Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1772, Issue 1, 2007, Pages 21-25

  Hautot, Dimitri ^a   Pankhurst, Quentin A ^b   Morris, Chris M ^c   Curtis, Andrew ^d   Burn, John ^d   Dobson, Jon ^a  

^a KEELE UNIVERSITY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d INSTITUTE OF HUMAN GENETICS   (United Kingdom)

Author keywords

Biomineralization; Iron; Magnetite; Nanoparticle; Neurodegenerative disease; Neuroferritinopathy; SQUID magnetometry; Verwey transition

Indexed keywords

FERRIC OXIDE; FERRITIN; MAGNETITE; NANOCRYSTAL; NANOPARTICLE; SUPERPARAMAGNETIC IRON OXIDE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BASAL GANGLION; BIOMINERALIZATION; BIOPHYSICAL EQUIPMENT; BODY TEMPERATURE; BRAIN TISSUE; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; GENE MUTATION; GENETIC DISORDER; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; ISOTHERMAL REMNANT MAGNETIZATION; MALE; MEASUREMENT; NEUROFERRITINOPATHY; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE MAGNETOMETRY; TEMPERATURE DEPENDENCE; TRANSMISSION ELECTRON MICROSCOPY; VERWEY TRANSITION;

AGED; BASAL GANGLIA; FEMALE; FERRIC COMPOUNDS; FERRITINS; FERROSOFERRIC OXIDE; HUMANS; MAGNETICS; NANOPARTICLES; NEURODEGENERATIVE DISEASES; RARE DISEASES; TEMPERATURE;

EID: 33845600918     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2006.09.011     Document Type: Article

References (36)

