Carcinoembryonic antigen (CEA) mimicry by an anti-idiotypic scFv isolated from anti-Id 6.C4 hybridoma

Journal of Biotechnology

Volumn 127, Issue 4, 2007, Pages 615-625

  Pignatari, Graciela Conceição ^a   Takeshita, Daniela ^a   Parise, Carolina Bellini ^a   Soares, Fernando Augusto ^b   de Moraes, Jane Zveiter ^a   Han, Sang Won ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b A C CAMARGO CANCER CENTER   (Brazil)

Author keywords

Anti idiotype; CEA; DNA immunization; scFv

Indexed keywords

AMINO ACIDS; CARCINOGENS; DNA; IMMUNIZATION; IMMUNOLOGY; MONOCLONAL ANTIBODIES;

ANTI-IDIOTYPE; CARCINOEMBRYONIC ANTIGEN (CEA); DNA IMMUNIZATION;

ANTIGENS;

AMINO ACID; ANTIIDIOTYPIC ANTIBODY; CARCINOEMBRYONIC ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 6.C4; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; DNA IMMUNIZATION; FEMALE; HYBRIDOMA CELL CULTURE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOCARCINOMA; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODY SPECIFICITY; CARCINOEMBRYONIC ANTIGEN; COLONIC NEOPLASMS; FEMALE; HUMANS; HYBRIDOMAS; IMMUNIZATION; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED BALB C; MOLECULAR MIMICRY; VACCINES, DNA;

EID: 33845647564     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2006.08.007     Document Type: Article

References (31)

