Does the inactivation of leukocytes in blood transfusions during and following liver transplantation by gamma-irradiation have an impact on rejection and infection rate?

Medical Science Monitor

Volumn 12, Issue 12, 2006, Pages

  Ott, Rudolf ^a   Bussenius Kammerer, Michaela ^b   Reck, Thomas ^b   Hering, Constanze ^c   Müller, Volker ^b   Riese, Jutta ^d,e   Koch, Christian A ^a,f  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b Knappschaftskrankenhaus Puettlingen ^*

^c Klinikum Hof   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e UNIVERSITY OF APPLIED SCIENCES   (Germany)

^f UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Blood transfusion; Gamma irradiation; Infection; Leukocytes; Liver transplantation; Rejection

Indexed keywords

C REACTIVE PROTEIN; CD45RO ANTIGEN; CD8 ANTIGEN; FRESH FROZEN PLASMA; GLUCOCORTICOID; LIPOPOLYSACCHARIDE BINDING PROTEIN; PREDNISOLONE; TACROLIMUS;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; BLOOD TRANSFUSION; CD4 CD8 RATIO; CELL ISOLATION; CELL SEPARATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; GAMMA IRRADIATION; GRAFT DYSFUNCTION; GRAFT REJECTION; HUMAN; INFECTION RATE; LEUKOCYTE; LEUKOCYTE ACTIVATION; LIVER CIRRHOSIS; LIVER FUNCTION TEST; LIVER TRANSPLANTATION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; POSTOPERATIVE CARE; POSTOPERATIVE INFECTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; THROMBOCYTE; TREATMENT DURATION;

ADULT; BLOOD TRANSFUSION; FEMALE; GAMMA RAYS; GRAFT REJECTION; HUMANS; INFECTION; LEUKOCYTE REDUCTION PROCEDURES; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; T-LYMPHOCYTE SUBSETS;

