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Volumn 291, Issue 6, 2006, Pages

Desensitization of the pancreatic β-cell: Effects of sustained physiological hyperglycemia and potassium

Author keywords

Desensitization; Hyperglycemia; Hyperkalemia; Islets; Secretion

Indexed keywords

CARBACHOL; FATTY ACID; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INOSITOL PHOSPHATE; PHOSPHOLIPASE C; POTASSIUM;

EID: 33845454784     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00137.2006     Document Type: Article
Times cited : (10)

References (51)
  • 1
    • 0015371351 scopus 로고
    • A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties
    • Albano JDM, Ekins RP, Maritz G, and Turner RC. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol 70: 487-509, 1972.
    • (1972) Acta Endocrinol , vol.70 , pp. 487-509
    • Albano, J.D.M.1    Ekins, R.P.2    Maritz, G.3    Turner, R.C.4
  • 2
    • 0020644646 scopus 로고
    • 2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets
    • 2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets. J Clin Invest 72: 13-21, 1983.
    • (1983) J Clin Invest , vol.72 , pp. 13-21
    • Axen, K.V.1    Schubart, U.K.2    Blake, A.D.3    Fleischer, N.4
  • 3
    • 0018924227 scopus 로고
    • Different dynamics of insulin secretion in the perfused pancreas of the mouse and rat
    • Berglund O. Different dynamics of insulin secretion in the perfused pancreas of the mouse and rat. Acta Endocrinol 93: 54-60, 1980.
    • (1980) Acta Endocrinol , vol.93 , pp. 54-60
    • Berglund, O.1
  • 4
    • 0020595443 scopus 로고
    • Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides
    • Berridge MJ, Dawson RMC, Downes CP, Heslop JP, and Irvine RP. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J 212: 473-482, 1983.
    • (1983) Biochem J , vol.212 , pp. 473-482
    • Berridge, M.J.1    Dawson, R.M.C.2    Downes, C.P.3    Heslop, J.P.4    Irvine, R.P.5
  • 5
    • 0022525054 scopus 로고
    • A role for calcium in the breakdown of inositiol phospholipids in intact and digitonin-permeabilized pancreatic islets
    • Best L. A role for calcium in the breakdown of inositiol phospholipids in intact and digitonin-permeabilized pancreatic islets. Biochem J 238: 773-779, 1986.
    • (1986) Biochem J , vol.238 , pp. 773-779
    • Best, L.1
  • 6
    • 0023250613 scopus 로고
    • 2+-mediated generation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets
    • 2+-mediated generation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. J Biol Chem 262: 3567-3571, 1987.
    • (1987) J Biol Chem , vol.262 , pp. 3567-3571
    • Biden, T.J.1    Peter-Riesch, B.2    Schlegel, W.3    Wollheim, C.B.4
  • 7
    • 0027450505 scopus 로고
    • B-cell insensitivity in vitro: Reversal by diazoxide entails more than one event in stimulus-secretion coupling
    • Björklund A and Grill V. B-cell insensitivity in vitro: reversal by diazoxide entails more than one event in stimulus-secretion coupling. Endocrinology 132: 1319-1328, 1993.
    • (1993) Endocrinology , vol.132 , pp. 1319-1328
    • Björklund, A.1    Grill, V.2
  • 8
    • 0022621813 scopus 로고
    • The third phase of in vitro insulin secretion. Evidence for glucose insensitivity
    • Bolaffi JL, Heldt A, Lewis LD, and Grodsky GM. The third phase of in vitro insulin secretion. Evidence for glucose insensitivity. Diabetes 35: 370-373, 1986.
    • (1986) Diabetes , vol.35 , pp. 370-373
    • Bolaffi, J.L.1    Heldt, A.2    Lewis, L.D.3    Grodsky, G.M.4
  • 9
    • 0023947320 scopus 로고
    • Characteristics of desensitization of insulin secretion in fully in vitro systems
    • Bolaffi JL, Bruno Z, Heldt A, and Grodsky GM. Characteristics of desensitization of insulin secretion in fully in vitro systems. Endocrinology 122: 1801-1809, 1988.