1. Alfonso M., Díaz A., Hernández A.M., Pérez A., Rodríguez E., Bitton R., Pérez R., and Vázquez A.M. An anti-idiotype vaccine elicits a specific response to N-glycolyl sialic acid residues of glycoconjugates in melanoma patients. J. Immunol. 168 (2002) 2523-2529
2. Bhattacharya-Chatterjee M., Mukerjee S., Biddle W., Fonn K.A., and Kohler H. Murine monoclonal antibody as a potential network antigen for human carcinoembryonic antigen. J. Immunol. 145 (1990) 2758-2765
3. Blumenthal R.D. Technology evaluation: Onyvax-105, Onyvax. Curr. Opin. Mol. Ther. 5 (2003) 668-672
4. Becker J.M., and Wilchek M. Inactivation by avidin of biotin-modified bacterophage. Biochim. Biophys. Acta 264 (1972) 165-170
5. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
6. Buchsbaum D.J., Hanna D.E., Randall B.C., Buchegger F., and Mach J.-P. Radiolabeling of monoclonal antibody against carcinoembryonic antigen with 88Y and biodistribution studies. Int. J. Nucl. Med. Biol. 12 (1985) 79-82
7. Carneiro C.R.W., Lopes J.D., and Brentani M.M. Carcinoembryonic antigen (CEA): production of immunoprecipitating monoclonal antibodies and development of an anzymeimmunoassay. Hybridoma 6 (1987) 689-692
8. Chatterjee M., Foon K., and Kohler H. Idiotypic antibody immunotherapy of cancer. Cancer Immunol. Immunother. 38 (1994) 75-82
9. Chong G., Bhatnagar A., Cunningham D., Cosgriff T.M., Harper P.G., Steward W., Bridgwater J., Moore M., Cassidy J., Coleman R., Coxon F., Redfern C.H., Jones J.J., Hawkins R., Northfelt D., Streedharan S., Valone F., and Carmichael J. Phase III trial of 5-fluorouracil and leucovorin plus either 3H1 anti-idiotype monoclonal antibody or placebo in patients with advanced colorectal cancer. Ann. Oncol. 17 (2006) 437-442
10. Coelho M., Gauthier P., Pugniere M., Roquet F., Pelegrin A., and Navarro-Teulon I. Isolation and characterization of a human anti-idiotypic scFv used as a surrogate tumour antigen to elicit an anti-HER-2/neu humoral response in mice. Br. J. Cancer 90 (2004) 2032-2041
11. Diaz A., Alfonso M., Alonso R., Saurez G., Troche M., Catalã M., Diaz R.M., Perez R., and Vazquez A.M. Immune responses in breast cancer patients immunized with an anti-idiotype antibody mimicking NeuGc-containing gangliosides. Clin. Immunol. 107 (2003) 80-89
12. Foon K.A., John W.J., Chakraborty M., Das R., Teitelbaum A., Garrison J., Kashala O., Chatterjee S.K., and Bhattacharya-Chatterjee M. Clinical and immune responses in resected colon cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen. J. Clin. Oncol. 17 (1999) 2889-2895
13. Francisco J.A., Gilliland L.K., Stebbins M.R., Norris N.A., Ledbetter J.A., and Siegall C.B. Activity of a single-chain immunotoxin that selectively kills lymphoma and other B-lineage cells expressing the CD40 antigen. Cancer Res. 55 (1995) 3099-3104
14. Gaida F.-J., Fenger U., Wergener C., and Neumaier M. A monoclonal anti-idiotypic antibody bearing the image of an epitope specific to the human carcinoembryonic antigen. Int. J. Cancer 51 (1992) 459-465
15. Han S.W., Moraes J.Z., Silva C.L., Chammas R., and Rodrigues M.M. DNA vaccines. In: Khudyakov Y.E., and Fields H.A. (Eds). Artificial DNA: Methods and Applications (2003), CRC Press, Boca Raton, FL 329-361
16. Huston J.S., Levinson D., Mudgett-Hunter M., Tai M.-S., Novotny J., Margolies M., Ridge R.J., Bruccoreli R.E., Haber E., Crea R., and Oppermann H. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in E. coli. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 5879-5883
17. Jou W.M., Verhoeyen M., Devos R., Saman E., Fang R., Huylebroeck D., and Fiers W. Complete structure of the hemagglutinin gene from the human influenza A/ victoria/3/75 (H3N2) strain as determined form cloned DNA. Cell 19 (1980) 683-696
18. Köhler G., and Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256 (1975) 495-497
19. Mach J.-P., Carrel S., Merenda C., Sordat B., and Cerottini J.-C. In vivo localization of radiolabelled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice. Nature 248 (1974) 704-706
20. Mittelman A., Chen Z.J., Yang H., Wong G.Y., and Ferrone S. Human high-molecular-weight-melanoma-associated-antigen (HMW_MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage-IV melanoma. Proc. Natl. Acad. Sci. (Wash.) 89 (1992) 466-470
21. Moraes J.Z., Carneiro C.R.W., Buchegger F., Mach J.-P., and Lopes J.D. Induction of an immune response through the idiotypic network with monoclonal anti-idiotype antibodies in the carcinoembryonic antigen system. J. Cell. Biochem. 50 (1992) 324-335
22. Moraes J.Z., Gesztesi J.-L., Westermann P., Le Doussal J.-M., Lopes J.D., and Mach J.-P. Anti-idiotypic monoclonal antibody AB3, reacting with the primary antigen (CEA), can localize in human colon-carcinoma xenografts as efficiently as AB1. Int. J. Cancer 57 (1994) 586-591
23. Park I.H., Youn J.H., Choi I.H., Nahm M.H., Kim S.J., and Shin J.S. Anti-idiotypic antibody as a potential candidate vaccine for Neisseria meningitides serogroup B. Infect. Immun. 73 (2004) 6399-6406 2005
24. Ramirez M.I., Boscardin S.B., Han S.W., Paranhos-Baccala G.S., Yoshida N., Kelly J.M., Mortara R.A., and Franco da Silveira J. Heterologous expression of a Trypanosoma cruzi surface glycoprotein (gp82) in mammalian cells indicates the existence of different signal sequence requirements and processing. J. Eukaryot. Microbiol. 46 (1999) 557-565
25. Reinartz S., Kohler S., Schlebusch H., Krista K., Giffels P., Renke K., Huober J., Mobus V., Kreienberg R., and Wagner U. Vaccination of patients with advanced ovarian carcinoma with the anti-idiotype. ACA125: Immunological response and survival (Phase Ib/II). Clin. Cancer Res. 10 (2004) 1580-1587
26. Sambrook J., Fritsch E.F., and Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. (1989), Cold Spring Harbor, NY
27. Schwegler C., Dorn-Beineke A., Nittka S., Stocking C., and Neumaier M. Monoclonal anti-idiotype antibody 6G6.C4 fused to GM-CSF is capable of breaking tolerance to carcinoembryonic antigen (CEA) in CEA-transgenic mice. Cancer Res. 65 (2005) 1925-1933
28. Thompson J., and Zimmermann W. The carcinoembryonic antigen gene family: structure, expression and evolution. Tumor Biol. 9 (1988) 63-83
29. Tripathi P.K., Qin H., Deng S., Xu C., Bhatacharya-Chatterjee M., Foon K.A., and Chartterjee S.K. Antigen mimicry by an anti-idiotypic antibody single chain variable fragment. Mol. Immunol. 35 (1998) 853-863
30. Tsumoto K., Nakaoki Y., Ueda Y., Ogasahara K., Yutani K., Watanabe K., and Kimagai I. Effect of the order of antibody variable regions on the expression of the single-chain Hyhel10 FV fragment in E. coli and the thermodynamic analysis of its antigen-binding properties. Biochem. Biophys. Res. Commun. 201 (1994) 546-551
31. Wagner U., Köhler S., Reinartz S., Giffels P., Houber J., Renke K., Schlebusch H., Biersack H.-J., Möbus V., Kreienberg R., bauknecht T., Krebs D., and Wallwiener D. Immunological consolidation of ovarian carcinoma recurrences with monoclonal anti-idiotype antibody ACA125: immune responses and survival in palliative treatment. Clin. Cancer Res. 7 (2001) 1154-1162