The effects of short-term hypoxia on motor cortex excitability and neuromuscular activation

Journal of Applied Physiology

Volumn 101, Issue 6, 2006, Pages 1673-1677

  Szubski, Christoph ^a   Burtscher, Martin ^a   Löscher, Wolfgang N ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Cortical silent period; Transcranial magnetic stimulation; Voluntary activation

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; EVOKED MUSCLE RESPONSE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; MOTOR CORTEX; MOTOR PERFORMANCE; MUSCLE EXCITATION; MYOELECTRICITY; NORMAL HUMAN; PRIORITY JOURNAL; TRANSCRANIAL MAGNETIC STIMULATION;

ADAPTATION, PHYSIOLOGICAL; ADULT; ANOXIA; EVOKED POTENTIALS, MOTOR; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; MUSCLE, SKELETAL; NEUROMUSCULAR JUNCTION; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 33845459158     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00617.2006     Document Type: Article

References (50)

1. Amassian VE, Stewart M, Quirk GJ, and Rosenthal JL. Physiological basis of motor effects of a transient stimulus to cerebral cortex. Neurosurgery 20: 74-93, 1987.
2. Badier M, Guillot C, Lagier-Tessonnier F, and Jammes Y. EMG changes in respiratory and skeletal muscles during isometric contraction under normoxic, hypoxemic, or ischemic conditions. Muscle Nerve 17: 500-508, 1994.
3. Boroojerdi B, Battaglia F, Muellbacher W, and Cohen LG. Mechanisms influencing stimulus-response properties of the human corticospinal system. Clin Neurophysiol 112: 931-937, 2001.
4. O2 values during short-term exposure to hypoxia. High Alt Med Biol 5: 335-340, 2004.
5. Cantello R, Gianelli M, Civardi C, and Mutani R. Magnetic brain stimulation: the silent period after the motor evoked potential. Neurology 42: 1951-1959, 1992.
6. Caquelard F, Burnet H, Tagliarini F, Cauchy E, Richalet JP, and Jammes Y. Effects of prolonged hypobaric hypoxia on human skeletal muscle function and electromyographic events. Clin Sci (Lond) 98: 329-337, 2000.
7. Chen R, Lozano AM, and Ashby P. Mechanism of the silent period following transcranial magnetic stimulation. Evidence from epidural recordings. Exp Brain Res 128: 539-542, 1999.
8. Chen R, Samii A, Canos M, Wassermann EM, and Hallett M. Effects of phenytoin on cortical excitability in humans. Neurology 49: 881-883, 1997.
9. Degens H, Sanchez Horneros JM, and Hopman MT. Acute hypoxia limits endurance but does not affect muscle contractile properties. Muscle Nerve 33: 532-537, 2006.
10. Devanne H, Lavoie BA, and Capaday C. Input-output properties and gain changes in the human corticospinal pathway. Exp Brain Res 114: 329-338, 1997.
11. Di Lazzaro V, Restuccia D, Oliviero A, Profice P, Ferrara L, Insola A, Mazzone P, Tonali P, and Rothwell JC. Effects of voluntary contraction on descending volleys evoked by transcranial stimulation in conscious humans. J Physiol 508: 625-633, 1998.
12. 2 deprivation: in vitro intracellular studies. Am J Physiol Lung Cell Mol Physiol 262: L549-L554, 1992.
13. Eiken O and Tesch PA. Effects of hyperoxia and hypoxia on dynamic and sustained static performance of the human quadriceps muscle. Acta Physiol Scand 122: 629-633, 1984.
14. Esposito F, Orizio C, Parrinello G, and Veicsteinas A. Chronic hypobaric hypoxia does not affect electro-mechanical muscle activities during sustained maximal isometric contractions. Eur J Appl Physiol 90: 337-343, 2003.
15. Fowler B and Kelso B. The effects of hypoxia on components of the human event-related potential and relationship to reaction time. Aviat Space Environ Med 63: 510-516, 1992.
16. Fowler B and Lindeis AE. The effects of hypoxia on auditory reaction time and P300 latency. Aviat Space Environ Med 63: 976-981, 1992.
17. o. J Neurosci 13: 63-72, 1993.
18. Fuhr P, Agostino R, and Hallett M. Spinal motor neuron excitability during the silent period after cortical stimulation. Electroencephalogr Clin Neurophysiol 81: 257-262, 1991.
19. Fulco CS, Cymerman A, Muza SR, Rock PB, Pandolf KB, and Lewis SF. Adductor pollicis muscle fatigue during acute and chronic altitude exposure and return to sea level. J Appl Physiol 77: 179-183, 1994.
20. Fulco CS, Lewis SF, Frykman PN, Boushel R, Smith S, Harman EA, Cymerman A, and Pandolf KB. Muscle fatigue and exhaustion during dynamic leg exercise in normoxia and hypobaric hypoxia. J Appl Physiol 81: 1891-1900, 1996.
21. Garner SH, Sutton JR, Burse RL, McComas AJ, Cymerman A, and Houston CS. Operation Everest II: neuromuscular performance under conditions of extreme simulated altitude. J Appl Physiol 68: 1167-1172, 1990.
22. 2 deprivation in the central nervous system: on mechanisms of neuronal response, differential sensitivity and injury. Prog Neurobiol 40: 277-318, 1993.