1. P.F. Chinnery, Gene Reviews (2005), available at (www.genetests.org) searching for 'neuroferritinopathy'.
2. Curtis A.R.J., Fey C., Morris C.M., Bindoff L.A., Ince P.G., Chinnery P.F., Coulthard A., Jackson M.J., Jackson A.P., McHale D.P., Hay D., Barker W.A., Markham A.F., Bates D., Curtis A., and Burn J. Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease. Nat. Genet. 28 (2001) 350-354
3. Chinnery P.F., Curtis A.R.J., Fey C., Coulthard A., Crompton D., Curtis A., Lombès A., and Burn J. Neuroferritinopathy in a French family with late onset dominant dystonia. J. Med. Genet. 40 (2003) e69
4. Zhao G., Bou-Abdallah F., Arosio P., Levi S., Janus-Chandler C., and Chasteen N.D. Multiple pathways for mineral core formation in mammalian apoferritin. The role of hydrogen peroxide. Biochemistry 42 (2003) 3142-3150
5. Schafer F.Q., Qian S.Y., and Buettner G.R. Iron and free radical oxidations in cell membranes. Cell. Mol. Biol. 46 (2000) 657-662
6. Kirschvink J.L., Kobayashi-Kirschvink A., and Woodford B.J. Magnetite biomineralization in the human brain. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 7683-7687
7. Goodman L. Alzheimer's disease-A clinicopathologic analysis of 23 cases with a theory on pathogenesis. J. Nerv. Ment. Dis. 118 (1953) 97-130
8. Kienzl E., Jellinger K., Stachelberger H., and Linert W. Iron as catalyst for oxidative stress in the pathogenesis of Parkinson's disease?. Life Sci. 65 18-19 (1999) 1973-1976
9. Bush A.I. Metals and neuroscience. Curr. Opin. Chem. Biol. 4 2 (2000) 184-191
10. Lynch T., Cherny R.A., and Bush A.I. Oxidative processes in Alzheimer's disease: the role of A beta-metal interactions. Exp. Gerontol. 35 4 (2000) 445-451
11. Ke Y., Xu R.S., Chi L.Y., Luo C., Gozal D., and Liu R.G. Oxidative stress is associated with intermittent hypoxia-mediated apoptosis in cortical neuronal cells. Free Radic. Biol. Med. 35 491 Suppl. 1 (2003) S158
12. Ke Y., and Qian Z.M. Iron misregulation in the brain: a primary cause of neurodegenerative disorders. Lancet Neurol. 2 4 (2003) 246-253
13. Hautot D., Pankhurst Q.A., Khan N., and Dobson J. Preliminary evaluation of nanoscale biogenic magnetite in Alzheimer's disease brain tissue. Proc. R. Soc. Lond., B 270 (2003) S62-S64
14. Collingwood J.F., Mikhaylova A., Davidson M., Batich C., Streit W.J., Terry J., and Dobson J. In situ characterization and mapping of iron compounds in Alzheimer's disease tissue. J. Alzheimer's Dis. 7 (2005) 267-272
15. Gossuin Y., Hautot D., Muller N., Pankhurst Q., Dobson J., Morris C., Gillis P., and Collingwood J. Looking for biogenic magnetite in brain ferritin using NMR relaxometry. NMR Biomed. 18 7 (2005) 469-472
16. Smith M.A., Harris P.L.R., Sayre L.M., and Perry G. Iron accumulation in Alzheimer's disease is a source of redox-generated free radicals. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 9866-9868
17. Sayre L.M., Perry G., Harris P.L.R., Liu Y.H., Schubert K.H., and Smith M.A. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. J. Neurochem. 74 (2000) 270-279
18. Quintana C., Lancin M., Marhic C., Pérez M., Martin-Benito J., Avila J., and Carrascosa J.L. Initial studies with high resolution TEM and electron energy loss spectroscopy studies of ferritin cores extracted from brains of patients with progressive supranuclear palsy and Alzheimer disease. Cell. Mol. Biol. 46 4 (2000) 807-820
19. Quintana C., Cowley J.M., and Marhic C. Electron nanodiffraction and high-resolution electron microscopy studies of the structure and composition of physiological and pathological ferritin. J. Struct. Biol. 147 (2004) 166-178
20. Hautot D., Pankhurst Q.A., and Dobson J. Superconducting quantum interference device measurements of dilute magnetic materials in biological samples. Rev. Sci. Instrum. 76 (2005) 45101-45104
21. Dobson J. Nanoscale biogenic iron oxides and neurodegenerative disease. FEBS Lett. 496 (2001) 1-5
22. Dobson J. Magnetic iron compounds in neurological disorders. Ann. N. Y. Acad. Sci. 1012 (2004) 183-192
23. Dobson J., and Grassi P. magnetic properties of human hippocampal tissue-Evaluation of artefact and contamination sources. Brain Res. Bull. 39 (1996) 255-259
24. Dubiel S.M., Zablotna-Rypien B., Mackey J.B., and Williams J.M. Magnetic properties of human liver and brain ferritin. Eur. Biophys. J. 28 (1999) 263-267
25. Makhlouf S.A., Parker F.T., and Berkowitz A.E. Magnetic hysteresis anomalies in ferritin. Phys. Rev. B 55 (1997) 717-720 (R14)
26. Gilles C., Bonville P., Wong K.K.W., and Mann S. Non-Langevin behaviour of the uncompensated magnetization in nanoparticles of artificial ferritin. Eur. Phys. J., B 17 (2000) 417-427
27. J. Collingwood, J. Dobson, Mapping and characterization of iron compounds in Alzheimer's tissue, J. Alzheimer's Dis. 10 (2--3) (in press).
28. Waltz F. The Verwey transition-A topical review. J. Phys., Condens. Matter 14 (2002) R285-R340
29. 3 nanoparticles' of M.P. Chem. Mater. 11 (1999) 3058-3064
30. 3.
31. Pankhurst Q.A., and Pollard R.J. Fine particle magnetic oxides. J. Phys. Condens. Matter 5 (1993) 8487-8508
32. L., Néel,Theorie des proprietes magnetiques des grains fins antiferromagnetiques: superparamagnetisme et superantiferromagnetisme. P. 412-440.
33. Cisowski S. Interacting vs. noninteracting single domain behaviour in natural and synthetic samples. Earth Planet. Sci. Lett. 26 (1982) 56-62
34. Gossuin Y., Muller R.N., and Gillis P. Relaxation induced by ferritin: a better understanding for an improved MRI iron quantification. NMR Biomed. 17 (2004) 427-432
35. Mikhailova A., Davidson M., Channel J.E.T., Guyodo Y., Batich C., and Dobson J. Detection, identification and mapping of iron anomalies in brain tissue using X-ray absorption spectroscopy. J. R. Soc. Interface 2 (2005) 33-37
36. Quintana C., Bellefqih S., Laval J.Y., Guerquin-Kern J.L., Wu T.D., Avila J., Ferrer I., Arranz R., and Patino C. Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J. Struct. Biol. 153 1 (2006) 42-54