Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells

Biotechnology Letters

Volumn 29, Issue 1, 2007, Pages 141-147

  Shim, Eunsook ^a   Lee, Yun Sil ^b   Kim, Hae Yeong ^c   Jeoung, Dooil ^a  

^a Kangwon National University   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c Kyung Hee University   (South Korea)

Author keywords

C FLIP; Motility; Reactive oxygen species; Serine threonine kinase Akt

Indexed keywords

CELL CULTURE; ENZYMES; RNA; TUMORS;

C-FLIP; MOTILITY; REACTIVE OXYGEN SPECIES; SERINE/THREONINE KINASE AKT;

CELLS;

CFLAR PROTEIN, HUMAN; FLICE INHIBITORY PROTEIN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL MOTION; DOWN REGULATION; HELA CELL; HUMAN; METABOLISM; PHOSPHORYLATION;

CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL MOVEMENT; DOWN-REGULATION; HELA CELLS; HUMANS; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES;

EID: 33845670464     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-006-9213-5     Document Type: Article

References (15)

1. Aoudjit A, Vuori K (2001) Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J Cell Biol 152(3):633-643
2. Bae Y, Kang S, Seo M, Baines I, Tekle E, Chock P, Rhee S (1997) J Biol Chem 272(1):217-221
3. Bin L, Li X, Xu L, Shu H (2002) The short splice form of Casper/c-FLIP is a major cellular inhibitor of TRAIL-induced apoptosis. FEBS Lett 510(1-2):37-40
4. Brooks P, Montgomery A, Rosenfeld M, Reisfeld R, Hu T, Klier G, Cheresh D (1994) Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79(7):1157-1164
5. Desideri G, Bravi M, Tucci M, Croce G, Marinucci M, Santucci A, Alesse E, Ferri C (2003) Angiotensin II inhibits endothelial cell motility through an AT1-dependent oxidant-sensitive decrement of nitric oxide availability. Arterioscler Thromb Vasc Biol 23(7):1218-1223
6. Grassi F, Piacentini A, Cristino S, Toneguzzi S, Facchini A, Lisignoli G (2004) Inhibition of CD95 apoptotic signaling by interferon-gamma in human osteoarthritic chondrocytes is associated with increased expression of FLICE inhibitory protein. Arthritis Rheum 50(2):498-506
7. Huang R, Wu J, Fan Y, Adamson E (1996) UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol 133(1):211-220
8. Keisari Y (1992) A colorimetric microtiter assay for the quantitation of cytokine activity on adherent cells in tissue culture. J Immunol Methods 146:151-161
9. Lee S, Kim H, Kim S, Lee Y, Park W, Kim S, Lee J, Yoo N (2003) Increased expression of FLIP, an inhibitor of Fas-mediated apoptosis, in stomach cancer. APMIS 111(2):309-314
10. Mathas S, Lietz A, Anagnostopoulos I, Hummel F, Wiesner B, Janz M, Jundt F, Hirsch B, Johrens-Leder K, Vornlocher H, Bommert K, Stein H, Dorken B (2004) c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis. J Exp Med 199(8):1041-1052
11. Ohba M, Shibanuma M, Kuroki T, Nose K (1994) Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells. J Cell Biol 126(4):1079-1088
12. Rippo M, Moretti S, Vescovi S, Tomasetti M, Orecchia S, Amici G, Catalano A, Procopio A (2004) FLIP overexpression inhibits death receptor-induced apoptosis in malignant mesothelial cells. Oncogene 23(47):7753-7760
13. You Z, Ouyang H, Lopatin D, Polver P, Wang C (2001) Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity. J Biol Chem 276(28):26398-26404
14. Sattler M, Verma S, Shrikhande G, Byrne CH, Pride YB, Winkler T, Greenfield EA, Salgia R, Griffin J (2000) The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem 275(32):24273-24278
15. Sethi T, Rintoul RC, Moore SM, MacKinnon AC, Salter D, Choo C, Chilvers ER, Dransfield I, Donnelly SC, Strieter R, Haslett C (1999) Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med 5(6):662-668