Transcardiac adiponectin gradient is independently related to endothelial vasomotor function in large and resistance coronary arteries in humans

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 6, 2006, Pages

  Takano, Hajime ^a   Kodama, Yasushi ^a   Kitta, Yoshinobu ^a   Nakamura, Takamitsu ^a   Obata, Jyun Ei ^a   Mende, Akira ^a   Kawabata, Ken Ichi ^a   Saitoh, Yukio ^a   Fujioka, Daisuke ^a   Kobayashi, Tsuyoshi ^a   Hasebe, Hideyuki ^a   Kugiyama, Kiyotaka ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Acetylcholine; Coronary artery spasm; Coronary circulation; Endothelium; Microvascular angina

Indexed keywords

ACETYLCHOLINE; ADIPONECTIN; ISOSORBIDE DINITRATE; NITROPRUSSIDE SODIUM;

ADULT; AGED; ANGINA PECTORIS; ANGIOCARDIOGRAPHY; AORTA ROOT; ARTICLE; BLOOD VESSEL DIAMETER; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; CORRELATION ANALYSIS; ENDOTHELIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPICARDIUM; FEMALE; HEART LEFT VENTRICLE; HEART VENTRICULOGRAPHY; HUMAN; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MAJOR CLINICAL STUDY; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; PRESSURE GRADIENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SYNDROME X; VASODILATATION; VASOMOTOR REFLEX;

ADIPONECTIN; AGED; ANGINA PECTORIS; CASE-CONTROL STUDIES; CORONARY CIRCULATION; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MICROVASCULAR ANGINA; MIDDLE AGED; MYOCARDIUM; REGIONAL BLOOD FLOW; VASCULAR RESISTANCE; VASOMOTOR SYSTEM;

EID: 33845440864     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00702.2006     Document Type: Article

References (23)

1. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shiomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, and Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257: 79-83, 1999.
2. Botker HE, Frobert O, Moller N, Christiansen E, Schmitz O, and Bagger JP. Insulin resistance in cardiac syndrome X and variant angina: influence of physical capacity and circulating lipids. Am Heart J 134: 229-237, 1997.
3. Cannon RO III, Camici PG, and Epstein SE. Pathophysiological dilemma of syndrome X. Circulation 85: 883-892, 1992.
4. Chen H, Montagnani M, Funahashi T, Shimomura I, and Quon MJ. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278: 45021-45026, 2003.
5. Crea F and Lanza GA. Angina pectoris and normal coronary arteries: cardiac syndrome X. Heart 90: 457-463, 2004.
6. Date H, Imamura T, Ideguchi T, Kawagoe J, Sumi T, Masuyama H, Onitsuka H, Ishikawa T, Nagoshi T, and Eto T. Adiponectin produced in coronary circulation regulates coronary flow reserve in nondiabetic patients with angiographically normal coronary arteries. Clin Cardiol 29: 211-214, 2006.
7. Fujioka D, Kawabata K, Saito Y, Kobayashi T, Nakamura T, Kodama Y, Takano H, Obata JE, Kitta Y, Umetani K, and Kugiyama K. Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart. Am J Physiol Heart Circ Physiol 290: H2409-H2416, 2006.
8. Furuhashi M, Ura N, Moniwa N, Shinshi Y, Kouzu H, Nishihara M, Kokubu N, Takahashi T, Sakamoto K, Hayashi M, Satoh N, Nishitani T, Shikano Y, and Shimamoto K. Possible impairment of transcardiac utilization of adiponectin in patients with Type 2 diabetes. Diabetes Care 27: 2217-2221, 2004.
9. Hirashima O, Kawano H, Motoyama T, Hirai N, Ohgushi M, Kugiyama K, Ogawa H, and Yasue H. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species. J Am Coll Cardiol 35: 1860-1866, 2000.
10. Ichigi Y, Takano H, Umetani K, Kawabata K, Obata JE, Kitta Y, Kodama Y, Mende A, Nakamura T, Fujioka D, Saito Y, and Kugiyama K. Increased ambulatory pulse pressure is a strong risk factor for coronary endothelial vasomotor dysfunction. J Am Coll Cardiol 45: 1461-1466, 2005.
11. Inobe Y, Kugiyama K, Morita E, Kawano H, Okumura K, and Tomiguchi S. Role of adenosine in pathogenesis of syndrome X: assessment with coronary hemodynamic measurements and thallium-201 myocardial single-photon emission computed tomography. J Am Coll Cardiol 28: 890-896, 1996.
12. Kaski JC. Pathophysiology and management of patients with chest pain and normal coronary arteriograms (cardiac syndrome X). Circulation 109: 568-572, 2004.
13. Kugiyama K, Yasue H, Okumura K, Ogawa H, Fujimoto K, Nakao K, Yoshimura M, Motoyama T, Inobe Y, and Kawano H. Nitric oxide activity is deficient in spasm arteries of patients with co ronary spastic angina. Circulation 94: 266-271, 1996.
14. Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, Kuriyama H, Hotta K, Nakamura T, Shimomura I, and Matsuzawa Y. PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50: 2094-2099, 2001.
15. Matsuzawa Y, Funahashi T, Kihara S, and Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 24: 29-33, 2004.
16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, and Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
17. Matuda M, Shiomura I, Ouchi N, Sata M, Arita Y, Nishida M, Maeda N, Kumada M, Okamoto Y, Nagaretani H, Nishizawa H, Kishida K, Komuro R, Ouchi N, Kihara S, Nagai R, Funahashi T, and Matsuzawa Y. Role of adiponectin in preventing vascular stenosis. J Biol Chem 277: 37487-37491, 2002.
18. Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, Ohashi K, Sakai N, Shiomura I, Kobayashi H, Terasaka N, Inaba T, Funahashi T, and Matsuzawa Y. Adiponectin reduces atherosclerosis in adiponectin E-deficient mice. Circulation 106: 2767-2770, 2002.
19. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, and Matsuzawa Y. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102: 1296-1301, 2000.
20. Tan KC, Xu A, Chow WS, Lam MC, Ai VH, Tam SC, and Lam KS. Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab 89: 765-769, 2004.
21. Tobias P, Cynthia JG, Gokhan SH, Nader R, Frank BH, and Eric BR. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 291: 1730-1737, 2004.
22. Yasue H and Kugiyama K. Coronary spasm: clinical features and pathogenesis. Intern Med 36: 760-765, 1997.
23. Yasue H, Yoshimura M, Sumida H, Kikuta K, Kugiyama K, Jougasaki M, Ogawa H, Okumura K, Mukoyama M, and Nakao K. Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure. Circulation 90: 195-203, 1994.