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Volumn 7, Issue 18, 2006, Pages 2481-2493

Kidney cancer therapy: New perspectives and avenues

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUORO 2 METHYL 5 INDOLYLOXY) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY]QUINAZOLINE; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; AXITINIB; BAY 490006; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; EGF 2001; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; GEFITINIB; IMATINIB; INTERFERON; INTERLEUKIN 2; LAPATINIB; MEGESTROL; PACLITAXEL; PANITUMUMAB; PAZOPANIB; PEGINTERFERON ALPHA2B; PLACEBO; SORAFENIB; SU 11246; SUNITINIB; TEMSIROLIMUS; THALIDOMIDE; UNINDEXED DRUG; VASCULOTROPIN INHIBITOR; VATALANIB; VINBLASTINE; XL 880;

EID: 33845578926     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.7.18.2481     Document Type: Review
Times cited : (16)

References (86)
  • 1
    • 0002688203 scopus 로고    scopus 로고
    • Cancer of the kidney and ureter
    • In: 6th edn. DeVita VT Jr, Hellman S, Rosenberg SA (Eds), Lippincott, Williams & Wilkins, Philadelphia, PA
    • LINEHAN WM, ZBAR B, BATES SE et al.: Cancer of the kidney and ureter. In: Cancer. Principles and Practice of Oncology, 6th edn. DeVita VT Jr, Hellman S, Rosenberg SA (Eds), Lippincott, Williams & Wilkins, Philadelphia, PA (2001):1362-1396.
    • (2001) Cancer. Principles and Practice of Oncology , pp. 1362-1396
    • Linehan, W.M.1    Zbar, B.2    Bates, S.E.3
  • 3
    • 24044437298 scopus 로고    scopus 로고
    • Clinical practice guidelines: Renal cell carcinoma
    • BUKOWSKI RM, NOVICK AC: Clinical practice guidelines: renal cell carcinoma. Cleve. Clin. J. Med. (1997) 64(1):1-44.
    • (1997) Cleve. Clin. J. Med. , vol.64 , Issue.1 , pp. 1-44
    • Bukowski, R.M.1    Novick, A.C.2
  • 4
    • 0027184296 scopus 로고
    • Treatment of metastatic renal cell carcinoma with recombinant interleukin-2 in combination with vinblastine or lymphokine-activated killer cells
    • KUEBLER JP, WHITEHEAD RP, WARD DL et al.: Treatment of metastatic renal cell carcinoma with recombinant interleukin-2 in combination with vinblastine or lymphokine-activated killer cells. J. Urol. (1993) 150(3):814-820.
    • (1993) J. Urol. , vol.150 , Issue.3 , pp. 814-820
    • Kuebler, J.P.1    Whitehead, R.P.2    Ward, D.L.3
  • 5
    • 0026625064 scopus 로고
    • Treatment of metastatic renal cell carcinoma by continuous intravenous infusion of recombinant interleukin-2: A single-center Phase II study
    • GEERTSEN PF, HERMANN GG, VON DER MAASE H et al.: Treatment of metastatic renal cell carcinoma by continuous intravenous infusion of recombinant interleukin-2: a single-center Phase II study. J. Clin. Oncol. (1992) 10(5):753-759.
    • (1992) J. Clin. Oncol. , vol.10 , Issue.5 , pp. 753-759
    • Geertsen, P.F.1    Hermann, G.G.2    Von Der Maase, H.3
  • 8
    • 33750510425 scopus 로고    scopus 로고
    • Pegylated interferon alpha-2B (PEG-Intron) for metastatic renal cell cancer (mRCC): Results of a Phase II clinical trial and biologic correlates of response
    • Abstr. 4528
    • KONDAGUNTA GV, BACIK J, ISHILL N et al.: Pegylated interferon alpha-2B (PEG-Intron) for metastatic renal cell cancer (mRCC): results of a Phase II clinical trial and biologic correlates of response. J. Clin. Oncol. (2006) 24(18S):Abstr. 4528.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Kondagunta, G.V.1    Bacik, J.2    Ishill, N.3
  • 9
    • 0026719617 scopus 로고
    • A Phase II trial of interleukin-2 and interferon alfa-2a in patients with advanced renal cell carcinoma
    • ILSON DH, MOTZER RJ, KRADIN RL et al.: A Phase II trial of interleukin-2 and interferon alfa-2a in patients with advanced renal cell carcinoma. J. Clin. Ontol. (1992) 10(7):1124-1130.
    • (1992) J. Clin. Ontol. , vol.10 , Issue.7 , pp. 1124-1130
    • Ilson, D.H.1    Motzer, R.J.2    Kradin, R.L.3
  • 10
    • 7144227930 scopus 로고    scopus 로고
    • Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma
    • Groupe. Francais d'Immunotherapie
    • NEGRIER S, ESCUDIER B, LASSET C et al.: Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie. N. Engl. J. Med. (1998) 338(18):1272-1278.
    • (1998) N. Engl. J. Med. , vol.338 , Issue.18 , pp. 1272-1278
    • Negrier, S.1    Escudier, B.2    Lasset, C.3
  • 11
    • 1442290393 scopus 로고    scopus 로고
    • Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma
    • MOTZER RJ, BACIK J, SCHWARTZ LH et al.: Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J. Clin. Oncol. (2004) 22(3):454-463.
