An efficient synthesis of 1,6- and 1,7-dibromo-3-aminoisoquinolines: versatile templates for the preparation of functionalized isoquinolines

Tetrahedron Letters

Volumn 48, Issue 3, 2007, Pages 487-489

  Frohn, Mike ^a   Bürli, Roland W ^a   Riahi, Bobby ^a   Hungate, Randall W ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 DIBROMO 3 AMINOISOQUINOLINE DERIVATIVE; 1,7 DIBROMO 3 AMINOISOQUINOLINE DERIVATIVE; ISOQUINOLINE DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 33845454138     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.11.035     Document Type: Article

References (27)

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16. 3) δ ppm 135.21, 134.14, 132.39, 132.34, 128.88, 115.84, 115.25, 110.98, 22.35.
17. In one case, small amounts of nitrile hydrolysis were also observed (10-15% by LC/MS analysis).
18. Preliminary experiments showed that continuous addition of HBr (g) was required for the reaction to proceed.
19. Minor amounts of nitrile hydrolysis was also observed.
20. 3) δ ppm 156.23, 142.71, 141.40, 130.03, 126.62, 126.15, 125.16, 119.73, 96.63.
21. 2O, (B) 0.1% TFA in MeCN, 10-100% B in 10 min).
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