23. Hepple RT. Skeletal muscle: microcirculatory adaptation to metabolic demand. Med Sci Sports Exerc 32: 117-123, 2000.
24. Hornbein TF. Long term effects of high altitude on brain function. Int J Sports Med 13, Suppl 1: 43-45, 1992.
25. Hornbein TF, Townes BD, Schoene RB, Sutton JR, and Houston CS. The cost to the central nervous system of climbing to extremely high altitude. N Engl J Med 321: 1714-1719, 1989.
26. Inghilleri M, Berardelli A, Cruccu G, and Manfredi M. Silent period evoked by transcranial stimulation of the human cortex and cervicomedullary junction. J Physiol 466: 521-534, 1993.
27. Inghilleri M, Berardelli A, Marchetti P, and Manfredi M. Effects of diazepam, baclofen and thiopental on the silent period evoked by transcranial magnetic stimulation in humans. Exp Brain Res 109: 467-472, 1996.
28. Kayser B, Bokenkamp R, and Binzoni T. Alpha-motoneuron excitability at high altitude. Eur J Appl Physiol Occup Physiol 66: 1-4, 1993.
29. Kennedy RS, Dunlap WP, Banderet LE, Smith MG, and Houston CS. Cognitive performance deficits in a simulated climb of Mount Everest: Operation Everest II. Aviat Space Environ Med 60: 99-104, 1989.
30. Kimiskidis VK, Papagiannopoulos S, Sotirakoglou K, Kazis DA, Kazis A, and Mills KR. Silent period to transcranial magnetic stimulation: construction and properties of stimulus-response curves in healthy volunteers. Exp Brain Res 163: 21-31, 2005.
31. Kobayashi M, Theoret H, Mottaghy FM, Gangitano M, and Pascual-Leone A. Intracortical inhibition and facilitation in human facial motor area: difference between upper and lower facial area. Clin Neurophysiol 112: 1604-1611, 2001.
32. Lieberman P, Protopapas A, Reed E, Youngs JW, and Kanki BG. Cognitive defects at altitude. Nature 372: 325, 1994.
33. Lopez-Barneo J. Oxygen-sensing by ion channels and the regulation of cellular functions. Trends Neurosci 19: 435-440, 1996.
34. Lopez-Barneo J, Pardal R, and Ortega-Saenz P. Cellular mechanism of oxygen sensing. Annu Rev Physiol 63: 259-287, 2001.
35. Luhmann HJ and Heinemann U. Hypoxia-induced functional alterations in adult rat neocortex. J Neurophysiol 67: 798-811, 1992.
36. Luhmann HJ, Kral T, and Heinemann U. Influence of hypoxia on excitation and GABAergic inhibition in mature and developing rat neocortex. Exp Brain Res 97: 209-224, 1993.
37. Lukyanetz EA, Shkryl VM, Kravchuk OV, and Kostyuk PG. Effect of hypoxia on calcium channels depends on extracellular calcium in CA1 hippocampal neurons. Brain Res 980: 128-134, 2003.
38. Maeda F, Gangitano M, Thall M, and Pascual-Leone A. Inter- and intra-individual variability of paired-pulse curves with transcranial magnetic stimulation (TMS). Clin Neurophysiol 113: 376-382, 2002.
39. 3H]flunitrazepam in the rat brain under hypoxia. J Neurochem 51: 1111-1117, 1988.
40. Oliviero A, Corbo G, Tonali PA, Pilato F, Saturno E, Dileone M, Versace V, Valente S, and Di Lazzaro V. Functional involvement of central nervous system in acute exacerbation of chronic obstructive pulmonary disease. A preliminary transcranial magnetic stimulation study. J Neurol 249: 1232-1236, 2002.
41. Orizio C, Esposito F, and Veicsteinas A. Effect of acclimatization to high altitude (5,050 m) on motor unit activation pattern and muscle performance. J Appl Physiol 77: 2840-2844, 1994.
42. Parolin ML, Spriet LL, Hultman E, Hollidge-Horvat MG, Jones NL, and Heigenhauser GJ. Regulation of glycogen phosphorylase and PDH during exercise in human skeletal muscle during hypoxia. Am J Physiol Endocrinol Metab 278: E522-E534, 2000.
43. Shephard RJ. Physiological changes and psychomotor performance during acute hypoxia. J Appl Physiol 9: 343-351, 1956.
44. Viapiano MS, Mitridate de Novara AM, Fiszer de Plazas S, and Bozzini CE. Prolonged exposure to hypobaric hypoxia transiently reduces GABA(A) receptor number in mice cerebral cortex. Brain Res 894: 31-36, 2001.
45. Werhahn KJ, Kunesch E, Noachtar S, Benecke R, and Classen J. Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans. J Physiol 517: 591-597, 1999.
46. Willer JC, Miserocchi G, and Gautier H. Hypoxia and monosynaptic reflexes in humans. J Appl Physiol 63: 639-645, 1987.
47. Young A, Wright J, Knapik J, and Cymerman A. Skeletal muscle strength during exposure to hypobaric hypoxia. Med Sci Sports Exerc 12: 330-335, 1980.
48. Ziemann U, Lonnecker S, and Paulus W. Inhibition of human motor cortex by ethanol. A transcranial magnetic stimulation study. Brain 118: 1437-1446, 1995.
49. Ziemann U, Lonnecker S, Steinhoff BJ, and Paulus W. The effect of lorazepam on the motor cortical excitability in man. Exp Brain Res 109: 127-135, 1996.
50. Ziemann U, Lonnecker S, Steinhoff BJ, and Paulus W. Effects of antiepileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study. Ann Neurol 40: 367-378, 1996.