    • (2004) J. Clin. Oncol. , vol.22 , Issue.3 , pp. 454-463
    • Motzer, R.J.1    Bacik, J.2    Schwartz, L.H.3
  • 12
    • 18844386435 scopus 로고    scopus 로고
    • Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy
    • UPTON MP, PARKER RA, YOUMANS A et al.: Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy. J. Immunother. (2005) 28(5):488-495.
    • (2005) J. Immunother. , vol.28 , Issue.5 , pp. 488-495
    • Upton, M.P.1    Parker, R.A.2    Youmans, A.3
  • 13
    • 12344335787 scopus 로고    scopus 로고
    • Renal cell carcinoma: Review of novel single-agent therapeutics and combination regimens
    • AMATO RJ: Renal cell carcinoma: review of novel single-agent therapeutics and combination regimens. Ann. Oncol. (2005) 16(1):7-15.
    • (2005) Ann. Oncol. , vol.16 , Issue.1 , pp. 7-15
    • Amato, R.J.1
  • 14
    • 33644840580 scopus 로고    scopus 로고
    • Targeted therapy for metastatic renal cell carcinoma
    • PATEL PH, CHAGANTI RS, MOTZER RJ: Targeted therapy for metastatic renal cell carcinoma. Br. J. Cancer (2006) 94(5):614-619.
    • (2006) Br. J. Cancer , vol.94 , Issue.5 , pp. 614-619
    • Patel, P.H.1    Chaganti, R.S.2    Motzer, R.J.3
  • 15
    • 30944452354 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib
    • HAINSWORTH JD, SOSMAN JA, SPIGEL DR et al.: Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib. J. Clin. Oncol. (2005) 23(31):7889-7896.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.31 , pp. 7889-7896
    • Hainsworth, J.D.1    Sosman, J.A.2    Spigel, D.R.3
  • 16
    • 0027954044 scopus 로고
    • Mutations of the VHL tumour suppressor gene in renal carcinoma
    • GNARRA JR, TORY K, WENG Y et al.: Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat. Genet. (1994) 7(1):85-90.
    • (1994) Nat. Genet. , vol.7 , Issue.1 , pp. 85-90
    • Gnarra, J.R.1    Tory, K.2    Weng, Y.3
  • 17
    • 0027240519 scopus 로고
    • Identification of the von Hippel-Lindau disease tumor suppressor gene
    • LATIF F, TORY K, GNARRA J et al.: Identification of the von Hippel-Lindau disease tumor suppressor gene. Science (1993) 260:1317-1320.
    • (1993) Science , vol.260 , pp. 1317-1320
    • Latif, F.1    Tory, K.2    Gnarra, J.3
  • 18
    • 0029785321 scopus 로고    scopus 로고
    • Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
    • ILIOPOULOS O, LEVY AP, JIANG C et al.: Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl. Acad. Sci. USA (1996) 93(20):10595-10599.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , Issue.20 , pp. 10595-10599
    • Iliopoulos, O.1    Levy, A.P.2    Jiang, C.3
  • 19
    • 0033135109 scopus 로고    scopus 로고
    • Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma
    • ANANTH S, KNEBELMANN B, GRUNING W et al.: Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma. Cancer Res. (1999) 59(9):22l0-2216.
    • (1999) Cancer Res. , vol.59 , Issue.9
    • Ananth, S.1    Knebelmann, B.2    Gruning, W.3
  • 20
    • 15344340324 scopus 로고    scopus 로고
    • Bevacizumab: Antiangiogenic cancer therapy
    • CULY C: Bevacizumab: antiangiogenic cancer therapy. Drugs Today (2005) 41(1):23-36.
    • (2005) Drugs Today , vol.41 , Issue.1 , pp. 23-36
    • Culy, C.1
  • 21
    • 27944456879 scopus 로고    scopus 로고
    • Investigating the potential of bevacizumab in other indications: Metastatic renal cell, non-small cell lung, pancreatic and breast cancer
    • DR GRAMONT A, VAN CUTSEM E: Investigating the potential of bevacizumab in other indications: metastatic renal cell, non-small cell lung, pancreatic and breast cancer. Oncology (2005) 69(3):46-56.
    • (2005) Oncology , vol.69 , Issue.3 , pp. 46-56
    • Dr Gramont, A.1    Van Cutsem, E.2
  • 22
    • 4644229716 scopus 로고    scopus 로고
    • Bevacizumab for patients with metastatic renal cancer: An update
    • YANG JC: Bevacizumab for patients with metastatic renal cancer: an update. Clin. Cancer Res. (2004) 10:6367-6370.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6367-6370
    • Yang, J.C.1
  • 23
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • YANG JC, HAWORTH L, SHERRY RM et al.: A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N. Engl. J. Med. (2003) 349(5):427-434.
    • (2003) N. Engl. J. Med. , vol.349 , Issue.5 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 24
    • 0036651519 scopus 로고    scopus 로고
    • EGFR antisense treatment of human HNSCC cell lines down-regulates VEGF expression and endothelial cell migration
    • RIEDEL F, GOTTE K, LI M et al.: EGFR antisense treatment of human HNSCC cell lines down-regulates VEGF expression and endothelial cell migration. Int. J. Oncol. (2002) 21(1):11-16.
