메뉴 건너뛰기




Volumn 54, Issue 6, 2006, Pages 291-302

Fundamental problems lie ahead in t́he drug discovery and commercialization process: Restructuring of the pharmaceutical industry and an improved partnership with academia are required

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CELECOXIB; ESOMEPRAZOLE; GABAPENTIN; LANSOPRAZOLE; OLANZAPINE; RECOMBINANT ERYTHROPOIETIN; SERTRALINE; SIMVASTATIN;

EID: 33845625628     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2006.05030     Document Type: Note
Times cited : (10)

References (25)
  • 1
    • 0033941034 scopus 로고    scopus 로고
    • Innovation in the pharmaceutical industry
    • Horrobin DF. Innovation in the pharmaceutical industry. J R Soc Med 2000;93:341-5.
    • (2000) J R Soc Med , vol.93 , pp. 341-345
    • Horrobin, D.F.1
  • 2
    • 1642354534 scopus 로고    scopus 로고
    • Surviving the blockbuster syndrome
    • Surviving the blockbuster syndrome. Science 2004;303:1796-99.
    • (2004) Science , vol.303 , pp. 1796-1799
  • 3
    • 0032872173 scopus 로고    scopus 로고
    • How many leads from Hts?
    • Lahana R. How many leads from Hts? Drug Discov Today 1999;4:447-8.
    • (1999) Drug Discov Today , vol.4 , pp. 447-448
    • Lahana, R.1
  • 4
    • 33845655054 scopus 로고    scopus 로고
    • Fewer drugs and biologics advancing from phase I trials to marketplace
    • Fewer drugs and biologics advancing from phase I trials to marketplace. J Invest Med 2004;52:434-5.
    • (2004) J Invest Med , vol.52 , pp. 434-435
  • 5
    • 0034678039 scopus 로고    scopus 로고
    • When pharma merges, R&D is the dowry
    • When pharma merges, R&D is the dowry. Science 2000;287:1952.
    • (2000) Science , vol.287 , pp. 1952
  • 6
    • 0033557197 scopus 로고    scopus 로고
    • Novel pharmacologic therapies for cystic fibrosis
    • Zeitlin PL. Novel pharmacologic therapies for cystic fibrosis. J Clin Invest 1999;103:447-52.
    • (1999) J Clin Invest , vol.103 , pp. 447-452
    • Zeitlin, P.L.1
  • 7
    • 84988497721 scopus 로고    scopus 로고
    • Available at: (accessed April 19, 2005)
    • About Nord. Available at: http://www.rarediseases.org/info/about.html (accessed April 19, 2005).
    • About Nord
  • 10
    • 0037337399 scopus 로고    scopus 로고
    • Treatment of Wilson disease with ammonium tetrathiomolybdate: III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy
    • Brewer GJ, Hedera P, Kluin KJ, et al. Treatment of Wilson disease with ammonium tetrathiomolybdate: III. initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy. Arch Neurol 2003;60:379-85.
    • (2003) Arch Neurol , vol.60 , pp. 379-385
    • Brewer, G.J.1    Hedera, P.2    Kluin, K.J.3
  • 11
    • 0037342259 scopus 로고    scopus 로고
    • Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice
    • Brewer GJ, Ullenbruch MR, Dick RB, et al. Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice. J Lab Clin Med 2003;141:210-6.
    • (2003) J Lab Clin Med , vol.141 , pp. 210-216
    • Brewer, G.J.1    Ullenbruch, M.R.2    Dick, R.B.3
  • 12
    • 8444244570 scopus 로고    scopus 로고
    • Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis
    • Brewer GJ, Dick R, Ullenbruch MR, et al. Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis. J Inorg Biochem 2004;98:2160-7.
    • (2004) J Inorg Biochem , vol.98 , pp. 2160-2167
    • Brewer, G.J.1    Dick, R.2    Ullenbruch, M.R.3
  • 13
    • 4444338573 scopus 로고    scopus 로고
    • Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice
    • Askari FK, Dick RB, Mao M, et al. Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice. Exp Biol Med 2004;229:857-63.
    • (2004) Exp Biol Med , vol.229 , pp. 857-863
