Transactivation of EGFR mediates insulin-stimulated ERK1/2 activation and enhanced cell migration in human corneal epithelial cells

Molecular Vision

Volumn 12, Issue , 2006, Pages 1403-1410

  Lyu, Jungmook ^a   Lee, Kyung Suk ^a   Joo, Choun Ki ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ACTIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ILOMASTAT; INSULIN; MATRIGEL; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHALLOIDIN; RHODAMINE;

ARTICLE; BASEMENT MEMBRANE; CELL CULTURE; CELL IMMORTALIZATION; CELL MIGRATION; CONTROLLED STUDY; CORNEA CELL; CORNEA EPITHELIUM; CORNEA INJURY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCHEMISTRY; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; STRESS FIBER; TRANSACTIVATION; WOUND CLOSURE; WOUND HEALING; WOUND HEALING IMPAIRMENT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL LINE, TRANSFORMED; CELL MOVEMENT; CYTOSKELETON; DIPEPTIDES; ENZYME ACTIVATION; EPITHELIUM, CORNEAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INSULIN; ISOENZYMES; METALLOENDOPEPTIDASES; PHOSPHORYLATION; PROTEASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANS-ACTIVATION (GENETICS); TYRPHOSTINS; WOUND HEALING;

EID: 33845582895     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Wilson SE, He YG, Weng J, Zieske JD, Jester JV, Schultz GS, Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells. Exp Eye Res 1994; 59:665-78.
2. Nakamura M, Ofuji K, Chikama T, Nishida T. Combined effects of substance P and insulin-like growth factor-1 on corneal epithelial wound closure of rabbit in vivo. Curr Eye Res 1997; 16:275-8.
3. Zieske JD, Takahashi H, Hutcheon AE, Dalbone AC. Activation of epidermal growth factor receptor during corneal epithelial migration. Invest Ophthalmol Vis Sci 2000; 41:1346-55.
4. Lee CH, Whiteman AL, Murphy CJ, Barney NP, Taylor PB, Reid TW. Substance P, insulinlike growth factor 1, and surface healing. Arch Ophthalmol 2002; 120:215-7.
5. Weringer EJ, Kelso JM, Tamai IY, Arquilla ER. Effects of insulin on wound healing in diabetic mice. Acta Endocrinol (Copenh) 1982; 99:101-8.
6. Zagon IS, Sassani JW, McLaughlin PJ. Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats. Diabetes 2006; 55:1141-7.
7. Rocha EM, Cunha DA, Carneiro EM, Boschero AC, Saad MJ, Velloso LA. Identification of insulin in the tear film and insulin receptor and IGF-1 receptor on the human ocular surface. Invest Ophthalmol Vis Sci 2002; 43:963-7.
8. Shanley LJ, McCaig CD, Forrester JV, Zhao M. Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium. Invest Ophthalmol Vis Sci 2004; 45:1088-94.
9. Cheatham B, Kahn CR. Insulin action and the insulin signaling network. Endocr Rev 1995; 16:117-42.
10. Myers MG Jr, White MF. Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol 1996; 36:615-58.
11. Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296:1655-7.
12. Kahn BB. Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 1998; 92:593-6.
13. Xu KP, Ding Y, Ling J, Dong Z, Yu FS. Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells. Invest Ophthalmol Vis Sci 2004; 45:813-20.
14. Nakamura Y, Sotozono C, Kinoshita S. The epidermal growth factor receptor (EGFR): role in corneal wound healing and homeostasis. Exp Eye Res 2001; 72:511-7.
15. Fischer OM, Hart S, Gschwind A, Ullrich A. EGFR signal transactivation in cancer cells. Biochem Soc Trans 2003; 31:1203-8.
16. Roudabush FL, Pierce KL, Maudsley S, Khan KD, Luttrell LM. Transactivation of the EGF receptor mediates IGF-1 -stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. J Biol Chem 2000; 275:22583-9.
17. Block ER, Matela AR, SundarRaj N, Iszkula ER, Klarlund JK. Wounding induces motility in sheets of corneal epithelial cells through loss of spatial constraints: role of heparin-binding epidermal growth factor-like growth factor signaling. J Biol Chem 2004; 279:24307-12. Erratum in: J Biol Chem 2004; 279:36166.