    • (2002) Int. J. Oncol. , vol.21 , Issue.1 , pp. 11-16
    • Riedel, F.1    Gotte, K.2    Li, M.3
  • 25
    • 33748077429 scopus 로고    scopus 로고
    • Epidermal growth factor receptor/angiogenesis dual targeting: Preclinical experience
    • BOZEC A, FISCHEL JL, MILANO G: Epidermal growth factor receptor/ angiogenesis dual targeting: preclinical experience. Curr. Opin. Oncol. (2006) 18(4):330-334.
    • (2006) Curr. Opin. Oncol. , vol.18 , Issue.4 , pp. 330-334
    • Bozec, A.1    Fischel, J.L.2    Milano, G.3
  • 26
    • 33750938968 scopus 로고    scopus 로고
    • Bevacizumab with or without erlotinib in metastatic renal cell carcinoma (RCC)
    • Abstr. 4523
    • BUKOWSKI RM, KABBINAVAR F, FIGLIN RA et al.: Bevacizumab with or without erlotinib in metastatic renal cell carcinoma (RCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 4523.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Bukowski, R.M.1    Kabbinavar, F.2    Figlin, R.A.3
  • 27
    • 27944477164 scopus 로고    scopus 로고
    • Bevacizumab, erlotinib, and imatinib in the treatment of patients (pts) with advanced renal cell carcinoma (RCC): A Minnie Pearl Cancer Research Network Phase I/II trial
    • Abstr. 4542
    • HAINSWORTH JD, SOSMAN JA, SPIGEL DR et al.: Bevacizumab, erlotinib, and imatinib in the treatment of patients (pts) with advanced renal cell carcinoma (RCC): a Minnie Pearl Cancer Research Network Phase I/II trial. J. Clin. Oncol. (2005) 23(16S):Abstr. 4542.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 S
    • Hainsworth, J.D.1    Sosman, J.A.2    Spigel, D.R.3
  • 28
    • 33845567496 scopus 로고    scopus 로고
    • Bevacizumab, erlotinib, and imatinib in the treatment of patients with advanced renal cell carcinoma: Update of a multicenter Phase II trial
    • Abstr. 4594
    • THOMPSON DS, GRECO FA, SPIGEL DR et al.: Bevacizumab, erlotinib, and imatinib in the treatment of patients with advanced renal cell carcinoma: update of a multicenter Phase II trial. J. Clin. Oncol. (2006) 24(18S):Abstr. 4594.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Thompson, D.S.1    Greco, F.A.2    Spigel, D.R.3
  • 29
    • 1942470411 scopus 로고    scopus 로고
    • Cancer and Leukemia Group B 90206: A randomized Phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma
    • RINI BI, HALABI S, TAYLOR J et al.: Cancer and Leukemia Group B 90206: a randomized Phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma. Clin. Cancer Res. (2004) 10(8):2584-2586.
    • (2004) Clin. Cancer Res. , vol.10 , Issue.8 , pp. 2584-2586
    • Rini, B.I.1    Halabi, S.2    Taylor, J.3
  • 30
    • 33845587513 scopus 로고    scopus 로고
    • Phase-II trial of thalidomide for patients with metastatic renal cell carcinoma (RCC)
    • Abstr. 4761
    • GREEN D, MEZA-JUNCO J, ARCE C et al.: Phase-II trial of thalidomide for patients with metastatic renal cell carcinoma (RCC). J. Clin. Oncol. (2005) 23(16S):Abstr. 4761.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 S
    • Green, D.1    Meza-Junco, J.2    Arce, C.3
  • 31
    • 33845573526 scopus 로고    scopus 로고
    • A multicenter Phase II study of thalidomide in combination with interleukin-2 (IL-2) in patients with previously untreated metastatic renal cell carcinonsa (MRCC)
    • Abstr. 14636
    • FARRAY D, CLARK JI, KUZEL T, DUTCHER JP: A multicenter Phase II study of thalidomide in combination with interleukin-2 (IL-2) in patients with previously untreated metastatic renal cell carcinonsa (MRCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 14636.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Farray, D.1    Clark, J.I.2    Kuzel, T.3    Dutcher, J.P.4
  • 32
    • 33747862130 scopus 로고    scopus 로고
    • Phase II trial of pegylated Interferon alpha-2b, GM-CSF, and Thalidomide in metastatic progressive renal cell carcinoma
    • Abstr. 4800
    • SAWHNEY R, BRESCIA F, KEANE T, CLARKE H, CHAUDHARY UB: Phase II trial of pegylated Interferon alpha-2b, GM-CSF, and Thalidomide in metastatic progressive renal cell carcinoma. J. Clin. Oncol. (2005) 23(16S):Abstr. 4800.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 S
    • Sawhney, R.1    Brescia, F.2    Keane, T.3    Clarke, H.4    Chaudhary, U.B.5
  • 33
    • 33845579078 scopus 로고    scopus 로고
    • Phase II study of lenalidomide in patients (pts) with metastatic renal cell cancer (MRCC)
    • Abstr. 4533
    • MARSH L, KHAN M, NEEDLE M, AMATO R: Phase II study of lenalidomide in patients (pts) with metastatic renal cell cancer (MRCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 4533.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Marsh, L.1    Khan, M.2    Needle, M.3    Amato, R.4
  • 34
    • 33845592130 scopus 로고    scopus 로고
    • Phase II study of lenalidomide in patients (pts.) with metastatic renal cell carcinoma (MRCC)
    • Abstr. 4539
