Optimizing antigen cocktails for detection of Mycobacterium bovis in herds with different prevalences of bovine tuberculosis: ESAT6-CFP10 mixture shows optimal sensitivity and specificity

Journal of Clinical Microbiology

Volumn 44, Issue 12, 2006, Pages 4326-4335

  Aagaard, C ^a   Govaerts, M ^b,f   Meikle, V ^c   Vallecillo, A J ^d   Gutierrez Pabello, J A ^d   Suarez Guemes F ^d   McNair, J ^e   Cataldi, A ^c   Espitia, C ^d   Andersen, P ^a   Pollock, J M ^e  

^a STATENS SERUM INSTITUT   (Denmark)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA INTA   (Argentina)

^d UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^e AGRI FOOD AND BIOSCIENCES INSTITUTE   (United Kingdom)

^f VETERINARY AND AGROCHEMICAL RESEARCH CENTRE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CULTURE FILTRATE PROTEIN 10; EARLY SECRETORY ANTIGENIC TARGET 6; PROTEIN MBP70; PROTEIN PE13; PROTEIN PE5; PROTEIN TB10.4; PROTEIN TB27.4;

ANIMAL TISSUE; ARGENTINA; ARTICLE; BACTERIUM DETECTION; CATTLE DISEASE; CONTROLLED STUDY; DISEASE MARKER; MEXICO; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SKIN TEST; UNITED KINGDOM;

ANIMALS; ANTIGENS, BACTERIAL; ARGENTINA; BACTERIOLOGICAL TECHNIQUES; CATTLE; HYPERSENSITIVITY, DELAYED; INTERFERON TYPE II; MEXICO; MYCOBACTERIUM BOVIS; NORTHERN IRELAND; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; SKIN TESTS; TUBERCULOSIS, BOVINE;

ANIMALIA; BOS TAURUS; MYCOBACTERIUM BOVIS;

EID: 33845571195     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.01184-06     Document Type: Article

References (37)

