Reflexly evoked coactivation of cardiac vagal and sympathetic motor outflows: Observations and functional implications

Clinical and Experimental Pharmacology and Physiology

Volumn 33, Issue 12, 2006, Pages 1245-1250

  Paton, Julian F R ^a   Nalivaiko, Eugene ^c   Boscan, Pedro ^d,e   Pickering, Anthony E ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

^c FLINDERS UNIVERSITY   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e USA   (United States)

Author keywords

Arrhythmia; Baroreceptor reflex; Cardiac vagus; Diving response; Nociception

Indexed keywords

ATENOLOL; ATROPINE; DOFETILIDE; METHYLSCOPOLAMINE; NEUROPEPTIDE; NORADRENALIN; PROPRANOLOL; VASOACTIVE INTESTINAL POLYPEPTIDE;

AUTONOMIC INNERVATION; BRADYCARDIA; CHEMORECEPTOR; CONFERENCE PAPER; DOSE RESPONSE; DRUG MECHANISM; EVOKED RESPONSE; HEART ARRHYTHMIA; HEART INNERVATION; HEART MUSCLE POTENTIAL; HEART VENTRICLE TACHYCARDIA; HUMAN; NOCICEPTIVE RECEPTOR; NONHUMAN; OCULOCARDIAC REFLEX; PRESSORECEPTOR REFLEX; REFLEX; SYMPATHETIC TONE; TACHYCARDIA; VAGUS NERVE STIMULATION;

ANIMALS; ARRHYTHMIA; BRADYCARDIA; HEART; HUMANS; MOTOR NEURONS; SYMPATHETIC NERVOUS SYSTEM; TACHYCARDIA; VAGUS NERVE;

EID: 33845543298     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2006.04518.x     Document Type: Conference Paper

References (54)