    • CHOUEIRI TK, DREICER R, RINI BI et al.: Phase II study of lenalidomide in patients (pts.) with metastatic renal cell carcinoma (MRCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 4539.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Choueiri, T.K.1    Dreicer, R.2    Rini, B.I.3
  • 35
    • 33845351712 scopus 로고    scopus 로고
    • Phase II study of volociximab (M200), an α5β1 anti-integrin antibody in refractory metastatic clear cell renal cell cancer (RCC)
    • Abstr. 4535
    • FIGLIN RA, KONDAGUNTA GV, YAZJI S, MOTZER RJ, BUKOWSKI RM: Phase II study of volociximab (M200), an α5β1 anti-integrin antibody in refractory metastatic clear cell renal cell cancer (RCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 4535.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Figlin, R.A.1    Kondagunta, G.V.2    Yazji, S.3    Motzer, R.J.4    Bukowski, R.M.5
  • 36
    • 25144465192 scopus 로고    scopus 로고
    • Targeting the vascular endothelial growth factor pathway in renal cell carcinoma: A tissue array based analysis
    • Abstr. 4536
    • LEPPERT JT, LAM JS, YU H et al.: Targeting the vascular endothelial growth factor pathway in renal cell carcinoma: a tissue array based analysis. J. Clin. Oncol. (2005) 23(16S):Abstr. 4536.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 S
    • Leppert, J.T.1    Lam, J.S.2    Yu, H.3
  • 37
    • 0037307858 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein: New insights into oxygen sensing and cancer
    • KIM W, KAELLN WG JR: The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Curr. Opin. Genet. Dev. (2003) 13(1):55-60.
    • (2003) Curr. Opin. Genet. Dev. , vol.13 , Issue.1 , pp. 55-60
    • Kim, W.1    Kaelln Jr., W.G.2
  • 39
    • 33644962673 scopus 로고    scopus 로고
    • Sorafenib: Scientific rationales for single-agent and combination therapy in clear-cell renal cell carcinoma
    • GOLLOB JA: Sorafenib: scientific rationales for single-agent and combination therapy in clear-cell renal cell carcinoma. Clin. Genitourin Cancer. (2005) 4(3):167-174.
    • (2005) Clin. Genitourin Cancer. , vol.4 , Issue.3 , pp. 167-174
    • Gollob, J.A.1
  • 40
    • 20444485232 scopus 로고    scopus 로고
    • Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/-renal cancer
    • SMITH K, GUNARATNAM L, MORLEY M et al.: Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/-renal cancer. Cancer Res. (2005) 65(12):5221-5230.
    • (2005) Cancer Res. , vol.65 , Issue.12 , pp. 5221-5230
    • Smith, K.1    Gunaratnam, L.2    Morley, M.3
  • 41
    • 0032407024 scopus 로고    scopus 로고
    • Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice
    • PREWETT M, ROTHMAN M, WAKSAL H et al.: Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice. Clin. Cancer Res. (1998) 4(12):2957-2966.
    • (1998) Clin. Cancer Res. , vol.4 , Issue.12 , pp. 2957-2966
    • Prewett, M.1    Rothman, M.2    Waksal, H.3
  • 42
    • 9744240281 scopus 로고    scopus 로고
    • A Phase II trial of gefitinib (Iressa, ZD1839) in stage IV and recurrent renal cell carcinoma
    • DAWSON NA, GUO C, ZAK R et al.: A Phase II trial of gefitinib (Iressa, ZD1839) in stage IV and recurrent renal cell carcinoma. Clin. Cancer Res. (2004) 10(23):7812-7819.
    • (2004) Clin. Cancer Res. , vol.10 , Issue.23 , pp. 7812-7819
    • Dawson, N.A.1    Guo, C.2    Zak, R.3
  • 43
    • 12444251187 scopus 로고    scopus 로고
    • Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma
    • MOTZER RJ, AMATO R, TODD M et al.: Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma. Invest. New Drugs (2003) 21(1):99-101.
    • (2003) Invest. New Drugs , vol.21 , Issue.1 , pp. 99-101
    • Motzer, R.J.1    Amato, R.2    Todd, M.3
  • 44
    • 21344437413 scopus 로고    scopus 로고
    • Bevacizumab and erlotinib in the treatment of patients with metastatic renal carcinoma (RCC): Update of a Phase II multicenter trial
    • Abstr. 4540
    • SPIGEL DR, HAINSWORTH JD, SOSMAN JA et al.: Bevacizumab and erlotinib in the treatment of patients with metastatic renal carcinoma (RCC): update of a Phase II multicenter trial. J. Clin. Oncol. (2005) 23(16S):Abstr. 4540.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 S
    • Spigel, D.R.1    Hainsworth, J.D.2    Sosman, J.A.3
  • 45
    • 33750938968 scopus 로고    scopus 로고
    • Bevacizumab with or without erlotinib in metastatic renal cell carcinoma (RCC)
    • Abstr. 4523
    • BUKOWSKI RM, KABBINAVAR F, FIGLIN RA et al.: Bevacizumab with or without erlotinib in metastatic renal cell carcinoma (RCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 4523.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Bukowski, R.M.1    Kabbinavar, F.2    Figlin, R.A.3
  • 46
    • 22044438985 scopus 로고    scopus 로고
    • Synergistic growth inhibition by Iressa and rapamycin is modulated by vhl mutations in renal cell carcinoma
    • GEMMILL RM, ZHOU M, COSTA L et al.: Synergistic growth inhibition by Iressa and rapamycin is modulated by vhl mutations in renal cell carcinoma. Br. J. Cancer. (2005) 92(12):2266-2277.