EID: 33845484641     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Cacciarelli TV, Keeffe EB, Moore DH et al: Effect of intraoperative blood transfusion on patient outcome in hepatic transplantation. Arch Surg, 1999; 134(1): 25-29
2. Bennett-Guerrero E, Feierman DE, Barclay GR et al: Preoperative and intraoperative predictors of postoperative morbidity, poor graft function, and early rejection in 190 patients undergoing liver transplantation. Arch Surg, 2001; 136(10): 1177-83
3. Ramos E, Dalmau A, Sabate A et al: Intraoperative red blood cell transfusion in liver transplantation: influence on patient outcome, prediction of requirements, and measures to reduce them. Liver Transpl, 2003; 9(12): 1320-27
4. Brand A: Immunological aspects of blood transfusions. Blood Rev, 2000; 14: 130-44
5. Houbiers JG, Brand A, van de Watering LM et al: Randomised controlled trial comparing transfusion of leucocyte-depleted or buffy-coat-depleted blood in surgery for colorectal cancer. Lancet, 1994; 344: 573-78
6. Scheele J, Altendorf-Hofmann A, Grube T et al: Resection of colorectal liver metastases. What prognostic factors determine patient selection? Chirurg, 2001; 72(5): 547-60
7. Tartter PI, Mohandas K, Azar P et al: Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgery. Am J Surg, 1998; 176(5): 462-66
8. Vignali A, Braga M, Gianotti L et al: A single unit of transfused allogeneic blood increases postoperative infections. Vox Sang, 1996; 71(3): 170-75
9. van Hilten JA, van de Watering LM, van Bockel JH et al: Effects of transfusion with red cells filtered to remove leucocytes: randomised controlled trial in patients undergoing major surgery. BMJ, 2004; 328: 1281
10. Vamvakas EC: Meta-analysis of randomized controlled trials investigating the risk of postoperative infection in association with white blood cell-containing allogeneic blood transfusion: the effects of the type of transfused red blood cell product and surgical setting. Transfus Med Rev, 2002; 16(4): 304-14
11. Wallis JP, Chapman CE, Orr KE et al: Effect of WBC reduction of transfused RBCs on postoperative infection rates in cardiac surgery. Transfusion, 2002; 42(9): 1127-34
12. Roddie PH, Turner ML, Williamson LM: Leucocyte depletion of blood components. Blood Rev, 2000; 14: 145-56
13. Jensen LS, Hokland ME, Nielsen HJ: Leukocyte filtration in elective colorectal surgery. Reduced transfusion associated immunosuppression after bedside procedures. Ugeskr Laeger, 1997; 159(34): 5093-97
14. Lee Th, Paglieroni T, Ohto H et al: Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. Blood, 1999; 93: 3127-39
15. Sproul AM, Chalmers EA, Mills KI et al: Third party mediated graft rejection despite irradiation of blood products. Br J Haematol, 1992; 80: 251-52
16. Togashi K, Nakazawa S, Moro H: The effects of transfusion of irradiated blood upon cellular immune response in patients underwent open heart surgery. Nippon Kyobu Geka Gakkai Zasshi, 1989; 37: 1958-64
17. Tanaka S: Prevention of post-transfusion graft versus host disease by irradiating blood products with X-ray or gamma-ray. Nippon Rinsho, 1997; 55: 2277-81
18. Landi EP, de Oliveira JS: Transfusion-associated graft-versus-host disease guideline on gamma irradiation of blood components. Rev Assoc Med Bras, 1999; 45: 261-72
19. Przepiorka D, LeParc GF, Stovall MA et al: Use of irradiated blood components: practice parameter. Am J Clin Pathol, 1996; 106: 6-11
20. Williamson LM, Warwick RM: Transfusion-associated graft-versus-host disease and its prevention. Blood Rev, 1995; 9: 251-61
21. Davey RJ: Transfusion-associated graft-versus-host disease and the irradiation of blood components. Immunol Invest, 1995; 24: 431-34
22. Eiermann TH: Indications for irradiated blood components: dose and side effects. Beitr Infusionsther, 1993; 31: 70-73
23. Seghatchian MJ, Ala F: Transfusion-associated graft-versus-host disease: current concepts and future trends. Transfus Sci, 1995; 16: 99-105
24. Ohto H, Suzuki H, Abe R: Graft-versus-host disease: introduction and prospect. Fukushima J Med Sci, 1993; 39: 63-67
25. Klein HG: Transfusion in transplant patients: the good, the bad, and the ugly. J Heart Lung Transplant, 1993; 12: S7-12
26. Handa M: Prevention of posttransfusion graft-versus-host disease by leukocyte depletion filter. Nippon Rinsho, 1997; 55: 2282-89
27. Ott R, Gralka S, Froschauer R et al: Low rejection rate after hepatic transplantation achieved with a cyclosporine-based quadruple immunosuppressive regimen. Transplant Proc, 1998; 30(4): 1427-29
28. European FK506 Multicentre Liver Study Group: Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. Lancet, 1994; 344: 423-28
29. Neuhaus P, Blumhardt G, Bechstein WO et al: Technique and results of biliary reconstruction using side-to-side choledochocholedochostomy in 300 orthotopic liver transplants. Ann Surg, 1994; 219(4): 426-34
30. Batts KP: Acute and chronic hepatic allograft rejection: pathology and classification. Liver Transpl Surg, 1999; 5(Suppl.4): S21-29
31. Panel IW: Teminology for hepatic allograft rejection. International Working Party. Hepatology, 1995; 22(2): 648-54
32. Davenport M, Peakman M, Dunne JB: Peripheral blood and intrahepatic subsets of T lymphocyte activation and function in liver allograft rejection and drug-induced tolerance in rats. Transpl Immunol, 1996; 4: 126-32
33. Fast LD: Recipient CD8+ cells are responsible for the rapid elimination of allogenic donor lymphoid cells. J Immunology, 1996; 157: 4805-10
34. Lee JH, Klein HG: From leukocyte reduction to leucocyte transfusion: the immunological effects of transfused leukocytes. Baillieres Best Pract Res Clin Hematol, 2000; 13: 585-600
35. Kreisel D, Petrowsky H, Krasinkas AM et al: Third-party passenger leukocytes prolong liver allograft survival. Transplant Proc, 2001; 33(1-2): 171-72
36. Drobyski W, Thibodeau S, Truitt RL: Third-party-mediated graft rejection and graft-versus-host disease after T-cell-depleted bone marrow transplantation, as demonstrated by hypervariable DNA probes and HLA-DR polymorphism. Blood, 1989; 74: 2285-94
37. Walter M, Dammann G, Kuchenhoff J et al: Psychological situation of living donors: moods, complaints, and self-image before and after liver transplantation. Med Sci Monit, 2005; 11(11): CR503-9
38. Vater Y, Levy A, Martay K et al: Adjuvant drugs for end-stage liver failure and transplantation. Med Sci Monit, 2004; 10(4): RA77-88
39. Crosbie OM, Norris S, Hegarty JE, O'Farrelly C: T lymphocyte subsets and activation status in patients following liver transplantation. Immunol Invest, 1998; 27: 237-41
40. Perdigoto R, Paiva A, Freitas A: Peripheral blood lymphocyte phenotype can predict rejection episodes after orthotopic liver transplantation. Transplant Proc, 1999; 31: 2418-20
41. Winkler M, Schwinzer R, Wonigeit K et al: Analysis of CD45RA- CD45RO+ "memory" T cells in patients after kidney, heart, and liver transplantation. Transplant Proc, 1992; 24: 2532-34
42. Perkins JD: Acute cellular rejection rates in living-donor and deceased-donor liver transplantation. Liver Transpl, 2006; 12: 886-87
43. Liu LU, Bodian CA, Gondolesi GE et al: Marked differences in acute cellular rejection rates between living-donor and deceased-donor liver transplant recipients. Transplantation, 2005; 80: 1072-80
44. Yilmaz F, Azdin U, Nart D et al: The incidence and management of acute and chronic rejection after living donor liver transplantation. Transplant Proc, 2006; 38: 1435-37
45. Sanfilippo FP, Bollinger RR, MacQueen JM et al: A randomized study comparing leukocyte-depleted versus packed red cell transfusions in prospective cadaver renal allograft recipients. Transfusion, 1985; 25(2): 116-19