Changes in Abdominal Wounds Following Treatment With Sirolimus and Steroids in a Rat Model

Transplantation Proceedings

Volumn 38, Issue 10, 2006, Pages 3331-3332

  Gaber, M W ^a   Aziz, A M ^a   Shang, X ^a   Penmetsa, R ^a   Sabek, O M ^a   Yen, M R T ^a   Gaber, L W ^a   Moore, L W ^a   Gaber, A O ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAPAMYCIN; STEROID;

ABDOMINAL INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; INCISION; LOADING DRUG DOSE; LOW DRUG DOSE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; TENSILE STRENGTH; WOUND CLOSURE; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ABDOMINAL INJURIES; ADRENAL CORTEX HORMONES; ANIMALS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MODELS, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; SIROLIMUS; TENSILE STRENGTH; WOUND HEALING;

EID: 33845447749     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.10.047     Document Type: Article

References (8)

1. Guilbeau J.M. Delayed wound healing with sirolimus after liver transplant. Ann Pharmacother 36 (2002) 1391
2. Langer R.M., and Kahan B.D. Incidence, therapy, and consequences of lymphocele after sirolimus-cyclosporine-prednisone immunosuppression in renal transplant recipients. Transplantation 74 (2002) 804
3. Dean P.G., Lund W.J., Larson T.S., et al. Wound-healing complications after kidney transplantation: a prospective, randomized comparison of sirolimus and tacrolimus. Transplantation 77 (2004) 1555
4. Oberbauer R., Kreis H., Johnson R.W., et al. Long-term improvement in renal function with sirolimus after early cyclosporine withdrawal in renal transplant recipients: 2-year results of the Rapamune Maintenance Regimen Study. Transplantation 76 (2003) 364
5. Troppmann C., Pierce J.L., Gandhi M.M., et al. Higher surgical wound complication rates with sirolimus immunosuppression after kidney transplantation: a matched-pair pilot study. Transplantation 76 (2003) 426
6. Akselband Y., Harding M.W., and Nelson P.A. Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts. Transplant Proc 23 (1991) 2833
7. Transplant Advisory Board on Wound Healing in Rapamycin Treated Patients. Chicago, Illinois, USA, October 2002
8. Franz M.G., Smith P.D., Wachtel T.L., et al. Fascial incisions heal faster than skin: a new model of abdominal wall repair. Surgery 129 (2001) 203