Meta-analyses of studies of 0.2% delmopinol mouth rinse as an adjunct to gingival health and plaque control measures

Journal of Clinical Periodontology

Volumn 34, Issue 1, 2007, Pages 58-65

  Addy, Martin ^a   Moran, John ^a   Newcombe, Robert G ^b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Bleeding; Delmopinol; Gingivitis; Meta analysis; Plaque

Indexed keywords

DELMOPINOL; MORPHOLINE DERIVATIVE; PLACEBO;

ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; GINGIVA BLEEDING; GINGIVITIS; HUMAN; META ANALYSIS; METHODOLOGY; MOUTH HYGIENE; PERIODONTICS; RANDOMIZED CONTROLLED TRIAL; TIME; TOOTH PLAQUE; TREATMENT OUTCOME;

DENTAL PLAQUE; DENTAL PLAQUE INDEX; DOUBLE-BLIND METHOD; GINGIVAL HEMORRHAGE; GINGIVITIS; HUMANS; MORPHOLINES; MOUTHWASHES; PERIODONTAL INDEX; PLACEBOS; RANDOMIZED CONTROLLED TRIALS; RESEARCH DESIGN; TIME FACTORS; TREATMENT OUTCOME;

EID: 33845663708     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2006.01013.x     Document Type: Article

References (29)

