Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients

World Journal of Gastroenterology

Volumn 12, Issue 45, 2006, Pages 7319-7325

  Decaens, Thomas ^a   Roudot Thoraval, Françoise ^a   Bresson Hadni, Solange ^b   Meyer, Carole ^c   Gugenheim, Jean ^d   Durand, Francois ^e   Bernard, Pierre Henri ^f   Boillot, Olivier ^g   Compagnon, Philippe ^h   Calmus, Yvon ⁱ   Hardwigsen, Jean ^j   Ducerf, Christian ^k   Pageaux, Georges Philippe ^l   Dharancy, Sébastien ^m   Chazouillères, Olivier ⁿ   Cherqui, Daniel ^a   Duvoux, Christophe ^a  

^a HENRI MONDOR HOSPITAL   (France)

^b UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

^c HÔPITAL DE HAUTEPIERRE   (France)

^d CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^e BEAUJON HOSPITAL   (France)

^f HÔPITAL PELLEGRIN   (France)

^g EDOUARD HERRIOT HOSPITAL   (France)

^h PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

ⁱ Hôpital Cochin ^*  (France)

^j HÔPITAL DE LA CONCEPTION   (France)

^k CROIX ROUSSE HOSPITAL   (France)

^l HÔPITAL SAINT ELOI   (France)

^m LILLE UNIVERSITY HOSPITAL   (France)

ⁿ HÔPITAL SAINT ANTOINE   (France)

more..

Author keywords

Hepatocellular carcinoma; Immunosuppression; Liver transplantation; Tumor differentiation

Indexed keywords

ALPHA FETOPROTEIN; ANTINEOPLASTIC AGENT; CALCINEURIN INHIBITOR; CYCLOSPORIN A; GAMMA GLUTAMYLTRANSFERASE; LYMPHOCYTE ANTIBODY; METHYLPREDNISOLONE; OKT 3; TACROLIMUS;

ARTICLE; CANCER RECURRENCE; CANCER SIZE; CANCER SURVIVAL; CHEMOEMBOLIZATION; DISEASE FREE SURVIVAL; ENZYME ACTIVITY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PORTAL VEIN THROMBOSIS; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PROGNOSIS; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; RISK FACTOR; SURVIVAL RATE; SURVIVAL TIME;

EID: 33845473092     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i45.7319     Document Type: Article

References (31)