1. Aagaard, C., M. Govaerts, L. Meng Okkels, P. Andersen, and J. M. Pollock. 2003. Genomic approach to identification of Mycobacterium bovis diagnostic antigens in cattle. J. Clin. Microbiol. 41:3719-3728.
2. Abernethy, D. A., G. O. Denny, F. D. Menzies, P. McGuckian, N. Honhold, and A. R. Roberts. 2006. The Northern Ireland programme for the control and eradication of Mycobacterium bovis. Vet. Microbiol. 112:231-237.
3. Amadori, M., S. Tagliabue, S. Lauzi, G. Finazzi, G. Lombardi, P. Telo, L. Pacciarini, and L. Bonizzi. 2002. Diagnosis of Mycobacterium bovis infection in calves sensitized by mycobacteria of the avium/intracellulare group. J. Vet. Med. B Infect. Dis. Vet. Public Health 49:89-96.
4. Andersen, P., A. B. Andersen, A. L. Sorensen, and S. Nagai. 1995. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J. Immunol. 154:3359-3372.
5. Behr, M. A., M. A. Wilson, W. P. Gill, H. Salamon, G. K. Schoolnik, S. Rane, and P. M. Small. 1999. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 284:1520-1523.
6. Berthet, F. X., P. B. Rasmussen, I. Rosenkrands, P. Andersen, and B. Gicquel. 1998. A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10). Microbiology 144(Pt 11):3195-3203.
7. Buddle, B. M., N. A. Parlane, D. L. Keen, F. E. Aldwell, J. M. Pollock, K. Lightbody, and P. Andersen. 1999. Differentiation between Mycobacterium bovis BCG-vaccinated and M. bovis-infected cattle by using recombinant mycobacterial antigens. Clin. Diagn. Lab. Immunol. 6:1-5.
8. Buddle, B. M., B. J. Wards, F. E. Aldwell, D. M. Collins, and G. W. de Lisle. 2002. Influence of sensitisation to environmental mycobacteria on subsequent vaccination against bovine tuberculosis. Vaccine 20:1126-1133.
9. Buddle, B. M., D. N. Wedlock, N. A. Parlane, L. A. Corner, G. W. De Lisle, and M. A. Skinner. 2003. Revaccination of neonatal calves with Mycobacterium bovis BCG reduces the level of protection against bovine tuberculosis induced by a single vaccination. Infect. Immun. 71:6411-6419.
10. Cockle, P. J., S. V. Gordon, A. Lalvani, B. M. Buddle, R. G. Hewinson, and H. M. Vordermeier. 2002. Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics. Infect. Immun. 70:6996-7003.
11. Cole, S. T., R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, S. V. Gordon, K. Eiglmeier, S. Gas, C. E. Barry III, F. Tekaia, K. Badcock, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. Davies, K. Devlin, T. Feltwell, S. Gentles, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, A. Krogh, J. McLean, S. Moule, L. Murphy, K. Oliver, J. Osborne, M. A. Quail, M. A. Rajandream, J. Rogers, S. Rutter, K. Seeger, J. Skelton, R. Squares, S. Squares, J. E. Sulston, K. Taylor, S. Whitehead, and B. G. Barrell. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544.
12. Cosivi, O., J. M. Grange, C. J. Daborn, M. C. Raviglione, T. Fujikura, D. Cousins, R. A. Robinson, H. F. Huchzermeyer, I. de Kantor, and F. X. Meslin. 1998. Zoonotic tuberculosis due to Mycobacterium bovis in developing countries. Emerg. Infect. Dis. 4:59-70.
13. de Kantor, I. N., and V. Ritacco. 2006. An update on bovine tuberculosis programmes in Latin American and Caribbean countries. Vet. Microbiol. 112:111-118.
14. Delogu, G., and M. J. Brennan. 2001. Comparative immune response to PE and PE-PGRS antigens of Mycobacterium tuberculosis. Infect. Immun. 69:5606-5611.
15. Doherty, T. M., A. Demissie, J. Olobo, D. Wolday, S. Britton, T. Eguale, P. Ravn, and P. Andersen. 2002. Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. J. Clin. Microbiol. 40:704-706.
16. Garnier, T., K. Eiglmeier, J. C. Camus, N. Medina, H. Mansoor, M. Pryor, S. Duthoy, S. Grondin, C. Lacroix, C. Monsempe, S. Simon, B. Harris, R. Atkin, J. Doggett, R. Mayes, L. Keating, P. R. Wheeler, J. Parkhill, B. G. Barrell, S. T. Cole, S. V. Gordon, and R. G. Hewinson. 2003. The complete genome sequence of Mycobacterium bovis. Proc. Natl. Acad. Sci. USA 100:7877-7882.
17. Gilbert, M., A. Mitchell, D. Bourn, J. Mawdsley, R. Clifton-Hadley, and W. Wint. 2005. Cattle movements and bovine tuberculosis in Great Britain. Nature 435:491-496.