    • (2005) Br. J. Cancer. , vol.92 , Issue.12 , pp. 2266-2277
    • Gemmill, R.M.1    Zhou, M.2    Costa, L.3
  • 47
    • 27244457769 scopus 로고    scopus 로고
    • Raf: A strategic target for therapeutic development against cancer
    • BEERAM M, PATNAIK A, ROWINSKY EK: Raf: a strategic target for therapeutic development against cancer. J. Clin. Oncol. (2005) 23(27):6771-6790.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.27 , pp. 6771-6790
    • Beeram, M.1    Patnaik, A.2    Rowinsky, E.K.3
  • 48
    • 0037032835 scopus 로고    scopus 로고
    • The protein kinase complement of the human genome
    • MANNING G, WHYTE DB, MARTINEZ R et al.: The protein kinase complement of the human genome. Science (2002) 298:1912-1934.
    • (2002) Science , vol.298 , pp. 1912-1934
    • Manning, G.1    Whyte, D.B.2    Martinez, R.3
  • 49
    • 23044510046 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors
    • CLARK JW, EDER JP, RYAN D et al.: Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors. Clin. Cancer Res. (2005) 11(15):5472-5480.
    • (2005) Clin. Cancer Res. , vol.11 , Issue.15 , pp. 5472-5480
    • Clark, J.W.1    Eder, J.P.2    Ryan, D.3
  • 50
    • 4644259265 scopus 로고    scopus 로고
    • Kinase inhibition with BAY 43-9006 in renal cell carcinoma
    • AHMAD T, EISEN T: Kinase inhibition with BAY 43-9006 in renal cell carcinoma. Clin. Cancer Res. (2004) 10:6388-6392.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6388-6392
    • Ahmad, T.1    Eisen, T.2
  • 51
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • WILHELM SM, CARTER C, TANG L et al.: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. (2004) 64(19):7099-7109.
    • (2004) Cancer Res. , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 52
    • 20044382799 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
    • STRUMBERG D, RICHLY H, HILGER RA et al.: Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J. Clin. Oncol. (2005) 23(5):965-972.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.5 , pp. 965-972
    • Strumberg, D.1    Richly, H.2    Hilger, R.A.3
  • 53
    • 0036401105 scopus 로고    scopus 로고
    • BAY 43-9006: Preclinical data
    • WILHELM S, CHIEN DS: BAY 43-9006: preclinical data. Curr. Pharm. Des. (2002) 8(25):2255-2257.
    • (2002) Curr. Pharm. Des. , vol.8 , Issue.25 , pp. 2255-2257
    • Wilhelm, S.1    Chien, D.S.2
  • 54
    • 33845583622 scopus 로고    scopus 로고
    • Anti-proliferative effects of sorafenib in clear cell renal cell carcinoma (CCRCC) cell lines: Relationship to von Hippel Lindau protein (pVHL) expression and hypoxia
    • Abstr. 4601
    • AL HAZZOURI A, VAZIRI SA, LYNCH M et al.: Anti-proliferative effects of sorafenib in clear cell renal cell carcinoma (CCRCC) cell lines: relationship to von Hippel Lindau protein (pVHL) expression and hypoxia. J. Clin. Oncol. (2006) 24(18S):Abstr. 4601.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Al Hazzouri, A.1    Vaziri, S.A.2    Lynch, M.3
  • 55
    • 0037468875 scopus 로고    scopus 로고
    • Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dim ethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
    • SUN L, LIANG C, SHIRAZIAN S et al.: Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dim ethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J. Med. Chem. (2003) 46(7):1116-1119.
    • (2003) J. Med. Chem. , vol.46 , Issue.7 , pp. 1116-1119
    • Sun, L.1    Liang, C.2    Shirazian, S.3
  • 56
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • MENDEL DB, LAIRD AD, XIN X et al.: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. (2003) 9(1):327-337.
    • (2003) Clin. Cancer Res. , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 57
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • FAIVRE S, DELBALDO C, VERA K et al.: Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J. Clin. Oncol. (2006) 24(1):25-35.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.1 , pp. 25-35
    • Faivre, S.1    Delbaldo, C.2    Vera, K.3
  • 58
    • 33646865114 scopus 로고    scopus 로고
    • Randomized Phase III trial of the multi-kinase inhibitor sorafenib (BAY-9006) in patients with advanced renal cell carcinoma (RCC)
    • Abstr. 794
    • ESCUDIER B, SZCZYLIK C, EISEN T et al.: Randomized Phase III trial of the multi-kinase inhibitor sorafenib (BAY-9006) in patients with advanced renal cell carcinoma (RCC) Eur. J. Cancer Suppl. (2005) 3(2):226 Abstr. 794.