1. El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999; 340: 745-750
2. Deuffic S, Poynard T, Buffat L, Valleron AJ. Trends in primary liver cancer. Lancet 1998; 351: 214-215
3. Taylor-Robinson SD, Foster GR, Arora S, Hargreaves S, Thomas HC. Increase in primary liver cancer in the UK, 1979-94. Lancet 1997; 350: 1142-1143
4. Olthoff KM. Surgical options for hepatocellular carcinoma: resection and transplantation. Liver Transpl Surg 1998; 4: S98-S104
5. Iwatsuki S, Gordon RD, Shaw BW Jr, Starzl TE. Role of liver transplantation in cancer therapy. Ann Surg 1985; 202: 401-407
6. O'Grady JG, Polson RJ, Rolles K, Calne RY, Williams R. Liver transplantation for malignant disease. Results in 93 consecutive patients. Ann Surg 1988; 207: 373-379
7. Ringe B, Wittekind C, Bechstein WO, Bunzendahl H, Pichlmayr R. The role of liver transplantation in hepatobiliary malignancy. A retrospective analysis of 95 patients with particular regard to tumor stage and recurrence. Ann Surg 1989; 209: 88-98
8. Ismail T, Angrisani L, Gunson BK, Hubscher SG, Buckels JA, Neuberger JM, Elias E, McMaster P. Primary hepatic malignancy: the role of liver transplantation. Br J Surg 1990; 77: 983-987
9. Ringe B, Pichlmayr R, Wittekind C, Tusch G. Surgical treatment of hepatocellular carcinoma: experience with liver resection and transplantation in 198 patients. World J Surg 1991; 15: 270-285
10. Bismuth H, Chiche L, Adam R, Castaing D, Diamond T, Dennison A. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg 1993; 218:145-151
11. Iwatsuki S, Starzl TE, Sheahan DG, Yokoyama I, Demetris AJ, Todo S, Tzakis AG, Van Thiel DH, Carr B, Selby R. Hepatic resection versus transplantation for hepatocellular carcinoma. Ann Surg 1991; 214: 221-228; discussion 228-229
12. McPeake JR, O'Grady JG, Zaman S, Portmann B, Wight DG, Tan KC, Calne RY, Williams R. Liver transplantation for primary hepatocellular carcinoma: tumor size and number determine outcome. J Hepatol 1993; 18: 226-234
13. Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, Montalto F, Ammatuna M, Morabito A, Gennari L. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334: 693-699
14. Marsh JW, Dvorchik I, Subotin M, Balan V, Rakela J, Popechitelev EP, Subbotin V, Casavilla A, Carr BI, Fung JJ, Iwatsuki S. The prediction of risk of recurrence and time to recurrence of hepatocellular carcinoma after orthotopic liver transplantation: a pilot study. Hepatology 1997; 26: 444-450
15. Klintmalm GB. Liver transplantation for hepatocellular carcinoma: a registry report of the impact of tumor characteristics on outcome. Ann Surg 1998; 228: 479-490
16. Molmenti EP, Klintmalm GB. Liver transplantation in association with hepatocellular carcinoma: an update of the International Tumor Registry. Liver Transpl 2002; 8: 736-748
17. Jonas S, Bechstein WO, Steinmuller T, Herrmann M, Radke C, Berg T, Settmacher U, Neuhaus P. Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 2001; 33: 1080-1086
18. Iwatsuki S, Dvorchik I, Marsh JW, Madariaga JR, Carr B, Fung JJ, Starzl TE. Liver transplantation for hepatocellular carcinoma: a proposal of a prognostic scoring system. J Am Coll Surg 2000; 191: 389-394
19. Yao FY, Ferrell L, Bass NM, Watson JJ, Bacchetti P, Venook A, Ascher NL, Roberts JP. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 2001; 33: 1394-1403
20. Tamura S, Kato T, Berho M, Misiakos EP, O'Brien C, Reddy KR, Nery JR, Burke GW, Schiff ER, Miller J, Tzakis AG. Impact of histological grade of hepatocellular carcinoma on the outcome of liver transplantation. Arch Surg 2001; 136: 25-30; discussion 31
21. Vivarelli M, Bellusci R, Cucchetti A, Cavrini G, De Ruvo N, Aden AA, La Barba G, Brillanti S, Cavallari A. Low recurrence rate of hepatocellular carcinoma after liver transplantation: better patient selection or lower immunosuppression? Transplantation 2002; 74: 1746-1751
22. Karnofsky DA. Palliation and life prolongation with anticancer drugs. CA Cancer J Clin 1966; 16: 117-119
23. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646-649
24. American Liver Tumor Study Group. A randomized prospective multi-institutional trial of orthotopic liver transplantation or partial hepatic resection with or without adjuvant chemotherapy for hepatocellular carcinoma. In Investigator Booklet and Protocol, 1998
25. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7: 462-503
26. Yokoyama I, Carr B, Saitsu H, Iwatsuki S, Starzl TE. Accelerated growth rates of recurrent hepatocellular carcinoma after liver transplantation. Cancer 1991; 68: 2095-2100
27. Ceriello A, Mezza F, Cozzolino S, Pettinato G, Mancini A, Santaniello W, Calise F, Cuomo O. Role of immunosuppression in recurrence after liver transplantation for diethylnitrosamine-induced tumors in rats. Transpl Int 1994; 7 Suppl 1: S204-S207
28. Freise CE, Ferrell L, Liu T, Ascher NL, Roberts JP. Effect of systemic cyclosporine on tumor recurrence after liver transplantation in a model of hepatocellular carcinoma. Transplantation 1999; 67: 510-513
29. Cillo U, Vitale A, Bassanello M, Boccagni P, Brolese A, Zanus G, Burra P, Fagiuoli S, Farinati F, Rugge M, D'Amico DF. Liver transplantation for the treatment of moderately or well-differentiated hepatocellular carcinoma. Ann Surg 2004; 239: 150-159
30. Takamori R, Wong LL, Dang C, Wong L. Needle-tract implantation from hepatocellular cancer: is needle biopsy of the liver always necessary? Liver Transpl 2000; 6: 67-72
31. Chapoutot C, Perney P, Fabre D, Taourel P, Bruel JM, Larrey D, Domergue J, Ciurana AJ, Blanc F. Needle-tract seeding after ultrasound-guided puncture of hepatocellular carcinoma. A study of 150 patients. Gastroenterol Clin Biol 1999; 23: 552-556