Synthesis of 1,4-diphenylbutadiene derivatives: Novel inducer of tissue-type plasminogen activator (t-PA) in cultured bovine endothelial cells

Chemical and Pharmaceutical Bulletin

Volumn 54, Issue 12, 2006, Pages 1686-1693

  Sai, Hiroshi ^a   Ogiku, Tsuyoshi ^a   Ohmizu, Hiroshi ^a   Ohtani, Akio ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Cross coupling reaction; Dipheylbutadiene derivative; Plasminogen activator; Plasminogen activator inhibitor 1; Stereoselective olefin synthesis; Stobbe condensation

Indexed keywords

1,4 DIPHENYLBUTADIENE DERIVATIVE; 3 (3 NITROBENZYLIDENE) 4 (3,4,5 TRIMETHOXYBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 3 (4 CHLOROBENZYLIDENE) 4 (3,4,5 TRIMETHOXYBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 3 (4 DIMETHYLAMINOBENZYLIDENE) 4 (3,4,5 TRIMETHOXYBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 3 (4 METHOXYBENZYLIDENE) 4 (3,4,5 TRIMETHOXYBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 3 BENZYLIDENE 1 METHYL 4 (3,4,5 TRIMETHOXYBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 3 BENZYLIDENE 4 (3 NITROBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 3 BENZYLIDENE 4 (3,4,5 TRIMETHOXYBENZYLIDENE)DIHYDROFURAN 2 ONE; 3 BENZYLIDENE 4 (3,4,5 TRIMETHOXYBENZYLIDENE)DIHYDROFURAN 2,5 DIONE; 3 BENZYLIDENE 4 (3,4,5 TRIMETHOXYBENZYLIDENE)PYRROLIDIN 2 ONE; 3 BENZYLIDENE 4 (3,4,5 TRIMETHOXYBENZYLIDENE)SUCCINIMIDE; 3 BENZYLIDENE 4 (4 CHLOROBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 3 BENZYLIDENE 4 (4 DIMETHYLAMINOBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 3 BENZYLIDENE 4 (4 METHOXYBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 3 BENZYLIDINE 4 (3,4 DIMETHOXYBENZYLIDENE)PYRROLIDINE 2,5 DIONE; 4 BENZYLIDENE 3 (3,4,5 TRIMETHOXYBENZYLIDENE)DIHYDROFURAN 2 ONE; 4 BENZYLIDENE 3 (3,4,5 TRIMETHOXYBENZYLIDENE)PYRROLIDIN 2 ONE; METHYL 2 BENZYLIDENE 3 CARBAMOYL 4 (3,4,5 TRIMETHOXYPHENYL)BUT 3 ENOATE; METHYL 3 (2 HYDROXYETHYLCARBAMOYL) 4 PHENYL 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BUT 3 ENOATE; METHYL 3 BENZYLCARBAMOYL 4 PHENYL 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BUT 3 ENOATE; METHYL 3 CARBAMOYL 4 (3,4 DIMETHOXYPHENYL) 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BUT 3 ENOATE; METHYL 3 CARBAMOYL 4 (4 DIMETHYLAMINOPHENYL) 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BUT 3 ENOATE; METHYL 3 CARBAMOYL 4 (4 METHOXYPHENYL) 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BUT 3 ENOATE; METHYL 3 CARBAMOYL 4 PHENYL 2 (3,4,5 TRIMETHOXYBENZYLIDENE) BUT 3 ENOATE; METHYL 3 HYDRAZINOCARBONYL 4 PHENYL 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BUT 3 ENOATE; METHYL 3 METHOXYCARBAMOYL 4 PHENYL 3 (3,4,5 TRIMETHOXYBENZYLIDENE)BUT 3 ENOATE; METHYL 3 METHYLCARBAMOYL 4 PHENYL 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BUT 3 ENOATE; SUCCINIMIDE DERIVATIVE; TISSUE PLASMINOGEN ACTIVATOR; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG ACTIVITY; DRUG INHIBITION; DRUG SYNTHESIS; ENDOTHELIUM CELL; FIBRINOLYSIS; NONHUMAN; RAT; STEREOISOMERISM; THROMBOGENESIS; VASCULAR ENDOTHELIUM; VEIN THROMBOSIS;

ANIMALS; BUTADIENES; CATTLE; ENDOTHELIAL CELLS; MOLECULAR STRUCTURE; PLASMINOGEN ACTIVATORS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE PLASMINOGEN ACTIVATOR;

EID: 33845426504     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.54.1686     Document Type: Article

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