18. Gordon, S. V., R. Brosch, A. Billault, T. Garnier, K. Eiglmeier, and S. T. Cole. 1999. Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays. Mol. Microbiol. 32:643-655.
19. Harboe, M., T. Oettinger, H. G. Wiker, I. Rosenkrands, and P. Andersen. 1996. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect. Immun. 64:16-22.
20. Hardie, R. M., and J. M. Watson. 1992. Mycobacterium bovis in England and Wales: past, present and future. Epidemiol. Infect. 109:23-33.
21. Hermans, P. W., D. van Soolingen, J. W. Dale, A. R. Schuitema, et al. 1990. Insertion element IS9S6 from Mycobacterium tuberculosis: a useful tool for diagnosis and epidemiology of tuberculosis. J. Clin. Microbiol. 28:2051-2058.
22. Hewinson, R. G., S. L. Michell, W. P. Russell, R. A. McAdam, and W. R. Jacobs, Jr. 1996. Molecular characterization of MPT83: a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70. Scand. J. Immunol. 43:490-499.
23. Lalvani, A., P. Nagvenkar, Z. Udwadia, A. A. Pathan, K. A. Wilkinson, J. S. Shastri, K. Ewer, A. V. Hill, A. Mehta, and C. Rodrigues. 2001. Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians. J. Infect. Dis. 183:469-477.
24. Lalvani, A., A. A. Pathan, H. McShane, R. J. Wilkinson, M. Latif, C. P. Conlon, G. Pasvol, and A. V. Hill. 2001. Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Am. J. Respir. Crit. Care Med. 163:824-828.
25. Lightbody, K. A., R. M. Girvin, D. P. Mackie, S. D. Neill, and J. M. Pollock. 1998. T-cell recognition of mycobacterial proteins MPB70 and MPB64 in cattle immunized with antigen and infected with Mycobacterium bovis. Scand. J. Immunol. 48:44-51.
26. Mustafa, A. S., F. Oftung, H. A. Amoudy, N. M. Madi, A. T. Abal, F. Shaban, I. Rosen Krands, and P. Andersen. 2000. Multiple epitopes from the Mycobacterium tuberculosis ESAT-6 antigen are recognized by antigen-specific human T cell lines. Clin. Infect. Dis. 30(Suppl. 3):S201-S205.
27. Pollock, J. M., and P. Andersen. 1997. The potential of the ESAT-6 antigen secreted by virulent mycobacteria for specific diagnosis of tuberculosis. J. Infect. Dis. 175:1251-1254.
28. Pollock, J. M., R. M. Girvin, K. A. Lightbody, R. A. Clements, S. D. Neill, B. M. Buddle, and P. Andersen. 2000. Assessment of defined antigens for the diagnosis of bovine tuberculosis in skin test-reactor cattle. Vet. Rec. 146:659-665.
29. Pollock, J. M., and S. D. Neill. 2002. Mycobacterium bovis infection and tuberculosis in cattle. Vet. J. 163:115-127.
30. Ravn, P., A. Demissie, T. Eguale, H. Wondwosson, D. Lein, H. A. Amoudy, A. S. Mustafa, A. K. Jensen, A. Holm, I. Rosenkrands, F. Oftung, J. Olobo, F. von Reyn, and P. Andersen. 1999. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J. Infect. Dis. 179:637-645.
31. Renshaw, P. S., K. L. Lightbody, V. Veverka, F. W. Muskett, G. Kelly, T. A. Frenkiel, S. V. Gordon, R. G. Hewinson, B. Burke, J. Norman, R. A. Williamson, and M. D. Carr. 2005. Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6. EMBO J. 24:2491-2498.
32. van Pinxteren, L. A., P. Ravn, E. M. Agger, J. Pollock, and P. Andersen. 2000. Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10. Clin. Diagn. Lab. Immunol. 7:155-160.
33. Vordermeier, H. M., P. C. Cockle, A. Whelan, S. Rhodes, N. Palmer, D. Bakker, and R. G. Hewinson. 1999. Development of diagnostic reagents to differentiate between Mycobacterium bovis BCG vaccination and M. bovis infection in cattle. Clin. Diagn. Lab. Immunol. 6:675-682.
34. Vordermeier, H. M., A. Whelan, P. J. Cockle, L. Farrant, N. Palmer, and R. G. Hewinson. 2001. Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle. Clin. Diagn. Lab. Immunol. 8:571-578.
35. Wood, P. R., L. A. Corner, J. S. Rothel, J. L. Ripper, T. Fifis, B. S. McCormick, B. Francis, L. Melville, K. Small, K. de Witte, et al. 1992. A field evaluation of serological and cellular diagnostic tests for bovine tuberculosis. Vet. Microbiol. 31:71-79.
36. Wood, P. R., and J. S. Rothel. 1994. In vitro immunodiagnostic assays for bovine tuberculosis. Vet. Microbiol. 40:125-135.
37. World Organization for Animal Health. 2004. Annual animal disease status, bovine tuberculosis. World Organization for Animal Health, Paris, France.