1. Kollai K, Koizumi K. Reciprocal and non-reciprocal action of the vagal and sympathetic nerves innervating the heart. J. Auton. Nerv. Syst. 1979; 1: 33-52.
2. Andersen HT. Physiological adaptations in diving vertebrates. Physiol. Rev. 1966; 46: 212-43.
3. Angell-James JE, de Burgh Daly M. Nasal reflexes. Proc. R. Soc. Med. 1969; 62: 1287-93.
4. de Burgh Daly M. Peripheral arterial chemoreceptors and respiratory-cardiovascular integration. In: Monographs of the Physiological Society. Oxford Medical Publications, Clarendon Press, Oxford. 1996; 476-91.
5. Dutschmann M, Herbert H. Fos expression in the rat parabrachial and Kolliker-Fuse nuclei after electrical stimulation of the trigeminal ethmoidal nerve and water stimulation of the nasal mucosa. Exp. Brain Res. 1997; 117: 97-110.
6. Dutschmann M, Paton JFR. Is the diving reflex present in the working heart-brainstem preparation (WHBP) of the rat? J. Physiol. 2000; 523P: P254-5.
7. Gandevia SC, McCloskey DI Potter EK. Reflex bradycardia occurring in response to diving, nasopharyngeal stimulation and ocular pressure, and its modification by respiration and swallowing. J. Physiol. 1978; 276: 383-94.
8. Grassi G, Seravalle G, Giannattasio C, Saino A, Turri C, Mancia G. Baroreflex and non-baroreflex modulation of vagal cardiac control after myocardial infarction. Am. J. Cardiol. 1999; 84: 525-9.
9. Heath ME, Downey JA. The cold face test (diving reflex) in clinical autonomic assessment: Methodological considerations and repeatability of responses. Clin. Sci. 1990; 78: 139-47.
10. Katz RL, Bigger JT. Cardiac arrhythmias during anesthesia and operation. Anesthesiol. 1970; 33: 193-213.
11. Kayikcioglu O, Kayikcioglu M, Erakgun T, Guler C. Electrocardiographic changes during subconjunctival injections. Int. Ophthalmol. 1999; 23: 37-41.
12. Kirsch RE, Samet P, Kugel V, Axelrod S. Electrocardiographic changes during ocular surgery and their prevention by retrobulbar injection. Arch. Ophthalmol. 1957; 58: 348-56.
13. Martner J, Wandenvik H, Lisander B. Apnoea and bradycardia from submersion in 'chronically' decerebrated cats. Acta Physiol. Scand. 1977; 101: 476-80.
14. McCulloch PF, Panneton WM. Fos immunohistochemical determination of brainstem neuronal activation in the muskrat after nasal stimulation. Neuroscience 1997; 78: 913-25.
15. Nalivaiko E, De Pasquale CG, Blessing WW. Electrocardiographic changes associated with the nasopharyngeal reflex in conscious rabbits: Vago-sympathetic co-activation. Auton. Neurosci. 2003; 105: 101-4.
16. Rigel DF. Effects of neuropeptides on heart rate in dogs: Comparison of VIP, PHI, NPY, CGRP, and NT. Am. J. Physiol. 1988; 255: H311-17.
17. White SW, McRitchie RJ, Franklin DL. Autonomic and cardiovascular effects of nasal inhalation of cigarette smoke in the rabbit. Aust. J Exp. Biol. Med. Sci. 1974; 52: 111-26.
18. Koizumi K, Kollai M. Control of reciprocal and non-reciprocal action of vagal and sympathetic efferents: Study of centrally induced reactions. J. Auton. Nerv. Syst. 1981; 3: 483-501.
19. Koizumi K, Terui N, Kollai M, Brooks CM. Functional significance of coactivation of vagal and sympathetic cardiac nerves. Proc. Natl Acad. Sci. USA 1982; 79: 2116-20.
20. Nalivaiko E, De Pasquale CG, Blessing WW. Ventricular arrhythmias triggered by alerting stimuli in conscious rabbits pre-treated with dofetilide. Basic Res. Cardiol. 2004; 99: 142-51.
21. Abram SE, Kostreva DR, Hopp FA, Kampine JP. Cardiovascular responses to noxious radiant heat in anesthetized cats. Am. J. Physiol. 1983; 245: R576-80.
22. Adams DB, Baccelli G, Mancia G, Zanchetti A. Cardiovascular changes during naturally elicited fighting behavior in the cat. Am. J. Physiol. 1969; 216: 1226-35.
23. al'Absi M, Buchanan TW, Marrero A, Lovallo WR. Sex differences in pain perception and cardiovascular responses in persons with parental history for hypertension. Pain 1999; 83: 331-8.
24. Bang OU, Lund A. Inhibition of glutamate antagonists, MK-801 and NBQX, of cutaneo-cardiovascular pain reflex in rats. Eur. J. Pharmacol. 1991; 203: 133-5.
25. Barr GA. Maturation of the biphasic behavioral and heart rate response in the formalin test. Pharmacol. Biochem. Behav. 1998; 60: 329-35.
26. Boscan P, Paton JFR. The role of the solitary tract nucleus in mediating nociceptive evoked cardiorespiratory responses. Auton. Neurosci. 2001; 86: 170-82.
27. Martin J, Sutherland CJ, Zbrozyna AW. Habituation and conditioning of the defense reactions and their cardiovascular components in cats and dogs. Pflügers Arch. 1976; 365: 37-47.