1. Addy, M. (2003) The use of antiseptics in periodontal therapy. In: Lindhe, J., Karring, T. & Lang, K. (eds). Clinical Periodontology and Implant Dentistry, pp. 464-493. Oxford, UK: Blackwell Munksgaard.
2. Addy, M. & Newcombe, R. G. (2005) Statistical versus clinical significance in periodontal research and practice. Periodonotology 2000 39, 132-144.
3. Attström, R., Glantz, P.-O., Collaert, B. & Simonsson, T. (1992) Chemical plaque control by surface-active substances. In: Embery, G. & Rolla, G. (eds). Clinical and Biological Aspects of Dentifrices, pp. 263-275. Oxford, UK: Oxford University Press.
4. Bergenholtz, A., Kulstad, S. & Åström, M. (1993) Efficacy and safety of supervised rinsing with Decapinol mouthwash 1 mg/ml and 2 mg/ml compared to placebo in patients with gingivitis. Biosurface internal report AND-0361.
5. Claydon, N., Hunter, L., Moran, J., Wade, W., Kelty, E., Movert, R. & Addy, M. (1996) A 6-month home-usage trial of 0.1% and 0.2% delmopinol mouthwashes. 1. Effects on plaque, gingivitis, supragingival calculus and tooth staining. Journal of Clinical Periodontology 23, 220-228.
6. Collaert, B., Attstrom, R., de Bruyn, N. & Movert, R. (1992) The effect of delmopinol rinsing on dental plaque formation and gingivitis healing. Journal of Clinical Periodontology 19, 274-280.
7. Council on Dental Therapeutics. (1985) Guidelines for acceptance of chemotherapeutic products for the control of supragingival dental plaque and gingivitis. Journal of the American Dental Association 112, 529-532.
8. Davies, R. M., Ellwood, R. P. & Davies, G. M. (2004) The effectiveness of a toothpaste containing triclosan and polyvinyl-methyl ether maleic acid copolymer in improving plaque control and gingival health. A systematic review. Journal of Clinical Periodontology 31, 1029-1033.
9. Elworthy, A. J., Edgar, R., Moran, J., Movert, R., Kelty, E. & Wade, W. G. (1995) A 6-month home use trial of 0.1% and 0.2% delmopinol mouthwashes. II. Effects on the plaque microflora. Journal of Clinical Periodontology 22, 527-532.
10. Flotra, L., Gjermo, P., Rolla, G. & Waerhaug, J. (1971) Side effects of chlorhexidine mouthwashes. Scandinavian Journal of Dental Research 79, 119-125.
11. Hase, J. C., Ainamo, J., Etemadzadeh, H. & Astrom, M. (1995a) Plaque formation and gingivitis after mouthrinsing with 0.2% delmopinol hydrochloride, 0.2% chlorhexidine digluconate and placebo for 4 weeks, following an initial professional cleaning. Journal of Clinical Periodontology 22, 533-539.
12. Hase, J. C., Attstrom, R., Edwardsson, S., Kelty, E. & Kirsch, J. (1998a) 6-month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo. (1) Effect on plaque formation and gingivitis. Journal of Clinical Periodontology 25, 746-753.
13. Hase, J. C., Edwardsson, S., Rundegren, J., Edwardsson, S., Attstrom, R. & Kelty, E. (1998b) 6-month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo. (II) Effect on plaque and salivary microflora. Journal of Clinical Periodontology 25, 841-849.
14. Hase, J. C., Soder, P. O., Soder, B., Kulstad, S. & Kelty, E. (1995b) Development of plaque and gingivitis after rinsing with 0.2% delmopinol hydrochloride. European Journal of Oral Sciences 103, 172-178.
15. Hedges, L. V. & Olkin, I. (1985) Statistical Methods for Meta-analysis. Orlando, FL: Academic Press.
16. Jenkins, S., Addy, M. & Wade, W. (1988) The mechanism of action of chlorhexidine: a study of plaque growth on enamel inserts in vivo. Journal of Clinical Periodontology 15, 415-424.
17. Jones, C. G. (1997) Chlorhexidine: is it still the gold standard? Periodontology 2000 15, 55-62.
18. Lang, N. P., Hase, J. C., Grassi, M., Hammerle, C. H., Weigel, C., Kelty, E. & Frutig, F. (1995). Report of study DEC-90014. Pharmacia document AND-0377.
19. Lang, N. P., Hase, J. C., Grassi, M., Hammerle, C. H., Weigel, C., Kelty, E. & Frutig, F. (1998) Plaque formation and gingivitis after supervised mouthrinsing with 0.2% delmopinol hydrochloride, 0.2% chlorhexidine digluconate and placebo for 6 months. Oral Diseases 4, 105-113.
20. Lobene, R. R., Weatherford, T., Ross, N. M., Lamm, R. A. & Menaker, L. (1986) A modified gingival index for use in clinical trials. Clinical Preventive Dentistry 8, 3-6.
21. Löe, H. & Schiott, C. R. (1970) The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. Journal of Periodontal Research 5, 79-83.
22. Moran, J., Addy, M., Wade, W. G., Maynard, J. H., Roberts, S. E., Astrom, M. & Movert, R. (1992) A comparison of delmopinol and chlorhexidine on plaque regrowth over a 4-day period and salivary bacterial counts. Journal of Clinical Periodontology 19, 749-753.
23. Quigley, G. & Hein, J. (1962) Comparative cleansing efficiency of manual and power brushing. Journal of the American Dental Association 65, 26-29.
24. Rundegren, J., Hvid, E. B., Johansson, M. & Astrom, M. (1992a) Effect of 4 days of mouth rinsing with delmopinol and chlorhexidine on the vitality of plaque bacteria. Journal of Clinical Periodontology 19, 322-325.
25. Rundegren, J., Simonsson, T., Petersson, L. & Hansson, E. (1992b) Effect of delmopinol on the cohesion of glucan-containing plaque formed by Streptococcus mutans in a flow cell system. Journal of Dental Research 71, 1792-1796.
26. Schiott, C. R. (1972) Effect of chlorhexidine on the microflora of the oral cavity. Journal of Periodontal Research 8 (Suppl. 12), 7-10.
27. Simonsson, T., Arnebrant, T. & Peterson, L. (1991b) The effect of delmopinol on the salivary pellicles, the wettability of tooth surfaces in vivo and bacterial cell surfaces in vitro. Biofouling 3, 251-260.
28. Simonsson, T., Bondesson, H., Rundegren, J. & Edwardsson, S. (1991a) Effect of delmopinol on in vitro dental plaque formation, bacterial acid production and the number of microorganisms in human saliva. Oral Microbiology and Immunology 6, 305-309.
29. Turesky, S., Gilmore, N. D. & Glickman, I. (1970) Reduced plaque formation by the chloromethyl analogue of Victamine C. Journal of Periodontology 41, 41-43.