih Y, Chen W. Toxicological study of DTPA as a drug (V): toxicities of Ca-DTPA, Ca-EDTA and CBMIDA after intravenous injection in beagle dogs. Hoken Butsuri 25:115-119; 1990.
4. Fukuda S, Iida H, Hseih Y, Chen W. Toxicological study of DTPA as a drug (VI): effects of intravenously injected Ca-DTPA, Ca-EDTA, CBMIDA and orally administered Zn-DTPA to bone metabolism in beagle dogs. Hoken Butsuri 26:101-107; 1991.
5. Fukuda S, Iida H, Yan Y, Xie Y. Effects of CBMIDA on removal of uranium in rats. Biomarkers Environ 4(Suppl 1):35-37; 2001.
6. Fukuda S, Iida H, Yan X, Xie Y. Effects of CBMIDA and EHBP on removal of uranium and the side effects in rats. Biomarkers Environ 5:17-20; 2004a.
7. Fukuda S, Iida H, Yan X, Xie Y. Effects of long-term orally administered Zn-DTPA and CBMIDA on plutonium-induced cancers and shortening of life span in rats. Biomarkers Environ 5:14-16; 2004b.
8. Fukuda S, Iida H, Ikeda M, Yan X, Xie Y. Toxicity of uranium and the removal effects of CBMIDA and EHBP in simulated wounds of rats. Health Phys 89:81-88; 2005.
9. Fukuda S, Ikeda M, Chiba M, Kaneko K. Clinical diagnostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium. Radiat Prot Dosim 18:307-314; 2006.
10. Henge-Napoli MH, Archimbaud M, Ansoborlo E, Metivier H, Gourmelon P. Efficacy of 3,4,3-LIHOPO for reducing the retention of uranium in rat after acute administration. Int J Radiat Biol 68:389-393; 1995.
11. Henge-Napoli MH, Ansoborlo E, Chazei V, Houpert P, Paquest F, Gourmelon P. Efficacy of ethane-1-hydroxy-1,1-bisphosphonate (EHBP) for the decorporation of uranium after intramuscular contamination in rats. Int J Radiat Biol 75:1473-1477; 1999.
12. Hooper FJ, Squibb KS, Siegel EL, McPhaul K, Keogh JP. Elevated urine uranium excretion by soldiers with retained uranium shrapnel. Health Phys 77:512-519; 1999.
13. Jacopin C, Sawicki M, Plancque G, Doizi D, Taran F, Ansoborlo E, Amekraz B, Moulin C. Investigation of the interaction between 1-hydroxyethane-1, 1′-diphosponic acid (EHDP) and uranium (VI). Inorg Chem 42:5015-5022; 2003.
14. Martinez AB, Cabrini RL, Ubios AM. Orally administered ethane-1-hydroxy-1,1-bisphosphonate reduces the lethal effects of oral uranium poisoning. Health Phys 78:668-671; 2000.
15. Martinez AB, Mandalunis PM, Bozal CB, Carbrini RL, Ubios AM. Renal function in mice poisoned with oral uranium and treated with ethane-1-hydroxy-1,1-bisphosphonate (EHBP). Health Phys 85:343-347; 2003.
16. Moll H, Denecke MA, Jalilehvand F, Sandstrom M, Grenthe I. Structure of the aqua ions and fluoride complexes of uranium(IV) and thorium(IV) in aqueous solution: an EXAFS study. Inorg Chem 38:1795-1799; 1999.
17. Moulin C, Laszak I, Moulin V, Tondre C. Time-resolved laser-induced fluorescence as a unique tool for low-level uranium speciation. Applied Spectoroscopy 52:528-535; 1998.
18. Sawicki M, Siaugue JM, Jacopin C, Moulin C, Bailly T, Burgada R, Meunier S, Baret P, Pierre JL, Taran F. Discovery of powerful uranyl ligands from efficient synthesis and screening. Chem Eur J 11:3689-3697; 2005.
19. Szabo Z, Grenthe I. Potentiometric and multinuclear NMR study of the binary and ternary uranium(VI)-L-fluoride system, where L is alpha-hydroxycarboxylate or glycine. Inorg Chem 39:5036-5043; 2000.
20. Ubios AM, Braun EM, Cabrini RL. Lethality due to uranium poisoning is prevented by ethane-1-hydroxy-1,1-bisphosphonate (EHBP). Health Phys 66:540-544; 1994.
21. Vallet V, Wahlgren U, Schimmelpfennig B, Moll H, Szabo Z, Grenthe I. Solvent effects on uranium(VI) fluoride and hydroxide complexes studied by EXAFS and quantum chemistry. Inorg Chem 40:3516-3525; 2001.
22. Volf V. Optimisation and status of chelation therapy. Radiat Protect Dosim 26:331-335; 1989.