    • (1988) Endocrinology , vol.122 , pp. 1801-1809
    • Bolaffi, J.L.1    Bruno, Z.2    Heldt, A.3    Grodsky, G.M.4
  • 10
    • 0025996840 scopus 로고
    • The role of Ca2+-related events in glucose-stimulated desensitization of insulin secretion
    • Bolaffi JL, Rodd GG, Ma YH, Bright D, and Grodsky GM. The role of Ca2+-related events in glucose-stimulated desensitization of insulin secretion. Endocrinology 129: 2131-2138, 1991.
    • (1991) Endocrinology , vol.129 , pp. 2131-2138
    • Bolaffi, J.L.1    Rodd, G.G.2    Ma, Y.H.3    Bright, D.4    Grodsky, G.M.5
  • 12
    • 0022645730 scopus 로고
    • Insulin content and insulinogenesis by the perfused rat pancreas: Effects of long term glucose stimulation
    • Curry DL. Insulin content and insulinogenesis by the perfused rat pancreas: effects of long term glucose stimulation. Endocrinology 118: 170-175, 1986.
    • (1986) Endocrinology , vol.118 , pp. 170-175
    • Curry, D.L.1
  • 13
    • 0023130739 scopus 로고
    • Gastro-intestinal peptides and insulin secretion
    • Ebert R and Creutzfeldt W. Gastro-intestinal peptides and insulin secretion. Diabetes Metab Rev 3: 1-26, 1987.
    • (1987) Diabetes Metab Rev , vol.3 , pp. 1-26
    • Ebert, R.1    Creutzfeldt, W.2
  • 14
    • 0027199747 scopus 로고
    • The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus
    • Elahi D, Muller DC, McAloon-Dyke M, Tobin JD, and Andres R. The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus. Exp Gerontol 28: 393-409, 1993.
    • (1993) Exp Gerontol , vol.28 , pp. 393-409
    • Elahi, D.1    Muller, D.C.2    McAloon-Dyke, M.3    Tobin, J.D.4    Andres, R.5
  • 15
    • 0030043092 scopus 로고    scopus 로고
    • In praise of the hyperglycemic clamp: A method for assessment of B-cell sensitivity and insulin resistance
    • Elahi D. In praise of the hyperglycemic clamp: a method for assessment of B-cell sensitivity and insulin resistance. Diabetes Care 19: 278-286, 1996.
    • (1996) Diabetes Care , vol.19 , pp. 278-286
    • Elahi, D.1
  • 16
    • 0016256203 scopus 로고
    • Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas
    • Gerich JE, Charles MA, and Grodsky GM. Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas. J Clin Invest 54: 833-841, 1974.
    • (1974) J Clin Invest , vol.54 , pp. 833-841
    • Gerich, J.E.1    Charles, M.A.2    Grodsky, G.M.3
  • 17
    • 4143057100 scopus 로고    scopus 로고
    • Loss of beta cell function as fasting glucose increases in the non-diabetic range
    • Godsland IF, Jeffs JAR, and Johnston DG. Loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47: 1157-1166, 2004.
    • (2004) Diabetologia , vol.47 , pp. 1157-1166
    • Godsland, I.F.1    Jeffs, J.A.R.2    Johnston, D.G.3
  • 18
    • 0015605434 scopus 로고
    • Potassium stimulation of insulin release by the perfused rat pancreas
    • Gomez M and Curry DL. Potassium stimulation of insulin release by the perfused rat pancreas. Endocrinology 92: 1126-1134, 1973.
    • (1973) Endocrinology , vol.92 , pp. 1126-1134
    • Gomez, M.1    Curry, D.L.2
  • 19
    • 0018148325 scopus 로고
    • Immediate and time-dependent effects of glucose on insulin release from rat pancreatic tissue
    • Grill V, Adamson U, and Cerasi E. Immediate and time-dependent effects of glucose on insulin release from rat pancreatic tissue. J Clin Invest 61: 1034-1043, 1978.
