Thiazolidinediones may not reduce diabetes incidence in type 1 diabetes

Annals of the New York Academy of Sciences

Volumn 1079, Issue , 2006, Pages 365-368

  Shigihara, Toshikatsu ^a   Okubo, Yoshiaki ^a   Kanazawa, Yasuhiko ^a   Oikawa, Yoichi ^a   Shimada, Akira ^a,b  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE   (Japan)

Author keywords

Metformin; NOD (non obese diabetic) mouse; Slowly progressive insulin dependent diabetes mellitus (SPIDDM); Thiazolidinedione

Indexed keywords

CYCLOPHOSPHAMIDE; CYTOKINE; GAMMA INTERFERON; GLITAZONE DERIVATIVE; INTERLEUKIN 10; INTERLEUKIN 4; METFORMIN; PIOGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; FEMALE; GLYCEMIC CONTROL; IMMUNOPHARMACOLOGY; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INSULITIS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; SCORING SYSTEM; SPLEEN CELL; TH1 CELL; TH2 CELL;

EID: 33845688213     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1375.056     Document Type: Conference Paper

References (5)

1. BEALES, P.E. & P. POZZILLI. 2002. Thiazolidinediones for the prevention of diabetes in the non-obese diabetic (NOD) mouse: implications for human type 1 diabetes. Diabetes Metab. Res. Rev. 18: 114-117.
2. AUGSTEIN, P., A. DUNGER, et al. 2003. Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-g expression in splenic T cells. Biochem. Biophys. Res. Commun. 304: 378-384.
3. SHIGIHARA, T., A. SHIMADA, et al. 2005. CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice. J. Immunol. 75: 8401-8408.
4. GIORGINI, A.E., P.E. BEALES, et al. 1999. Troglitazone exhibits immunomodulatory activity on the cytokine production of activated human lymphocytes. Horm. Metab. Res. 31: 1-4.
5. BEALES, P.E., A.E. GIORGINI, et al. 1997. Metformin does not alter diabetes incidence in the NOD mouse. Horm. Metab. Res. 29: 261-263.