    • (2005) Eur. J. Cancer Suppl. , vol.3 , Issue.2 , pp. 226
    • Escudier, B.1    Szczylik, C.2    Eisen, T.3
  • 59
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • RATAIN MJ, EISEN T, STADLER WM et al.: Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. (2006) 24(16):2505-2512.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.16 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 60
    • 33748614966 scopus 로고    scopus 로고
    • Randomized Phase III trial of sorafenib in advanced renal cell carcinoma (RCC): Impact of crossover on survival
    • For The Sorafenib TARGETs Clinical Trial Group. Abstr. 4524
    • EISEN T, BUKOWSKI RM, STAEHLER M et al.: For The Sorafenib TARGETs Clinical Trial Group. Randomized Phase III trial of sorafenib in advanced renal cell carcinoma (RCC): Impact of crossover on survival. J. Clin. Oncol. (2006) 24(18S):Abstr. 4524.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Eisen, T.1    Bukowski, R.M.2    Staehler, M.3
  • 61
    • 33845594648 scopus 로고    scopus 로고
    • A comparison of quality of life and symptoms in kidney cancer patients receiving sorafenib versus placebo
    • Abstr. 4534
    • DHANDA R, GONDEK K, SONG J, CELLA D, BUKOWSKI RM, ESCUDIER B: A comparison of quality of life and symptoms in kidney cancer patients receiving sorafenib versus placebo. J. Clin. Oncol. (2006) 24(18S):Abstr. 4534.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Dhanda, R.1    Gondek, K.2    Song, J.3    Cella, D.4    Bukowski, R.M.5    Escudier, B.6
  • 62
    • 33746501603 scopus 로고    scopus 로고
    • Randomized Phase II trial of the multi-kinase inhibitor sorafenib versus interferon (IFN) in treatment-naïve patients with metastatic renal cell carcinoma (mRCC)
    • Abstr. 4501
    • ESCUDIER B, SZCZYLIK C, DEMKOW T et al.: Randomized Phase II trial of the multi-kinase inhibitor sorafenib versus interferon (IFN) in treatment-naïve patients with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. (2006) 24(185):Abstr. 4501.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Escudier, B.1    Szczylik, C.2    Demkow, T.3
  • 63
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • MOTZER RJ, MICHAELSON MD, REDMAN BC et al.: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J. Clin. Oncol. (2006) 24(1):16-24.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.1 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.C.3
  • 64
    • 33646462684 scopus 로고    scopus 로고
    • Sunitinib malate (SU11248) shows antitumour activity in patients with metastatic renal cell carcinoma: Updated results from Phase II trials
    • Abstr. 797
    • MOTZER RJ, RINI B, MICHAELSON MD et al.: Sunitinib malate (SU11248) shows antitumour activity in patients with metastatic renal cell carcinoma: updated results from Phase II trials. Eur. J. Cancer Suppl. (2005) 3(2):227 Abstr. 797.
    • (2005) Eur. J. Cancer Suppl. , vol.3 , Issue.2 , pp. 227
    • Motzer, R.J.1    Rini, B.2    Michaelson, M.D.3
  • 65
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • MOTZER RJ, RINI BI, BUKOWSKI RM et al.: Sunitinib in patients with metastatic renal cell carcinoma. JAMA (2006) 295(21):2516-2524.
    • (2006) JAMA , vol.295 , Issue.21 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 66
    • 33748590610 scopus 로고    scopus 로고
    • Phase III randomized trial of sunitinib malate (SU11248) versus interferon-alfa (IFN-α) as first-line systemic therapy for patients with metastatic renal cell carcinoma (mRCC)
    • Abstr. LBA3
    • MOTZER RJ, HUTSON TE, TOMCZAK P et al.: Phase III randomized trial of sunitinib malate (SU11248) versus interferon-alfa (IFN-α) as first-line systemic therapy for patients with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. (2006) 24(18S):Abstr. LBA3.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 67
    • 33845571367 scopus 로고    scopus 로고
    • Antitumor effects of sorafenib and sunitinib in patients (pts) with metastatic renal cell carcinoma (mRCC) who had prior therapy with anti-angiogenic agents
    • Abstr. 4597
    • TAMASKAR I, SHAHEEN P, WOOD L et al.: Antitumor effects of sorafenib and sunitinib in patients (pts) with metastatic renal cell carcinoma (mRCC) who had prior therapy with anti-angiogenic agents. J. Clin. Oncol. (2006) 24(18S):Abstr. 4597.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Tamaskar, I.1    Shaheen, P.2    Wood, L.3
  • 68