    • (1978) J Clin Invest , vol.61 , pp. 1034-1043
    • Grill, V.1    Adamson, U.2    Cerasi, E.3
  • 20
    • 0015381760 scopus 로고
    • A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling
    • Grodsky GM. A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling. J Clin Invest 51: 2047-2059, 1972.
    • (1972) J Clin Invest , vol.51 , pp. 2047-2059
    • Grodsky, G.M.1
  • 21
    • 0024807859 scopus 로고
    • A new phase of insulin secretion. How will it contribute to our understanding of β-cell function?
    • Grodsky GM. A new phase of insulin secretion. How will it contribute to our understanding of β-cell function? Diabetes 38: 673-678, 1989.
    • (1989) Diabetes , vol.38 , pp. 673-678
    • Grodsky, G.M.1
  • 22
    • 0019984298 scopus 로고
    • Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli
    • Henquin JC, Charles S, Nenquin M, Mathot F, and Tamagawa T. Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli. Diabetes 31: 776-783, 1982.
    • (1982) Diabetes , vol.31 , pp. 776-783
    • Henquin, J.C.1    Charles, S.2    Nenquin, M.3    Mathot, F.4    Tamagawa, T.5
  • 23
    • 0023253774 scopus 로고
    • Distinct mechanisms for two amplification systems of insulin release
    • Henquin JC, Bozem M, Schmeer W, and Nenquin M. Distinct mechanisms for two amplification systems of insulin release. Biochem J 246: 393-399, 1987.
    • (1987) Biochem J , vol.246 , pp. 393-399
    • Henquin, J.C.1    Bozem, M.2    Schmeer, W.3    Nenquin, M.4
  • 24
    • 0028797017 scopus 로고
    • Synergistic interaction of glucose and neurohumoral agonists to stimulate islet phosphoinositide hydrolysis
    • Kelley GG, Zawalich KC, and Zawalich WS. Synergistic interaction of glucose and neurohumoral agonists to stimulate islet phosphoinositide hydrolysis. Am J Physiol Endocrinol Metab 269: E575-E582, 1995.
    • (1995) Am J Physiol Endocrinol Metab , vol.269
    • Kelley, G.G.1    Zawalich, K.C.2    Zawalich, W.S.3
  • 27
    • 0030055324 scopus 로고    scopus 로고
    • Metabolic signaling of insulin secretion
    • Malaisse WJ. Metabolic signaling of insulin secretion. Diabetes Rev 4: 145-159, 1996.
    • (1996) Diabetes Rev , vol.4 , pp. 145-159
    • Malaisse, W.J.1
  • 28
    • 0021800609 scopus 로고
    • Stimulation by glucose and carbamylcholine of phospholipase C in pancreatic islets
    • Mathias PCF, Best L, and Malaisse WJ. Stimulation by glucose and carbamylcholine of phospholipase C in pancreatic islets. Cell Biochem Funct 3: 173-177, 1985.
    • (1985) Cell Biochem Funct , vol.3 , pp. 173-177
    • Mathias, P.C.F.1    Best, L.2    Malaisse, W.J.3
  • 30
    • 0016201668 scopus 로고
    • Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas
    • Pagliara AS, Stillings SN, Hover B, Martin DM, and Matschinsky FM. Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas. J Clin Invest 54: 819-832, 1974.