    • Askari, F.K.1    Dick, R.B.2    Mao, M.3
  • 14
    • 4644266563 scopus 로고    scopus 로고
    • Tetrathiomolybdate protects against liver injury from acetaminophen in mice
    • Ma S, Hou G, Dick RD, et al. Tetrathiomolybdate protects against liver injury from acetaminophen in mice. J Appl Res Clin Exp Ther 2004;4:419-26.
    • (2004) J Appl Res Clin Exp Ther , vol.4 , pp. 419-426
    • Ma, S.1    Hou, G.2    Dick, R.D.3
  • 15
    • 26844452252 scopus 로고    scopus 로고
    • Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice
    • Hou G, Dick R, Abrams GD, et al. Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice. J Lab Clin Med 2006;146:299-303.
    • (2006) J Lab Clin Med , vol.146 , pp. 299-303
    • Hou, G.1    Dick, R.2    Abrams, G.D.3
  • 16
    • 0033950002 scopus 로고    scopus 로고
    • The physician-scientist: Career issues and challenges at the year 2000
    • Zemlo TR, Garrison HH, Partridge NC, et al. The physician-scientist: career issues and challenges at the year 2000. FASEB J 2000;14:221-30.
    • (2000) FASEB J , vol.14 , pp. 221-230
    • Zemlo, T.R.1    Garrison, H.H.2    Partridge, N.C.3
  • 17
    • 0038518203 scopus 로고    scopus 로고
    • Presidential address. Science as a way of life: Perplexities of a physician-scientist
    • Bloom FE. Presidential address. Science as a way of life: perplexities of a physician-scientist. Science 2003;300:1680-5.
    • (2003) Science , vol.300 , pp. 1680-1685
    • Bloom, F.E.1
  • 18
    • 0037433442 scopus 로고    scopus 로고
    • Central challenges facing the national clinical research enterprise
    • Sung NS, Crowley WF, Genel M, et al. Central challenges facing the national clinical research enterprise. JAMA 2003;289:1278-87.
    • (2003) JAMA , vol.289 , pp. 1278-1287
    • Sung, N.S.1    Crowley, W.F.2    Genel, M.3
  • 19
    • 0037433447 scopus 로고    scopus 로고
    • Translating biomedical research to the bedside: A national crisis and a call to action
    • Rosenberg RN. Translating biomedical research to the bedside: a national crisis and a call to action. JAMA 2003;289:1305-6.
    • (2003) JAMA , vol.289 , pp. 1305-1306
    • Rosenberg, R.N.1
  • 20
    • 33845641528 scopus 로고    scopus 로고
    • Clinical Research Enhancement Act passes Senate, moves on to House
    • Clinical Research Enhancement Act passes Senate, moves on to House. J Invest Med 2000;48:88-9.
    • (2000) J Invest Med , vol.48 , pp. 88-89
  • 22
    • 0035513528 scopus 로고    scopus 로고
    • Financial incentive for young clinical researchers: Loan repayment programs, public and private
    • Financial incentive for young clinical researchers: loan repayment programs, public and private. J Invest Med 2001;49:473-4.
    • (2001) J Invest Med , vol.49 , pp. 473-474
  • 23
    • 20144376965 scopus 로고    scopus 로고
    • Launching a new fellowship for medical students: The first years of the Doris Duke Clinical Research Fellowship Program
    • Gallin EK, Le Blancq SM. Launching a new fellowship for medical students: the first years of the Doris Duke Clinical Research Fellowship Program. J Invest Med 2005;53:73-81.
    • (2005) J Invest Med , vol.53 , pp. 73-81
    • Gallin, E.K.1    Le Blancq, S.M.2
  • 24
    • 0034983975 scopus 로고    scopus 로고
    • Crises in academic medicine
    • Brewer GJ. Crises in academic medicine. Exp Biol Med 2001;226:239-42.
    • (2001) Exp Biol Med , vol.226 , pp. 239-242
    • Brewer, G.J.1
  • 25
    • 33845644404 scopus 로고    scopus 로고
    • Millennium downsized
    • Marshall E, Couzin J. Millennium downsized. Science 2003;300:1637.
    • (2003) Science , vol.300 , pp. 1637
    • Marshall, E.1    Couzin, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.