    • 33750616807 scopus 로고    scopus 로고
    • A Phase II study of sunitinib administered in a continuous daily regimen in patients with cytokine-refractory metastatic renal cell carcinoma (mRCC)
    • Abstr. 4529
    • DE MULDER PH, ROIGAS J, GILLESSEN S et al.: A Phase II study of sunitinib administered in a continuous daily regimen in patients with cytokine-refractory metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 4529.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • De Mulder, P.H.1    Roigas, J.2    Gillessen, S.3
  • 69
    • 33845576732 scopus 로고    scopus 로고
    • A Phase I study of sunitinib malate (SU11248) in combination with gefitinib in patients with metastatic renal cell carcinoma (mRCC)
    • Abstr. 4537
    • RONNEN EA, KONDAGUNTA GV, LAU C et al.: A Phase I study of sunitinib malate (SU11248) in combination with gefitinib in patients with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 4537.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Ronnen, E.A.1    Kondagunta, G.V.2    Lau, C.3
  • 70
    • 33845330140 scopus 로고    scopus 로고
    • T regulatory cells (Treg) in patients with metastatic renal cell carcinoma (mRCC) decrease during sunitinib treatment: Correlations with clinical responses and T helper 1/T helper 2(Th1/Th2) bias
    • Abstr. 2526
    • SUPPIAH R, FINKE J, RINI BI et al.: T regulatory cells (Treg) in patients with metastatic renal cell carcinoma (mRCC) decrease during sunitinib treatment: Correlations with clinical responses and T helper 1/ T helper 2(Th1/Th2) bias. J. Clin. Oncol. (2006) 24(18S):Abstr. 2526.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Suppiah, R.1    Finke, J.2    Rini, B.I.3
  • 71
    • 33845583842 scopus 로고    scopus 로고
    • Multitargeted therapy in kidney cancer
    • In:. Physician's Education Resourse Publication
    • BUKOWSKI RM, FIGLIN RA: Multitargeted therapy in kidney cancer. In: Oncology Consultations. Physician's Education Resourse Publication. (2006) 3(4):1-10.
    • (2006) Oncology Consultations , vol.3 , Issue.4 , pp. 1-10
    • Bukowski, R.M.1    Figlin, R.A.2
  • 72
    • 23844446510 scopus 로고    scopus 로고
    • AG-013736, a multi-target tyrosine kinase receptor inhibitor, demonstrates anti-tumor activity in a Phase II study of cytokine-refractory, metastatic renal-cell cancer (RCC)
    • Abstr. 4509
    • RINI B, RIXE O, BUKOWSKI R et al.: AG-013736, a multi-target tyrosine kinase receptor inhibitor, demonstrates anti-tumor activity in a Phase II study of cytokine-refractory, metastatic renal-cell cancer (RCC). J. Clin. Oncol. (2005) 23(Suppl.):380s Abstr. 4509.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.SUPPL.
    • Rini, B.1    Rixe, O.2    Bukowski, R.3
  • 73
    • 33644935244 scopus 로고    scopus 로고
    • SU11248 and AG013736: Current data and future trials in renal cell carcinoma
    • RINI BI: SU11248 and AG013736: current data and future trials in renal cell carcinoma. Clin. Genitourin. Cancer (2005) 4(3):175-180.
    • (2005) Clin. Genitourin. Cancer , vol.4 , Issue.3 , pp. 175-180
    • Rini, B.I.1
  • 74
    • 33644618100 scopus 로고    scopus 로고
    • Targeting angiogenesis with vascular endothelial growth factor receptor small-molecule inhibitors: Novel agents with potential in lung cancer
    • WAKELEE HA, SCHILLER JH: Targeting angiogenesis with vascular endothelial growth factor receptor small-molecule inhibitors: novel agents with potential in lung cancer. Clin. Lung Cancer (2005) 7(Suppl. 1):S31-S38.
    • (2005) Clin. Lung Cancer , vol.7 , Issue.SUPPL. 1
    • Wakelee, H.A.1    Schiller, J.H.2
  • 75
    • 33646867027 scopus 로고    scopus 로고
    • A Phase II study of GW786034 using a randomized discontinuation design in patients with locally recurrent or metastatic clear-cell renal cell carcinoma
    • HUTSON TE, BUKOWSKI RM: A Phase II study of GW786034 using a randomized discontinuation design in patients with locally recurrent or metastatic clear-cell renal cell carcinoma. Clin. Genitourin. Cancer (2006) 4(4):296-298.
    • (2006) Clin. Genitourin. Cancer , vol.4 , Issue.4 , pp. 296-298
    • Hutson, T.E.1    Bukowski, R.M.2
  • 76
    • 31544436073 scopus 로고    scopus 로고
    • A physiologic imaging pilot study of breast cancer treated with AZD2171
    • MILLER KD, MILLER M, MEHROTRA S et al.: A physiologic imaging pilot study of breast cancer treated with AZD2171. Clin. Cancer Res. (2006) 12(1):281-288.
