Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia?

Leukemia and Lymphoma

Volumn 47, Issue 12, 2006, Pages 2431-2432

  Pui, Ching Hon ^a   Relling, Mary V ^a   Evans, William E ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; FOLINIC ACID; METHOTREXATE;

ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER CONTROL; CANCER REGRESSION; CANCER RELAPSE; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; COGNITION; DISEASE FREE SURVIVAL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DOSE COMPARISON; DRUG MEGADOSE; FOLLOW UP; GENOTYPE; HIGH RISK PATIENT; HUMAN; INTELLIGENCE QUOTIENT; LEUKEMIA CELL; LYMPHOBLAST; META ANALYSIS; NOTE; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; SKULL IRRADIATION; SYSTEMATIC REVIEW;

CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHILD; CLINICAL TRIALS; HUMANS; LEUCOVORIN; LEUKEMIA, LYMPHOCYTIC, ACUTE; METHOTREXATE; PILOT PROJECTS; RANDOMIZED CONTROLLED TRIALS; RECURRENCE; RISK;

EID: 33845562827     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190600955837     Document Type: Note

References (9)

1. Niemeyer, C and Gelber, R and Tarbell, N and Donnelly, M and Clavell, L and Blattner, S and (1991) Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (Protocol 81-01 update) Blood, 78, pp. 2514-2519.
2. Clarke, M and Gaynon, P and Hann, I and Harrison, G and Masera, G and Peto, R and (2003) CNS-directed therapy for childhood acute lymphoblastic leukemia: Childhood ALL Collaborative Group overview of 43 randomized trials J Clin Oncol, 21, pp. 1798-1809.
3. Pui, C and Evans, W. (2006) Treatment of acute lymphoblastic leukemia N Engl J Med, 354, pp. 166-178.
4. Pui, C and Sandlund, J and Pei, D and Campana, D and Rivera, G and Ribeiro, R and (2004) Improved outcome for children with acute lymphoblastic leukemia: Results of Total Therapy Study XIIIB at St Jude Children's Research Hospital Blood, 104, pp. 2690-2696.
5. Schrappe, M and Reiter, A and Ludwig, W and Harbott, J and Zimmermann, M and Hiddemann, W and (2000) Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: Results of trial ALL-BFM 90 Blood, 95, pp. 3310-3322.
6. Evans, W and Schell, M and Pui, C. (1990) MTX Clearance is more important for intermediate-risk ALL J Clin Oncol, 8, pp. 1115-1119.
7. Pui, C and Relling, M and Evans, W. (2003) Role of pharmacogenomics and pharmacodynamics in the treatment of acute lymphoblastic leukemia Best Prac Res Clin Haematol, 15, pp. 741-756.
8. Pui, C and Relling, M and Downing, J. (2004) Acute lymphoblastic leukemia N Engl J Med, 350, pp. 1535-1548.
9. Kager, L and Check, M and Yang, W and Zaza, G and Cheng, Q and Panetta, J and (2005) Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics J Clin Invest, 115, pp. 110-117.