    • (1974) J Clin Invest , vol.54 , pp. 819-832
    • Pagliara, A.S.1    Stillings, S.N.2    Hover, B.3    Martin, D.M.4    Matschinsky, F.M.5
  • 31
    • 0026654469 scopus 로고
    • Regulation of inositol phospholipid-specific phospholipase C isozymes
    • Rhee SG and Choi KD. Regulation of inositol phospholipid-specific phospholipase C isozymes. J Biol Chem 267: 12393-12396, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 12393-12396
    • Rhee, S.G.1    Choi, K.D.2
  • 32
    • 0030995012 scopus 로고    scopus 로고
    • Regulation of phosphoinositide-specific phospholipase C isozymes
    • Rhee SG and Bae YS. Regulation of phosphoinositide-specific phospholipase C isozymes. J Biol Chem 272: 15045-15048, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 15045-15048
    • Rhee, S.G.1    Bae, Y.S.2
  • 36
    • 0025647505 scopus 로고
    • Dose-response characteristics for glucose-stimulated insulin release in man and assessment of influence of glucose on arginine-stimulated insulin release
    • Van Haeften TW, Boonstra E, Veneman TF, Gerich JE, and van der Veen EA. Dose-response characteristics for glucose-stimulated insulin release in man and assessment of influence of glucose on arginine-stimulated insulin release. Metabolism 39: 1292-1299, 1990.
    • (1990) Metabolism , vol.39 , pp. 1292-1299
    • Van Haeften, T.W.1    Boonstra, E.2    Veneman, T.F.3    Gerich, J.E.4    Van Der Veen, E.A.5
  • 37
    • 33644876114 scopus 로고    scopus 로고
    • Acute and chronic effects of glucose and carbachol on insulin secretion and phospholipase C activation: Studies with diazoxide and atropine
    • Yamazaki H, Philbrick W, Zawalich KC, and Zawalich WS. Acute and chronic effects of glucose and carbachol on insulin secretion and phospholipase C activation: studies with diazoxide and atropine. Am J Physiol Endocrinol Metab 290: E26-E33, 2006.
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Yamazaki, H.1    Philbrick, W.2    Zawalich, K.C.3    Zawalich, W.S.4
  • 38
    • 0023606449 scopus 로고
    • Cholecystokinin-induced alterations in beta-cell sensitivity. Duration, specificity, and involvement of phosphoinositide metabolism
    • Zawalich WS, Diaz VA, and Zawalich KC. Cholecystokinin-induced alterations in beta-cell sensitivity. Duration, specificity, and involvement of phosphoinositide metabolism. Diabetes 36: 1420-1424, 1987.
    • (1987) Diabetes , vol.36 , pp. 1420-1424
    • Zawalich, W.S.1    Diaz, V.A.2    Zawalich, K.C.3
  • 39
    • 0023573056 scopus 로고
    • Interactions of cholecystokinin and glucose in rat pancreatic islets
    • Zawalich WS, Takuwa N, Takuwa Y, Diaz VA, and Rasmussen H. Interactions of cholecystokinin and glucose in rat pancreatic islets. Diabetes 36: 426-433, 1987.
    • (1987) Diabetes , vol.36 , pp. 426-433
    • Zawalich, W.S.1    Takuwa, N.2    Takuwa, Y.3    Diaz, V.A.4    Rasmussen, H.5
  • 40
    • 0023841431 scopus 로고
    • Modulation of insulin secretion from beta-cells by phosphoinositide- derived second-messenger molecules
    • (Review)
    • Zawalich WS. Modulation of insulin secretion from beta-cells by phosphoinositide-derived second-messenger molecules (Review). Diabetes 37: 137-141, 1988.
    • (1988) Diabetes , vol.37 , pp. 137-141
    • Zawalich, W.S.1
  • 41
    • 0024162529 scopus 로고
    • 3H]inositol efflux, inositol phosphate accumulation, and insulin release from isolated rat islets
    • 3H]inositol efflux, inositol phosphate accumulation, and insulin release from isolated rat islets. Diabetes 37: 1478-1483, 1988.
    • (1988) Diabetes , vol.37 , pp. 1478-1483
    • Zawalich, W.S.1    Diaz, V.A.2    Zawalich, K.C.3
  • 42
    • 0024397177 scopus 로고
    • Phosphoinositide hydrolysis and insulin secretion in response to glucose stimulation are impaired in isolated rat islets by prolonged exposure to the sulfonylurea tolbutamide
    • Zawalich WS. Phosphoinositide hydrolysis and insulin secretion in response to glucose stimulation are impaired in isolated rat islets by prolonged exposure to the sulfonylurea tolbutamide. Endocrinology 125: 281-286, 1989.