28. Panneton WM, McCulloch PF, Sun W. Trigemino-autonomic connections in the muskrat: The neural substrate for the diving response. Brain Res. 2000; 874: 48-65.
29. Prud'homme MJ, Houdeau E, Serghini R, Tillet Y, Schemann M, Rousseau JP. Small intensely fluorescent cells of the rat paracervical ganglion synthesize adrenaline, receive afferent innervation from postganglionic cholinergic neurones, and contain muscarinic receptors. Brain Res. 1999; 821: 141-9.
30. Schwartz PJ. The autonomic nervous system and life-threatening arrhythmias. In: Vatner SF (ed.). Nervous Control of the Heart. Harwood Academic Publishers, Amsterdam. 1996; 329-56.
31. Paton JFR, Boscan P, Pickering AE, Nalivaiko E. The yin and yang of cardiac autonomic control: Vago-sympathetic interactions revisited. Brain Res. Rev. 2005; 49: 555-65.
32. Levy MN. Vagal tachycardias. In. Levy MN, Schwartz PJ (eds). Vagal Control of the Heart: Experimental Basis and Clinical Implications. Futura Publishing, London. 1994; 305-15.
33. Levy MN, Martin P, Iano T, Zieske H. Paradoxical effect of vagus nerve stimulation on heart rate in dogs. Circ. Res. 1969; 25: 303-14.
34. Smith JC, Stephens DP, Winchester PK, Williamson JW. Facial cooling-induced bradycardia: Attenuating effect of central command at exercise onset. Med. Sci. Sports Exerc. 1997; 29: 320-5.
35. Vassalle M, Mandel WJ, Holder MS. Catecholamine stores under vagal control. Am. J. Physiol. 1970; 218: 115-23.
36. Oberlander TF, Grunau RE, Pitfield S, Whitfield, MF, Saul JP. The developmental character of cardiac autonomic responses to an acute noxious event in 4- and 8-month-old healthy infants. Pediatr. Res. 1999; 45: 519-25.
37. Ackerman MJ, Tester DJ, Porter CJ. Swimming, a gene-specific arrhythmogenic trigger for inherited long QT syndrome. Mayo Clin. Proc. 1999; 74: 1088-94.
38. Blanc VF, Hardy JF, Milot J, Jacob JL. The oculocardiac reflex: A graphic and statistical analysis in infants and children. Can. Anaesth. Soc J. 1983; 30: 360-9.
39. Cooper J, Medow N, Dibble C. Mortality rate in strabismus surgery. J. Am. Optom. Soc. 1982; 53: 391-5.
40. Berntson GG, Cacioppo JT, Quigley KS. Autonomic determinism: The modes of autonomic control, the doctrine of autonomic space, and the laws of autonomic constraint. Psychol. Rev. 1991; 98: 459-87.
41. Marshall JM. The heart. In: Mountcastle V (ed.). Medical Physiology. CV Mosby, St Louis. 1974; 849-82.
42. Lundberg JM. Enkephalin, substance P, VIP, somatostatin, gastrin/CCK and neurotensin in peripheral neurones. Acta Physiol. Scand. 1979; 469: S14.
43. Lundberg JM, Hokfelt T, Kewenter J. Substance P-, VIP- and enkephalin-like immunoreactivity in the human vagus nerve. Gastroenterology 1979; 77: 468-71.
44. Lundberg JM, Hoekfelt T, Schultzberg M. Occurrence of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in certain cholinergic neurons of the cat: Evidence from combined immunohistochemistry and acetylcholinesterase staining. Neuroscience 1979; 4: 1539-59.
45. Lundberg JM, Terenius L, Hokfelt T, Goldstein M. High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci. Lett. 1983; 42: 167-72.
46. Warton J, Polak JM, McGregor GP. The distribution of substance P-like immunoreactive nerves in the guinea-pig heart. Neuroscience 1981; 6: 2193-204.
47. Haroutunian V, Campbell BA. Neural control of the heart-rate-orienting response in preweanling rats. Behav. Neural Biol. 1982; 36: 24-39.
48. Beaulieu P, Lambert C. Peptidic regulation of heart rate and interactions with the autonomic nervous system. Cardiovasc. Res. 1998; 37: 578-85.
49. Franco-Cereceda A, Nagata M, Svensson TH, Lundberg JM. Differential effects of clonidine and reserpine treatment on neuropeptide Y content in some sympathetically innervated tissues of the guinea-pig. Eur. J. Pharmacol. 1987; 142: 267-73.
50. Levy MN, Warner MR. Autonomic interactions in cardiac control: role of neuropeptides. In: Zipes DP, Jalife J (eds). Cardiac Electrophysiology from Cell to Bedside. Saunders, Philadelphia. 1990; 305-11.
51. Lundberg JM. Pharmacology of cotransmission in the autonomic nervous system: Integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide. Pharmacol. Rev. 1996; 48: 113-78.
52. Levy MN. Sympathetic-parasympathetic interactions in the heart. Circ. Res. 1971; 29: 437-45.
53. Boscan PCh, Allen AM, Paton JFR. Baroreflex inhibition of cardiac sympathetic outflow is attenuated by angiotensin II in the solitary tract nucleus. Neuroscience 2001; 103: 153-60.
54. Mirakhur RK, Jones CJ, Dundee JW, Archer DB. I.m. or i.v. atropine or glycopyrrolate for the prevention of oculocardiac reflex in children undergoing squint surgery. Br. J. Anaesth. 1982; 54: 1059-63.