    • (2006) Clin. Cancer Res. , vol.12 , Issue.1 , pp. 281-288
    • Miller, K.D.1    Miller, M.2    Mehrotra, S.3
  • 77
    • 33751288182 scopus 로고    scopus 로고
    • Tykerb. Renal Cell Cancer Study Group and GSK CoreT. Efficacy of lapatinib in patients with high tumor EGFR expression: Results of a Phase III trial in advanced renal cell carcinoma (RCC)
    • Abstr. 4502
    • RAVAUD A, GARDNER J, HAWKINS R et al.: Tykerb. Renal Cell Cancer Study Group and GSK CoreT. Efficacy of lapatinib in patients with high tumor EGFR expression: results of a Phase III trial in advanced renal cell carcinoma (RCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 4502.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Ravaud, A.1    Gardner, J.2    Hawkins, R.3
  • 78
    • 33845573525 scopus 로고    scopus 로고
    • A Phase I study of a novel spectrum selective kinase inhibitor (SSKI), XL880, administered orally in patients (pts) with advanced solid tumors (STs)
    • Abstr. 3041
    • EDER JP, APPLEMAN L, HEATH E et al.: A Phase I study of a novel spectrum selective kinase inhibitor (SSKI), XL880, administered orally in patients (pts) with advanced solid tumors (STs). J. Clin. Oncol. (2006) 24(18S):Abstr. 3041.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Eder, J.P.1    Appleman, L.2    Heath, E.3
  • 79
    • 33845594278 scopus 로고    scopus 로고
    • Sorafenib plus interferon-α2b (IFN) as first-line therapy for advanced renal cell carcinoma (RCC): SWOG 0412
    • Abstr. 4525
    • RYAN CW, GOLDMAN BH, LARA PN et al.: Sorafenib plus interferon-α2b (IFN) as first-line therapy for advanced renal cell carcinoma (RCC): SWOG 0412. J. Clin. Oncol. (2006) 24(18S):Abstr. 4525.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Ryan, C.W.1    Goldman, B.H.2    Lara, P.N.3
  • 80
    • 33748883788 scopus 로고    scopus 로고
    • Phase II trial of sorafenib plus interferon-alpha 2b (IFN-α2b) as first- or second-line therapy in patients (pts) with metastatic renal cell cancer (RCC)
    • Abstr. 4538
    • GOLLOB J, RICHMOND T, JONES J et al.: Phase II trial of sorafenib plus interferon-alpha 2b (IFN-α2b) as first- or second-line therapy in patients (pts) with metastatic renal cell cancer (RCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 4538.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Gollob, J.1    Richmond, T.2    Jones, J.3
  • 81
    • 33845590501 scopus 로고    scopus 로고
    • A Phase II study of imatinib mesylate (IM) and interferon-alpha (IFNA) in metastatic renal cell carcinoma (RCC)
    • Abstr. 4689
    • POLITE BN, DESAI AA, PETERSON AC, MANCHEN B, STADLER WM: A Phase II study of imatinib mesylate (IM) and interferon-alpha (IFNA) in metastatic renal cell carcinoma (RCC). J. Clin. Oncol. (2005) 23:16S Abstr. 4689.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 S
    • Polite, B.N.1    Desai, A.A.2    Peterson, A.C.3    Manchen, B.4    Stadler, W.M.5
  • 82
    • 33845592129 scopus 로고    scopus 로고
    • Interferon-alpha (IFN) and gefitinib or imatinib in patients (pts) with metastatic renal cell carcinoma (RCC)
    • Abstr. 14616
    • JAC J, ZHAI Q, KAREIDY M, HERNANDEZ J, MARSH L, AMATO R: Interferon-alpha (IFN) and gefitinib or imatinib in patients (pts) with metastatic renal cell carcinoma (RCC). J. Clin. Oncol. (2006) 24(18S):Abstr. 14616.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Jac, J.1    Zhai, Q.2    Kareidy, M.3    Hernandez, J.4    Marsh, L.5    Amato, R.6
  • 83
    • 33845585780 scopus 로고    scopus 로고
    • Characterization of the mTOR pathway in renal cell carcinoma and its use in predicting patient selection for agents targeting this pathway
    • Abstr. 4539
    • FIGLIN RA, SELIGSON D, WU H et al.: Characterization of the mTOR pathway in renal cell carcinoma and its use in predicting patient selection for agents targeting this pathway. J. Clin. Oncol. (2005) 23(16S):Abstr. 4539.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 S
    • Figlin, R.A.1    Seligson, D.2    Wu, H.3
  • 84
    • 33745242315 scopus 로고    scopus 로고
    • Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus
    • DEL BUFALO D, CIUFFREDA L, TRISCIUOGLIO D et al.: Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus. Cancer Res. (2006) 66(11):5549-5554.
    • (2006) Cancer Res. , vol.66 , Issue.11 , pp. 5549-5554
    • Del Bufalo, D.1    Ciuffreda, L.2    Trisciuoglio, D.3
  • 85
    • 33748363166 scopus 로고    scopus 로고
    • A Phase III, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC)
    • Abstr. LBA4
    • HUDES G, CARDUCCI M, TOMCZAK P et al.: A Phase III, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC). J. Clin. Oncol. (2006) 24(18S):Abstr. LBA4.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 S
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 86
    • 33750241252 scopus 로고    scopus 로고
    • Summary of results in patients with nsetastatic renal cell cancer (RCC) from Phase I studies of RAD001 (everolimus)
    • Abstr. 14599
    • PORTER LI., BURRIS HA, JONES SF et al.: Summary of results in patients with nsetastatic renal cell cancer (RCC) from Phase I studies of RAD001 (everolimus). J. Clin. Oncol. (2006) 24(18S):Abstr. 14599.
    • (2006) J. Clin. Oncol. , vol.4 , Issue.18 S
    • Porter, L.I.1    Burris, H.A.2    Jones, S.F.3


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