    • (1989) Endocrinology , vol.125 , pp. 281-286
    • Zawalich, W.S.1
  • 43
    • 0024601002 scopus 로고
    • 3H]inositol alter the subsequent responses of these islets to a high glucose concentration
    • 3H]inositol alter the subsequent responses of these islets to a high glucose concentration. Biochem J 259: 743-749, 1989.
    • (1989) Biochem J , vol.259 , pp. 743-749
    • Zawalich, W.S.1    Zawalich, K.C.2    Rasmussen, H.3
  • 44
    • 0025398105 scopus 로고
    • Multiple effects of increases in phosphoinositide hydrolysis on islets and their relationship to changing patterns of insulin secretion
    • Zawalich WS. Multiple effects of increases in phosphoinositide hydrolysis on islets and their relationship to changing patterns of insulin secretion. Diabetes Res 13: 101-111, 1990.
    • (1990) Diabetes Res , vol.13 , pp. 101-111
    • Zawalich, W.S.1
  • 45
    • 0025371908 scopus 로고
    • Forskolin-induced desensitization of pancreatic β-cell insulin secretory responsiveness: Possible involvement of impaired information flow in the inositol-lipid cycle
    • Zawalich WS and Zawalich KC. Forskolin-induced desensitization of pancreatic β-cell insulin secretory responsiveness: possible involvement of impaired information flow in the inositol-lipid cycle. Endocrinology 126: 2307-2312, 1990.
    • (1990) Endocrinology , vol.126 , pp. 2307-2312
    • Zawalich, W.S.1    Zawalich, K.C.2
  • 46
    • 0026636002 scopus 로고
    • Glucosamine-induced desensitization of beta-cell responses: Possible involvement of impaired information flow in the phosphoinositide cycle
    • Zawalich WS and Zawalich KC. Glucosamine-induced desensitization of beta-cell responses: possible involvement of impaired information flow in the phosphoinositide cycle. Endocrinology 130: 3135-3142, 1992.
    • (1992) Endocrinology , vol.130 , pp. 3135-3142
    • Zawalich, W.S.1    Zawalich, K.C.2
  • 47
    • 0027160176 scopus 로고
    • Comparative effects of monomethylsuccinate and glucose on insulin secretion from perifused rat islets
    • Zawalich WS, Zawalich KC, Cline G, Shulman G, and Rasmussen H. Comparative effects of monomethylsuccinate and glucose on insulin secretion from perifused rat islets. Diabetes 42: 843-850, 1993.
    • (1993) Diabetes , vol.42 , pp. 843-850
    • Zawalich, W.S.1    Zawalich, K.C.2    Cline, G.3    Shulman, G.4    Rasmussen, H.5
  • 48
    • 0028791470 scopus 로고
    • Effects of short term culturing on islet phosphoinositide and insulin secretory responses to glucose and carbachol
    • Zawalich WS, Zawalich KC, and Kelley GG. Effects of short term culturing on islet phosphoinositide and insulin secretory responses to glucose and carbachol. Acta Diabetol 32: 158-164, 1995.
    • (1995) Acta Diabetol , vol.32 , pp. 158-164
    • Zawalich, W.S.1    Zawalich, K.C.2    Kelley, G.G.3
  • 49
    • 0029862867 scopus 로고    scopus 로고
    • Species differences in the induction of time dependent potentiation of insulin secretion
    • Zawalich WS and Zawalich KC. Species differences in the induction of time dependent potentiation of insulin secretion. Endocrinology 137: 1664-1669, 1996.
    • (1996) Endocrinology , vol.137 , pp. 1664-1669
    • Zawalich, W.S.1    Zawalich, K.C.2


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