18. Mitamura T, Higashiyama S, Taniguchi N, Klagsbrun M, Mekada E. Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. J Biol Chem 1995; 270:1015-9.
19. Ushio-Fukai M, Hilenski L, Santanam N, Becker PL, Ma Y, Griendling KK, Alexander RW, Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling. I Biol Chem 2001; 276:48269-75.
20. Kashiwagi A, Shinozaki K, Nishio Y, Maegawa H, Maeno Y, Kanazawa A, Kojima H, Haneda M, Hidaka H, Yasuda H, Kikkawa R. Endothelium-specific activation of NAD(P)H oxidase in aortas of exogenously hyperinsulinemic rats. Am J Physiol 1999; 277:E976-83.
21. Ceolotto G, Bevilacqua M, Papparella I, Baritono E, Franco L, Corvaja C, Mazzoni M, Semplicini A, Avogaro A. Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3′-kinase-dependent mechanism in human skin fibroblasts ex vivo. Diabetes 2004; 53:1344-51.
22. Bosco L, Venturini G, Willems D. In vitro lens transdifferentiation of Xenopus laevis outer cornea induced by Fibroblast Growth Factor (FGF). Development 1997; 124:421-8.
23. Rosenberg ME, Tervo TM, Immonen IJ, Muller LJ, Gronhagen-Riska C, Vesaluoma MH. Corneal structure and sensitivity in type 1 diabetes mellitus. Invest Ophthalmol Vis Sci 2000; 41:2915-21.
24. Martinez-deMena R, Obregon MJ. Insulin increases the adrenergic stimulation of 5′ deiodinase activity and mRNA expression in rat brown adipocytes; role of MAPK and PI3K. J Mol Endocrinol 2005; 34:139-51.
25. Lin YL, Chou CK. Phosphatidylinositol 3-kinase is required for the regulation of hepatitis B surface antigen production and mitogen-activated protein kinase activation by insulin but not by TPA. Biochem Biophys Res Commun 1998; 246:172-5.
26. Scassa ME, Guberman AS, Varone CL, Canepa ET. Phosphatidylinositol 3-kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene expression by insulin. Exp Cell Res 2001; 271:201-13.
27. Xu KP, Riggs A, Ding Y, Yu FS. Role of ErbB2 in Corneal Epithelial Wound Healing. Invest Ophthalmol Vis Sci 2004; 45:4277-83.
28. Chandrasekher G, Kakazu AH, Bazan HE. HGF- and KGF-induced activation of PI-3K/p7O s6 kinase pathway in corneal epithelial cells: its relevance in wound healing. Exp Eye Res 2001; 73:191-202.
29. Sharma GD, He J, Bazan HE. p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades. J Biol Chem 2003; 278:21989-97.
30. Wilson SE, He YG, Lloyd SA. EGF, EGF receptor, basic FGF, TGF beta-1, and IL-1 alpha mRNA in human corneal epithelial cells and stromal fibroblasts. Invest Ophthalmol Vis Sci 1992, 33:1756-65.
31. Zieske JD, Wasson M. Regional variation in distribution of EGF receptor in developing and adult corneal epithelium. J Cell Sci 1993; 106:145-52.
32. Harano T, Mizuno K. Phorbol ester-induced activation of a membrane-bound candidate pro-transforming growth factor-alpha processing enzyme. J Biol Chem 1994; 269:20305-11.
33. Frati L, Daniele S, Delogu A, Covelli I. Selective binding of the epidermal growth factor and its specific effects on the epithelial cells of the cornea. Exp Eye Res 1972; 14:135-41.
34. Watanabe K, Nakagawa S, Nishida T. Stimulatory effects of fibronectin and EGF on migration of corneal epithelial cells. Invest Ophthalmol Vis Sci 1987; 28:205-11.
35. Osada T, Watanabe S, Tanaka H, Hirose M, Miyazaki A, Sato N. Effect of mechanical strain on gastric cellular migration and proliferation during mucosal healing: role of Rho dependent and Rac dependent cytoskeletal reorganisation. Gut 1999; 45:508-15.
36. Nakamura M, Nagano T, Chikama T, Nishida T. Role of the small GTP-binding protein rho in epithelial cell migration in the rabbit cornea. Invest Ophthalmol Vis Sci 2001; 42:941-7.
37. Gao CY, Stepp MA, Fariss R, Zelenka P. Cdk5 regulates activation and localization of Src during corneal epithelial wound closure. J Cell Sci 2004; 117:4089-98.
38. Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995; 81:53-62.
39. Reif K, Nobes CD, Thomas G, Hall A, Cantrell DA. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr Biol 1996; 6:1445-55.