The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage

Neurological Research

Volumn 28, Issue 8, 2006, Pages 859-863

  Sen, Orhan ^a   Caner, Hakan ^a   Aydin, M Volkan ^a   Ozen, Ozlem ^a   Atalay, Basar ^a   Altinors, Nur ^a   Bavbek, Murad ^a  

^a BASKENT UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Mexiletine; Subarachnoid hemorrhage

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM CHANNEL; FREE RADICAL; MEXILETINE; PEROXIDASE; SODIUM CHANNEL; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BASILAR ARTERY; BRAIN VASOSPASM; CELL PROTECTION; CONTROLLED STUDY; DEVICE; DRUG POTENCY; ENDOTHELIUM; ENDOTHELIUM CELL; LIPID PEROXIDATION; NONHUMAN; PATHOGENESIS; RABBIT; SINGLE DRUG DOSE; SUBARACHNOID HEMORRHAGE; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; APOPTOSIS; ARTERIES; DISEASE MODELS, ANIMAL; ENDOTHELIUM; IN SITU NICK-END LABELING; LIPID PEROXIDATION; MEXILETINE; RABBITS; RANDOM ALLOCATION; SUBARACHNOID HEMORRHAGE;

EID: 33845410078     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164106X115099     Document Type: Article

References (23)

1. Foley PL, Takenaka K, Kassell NF, et al. Cytotoxic effects of bloody cerebrospinal fluid on cerebral endothelial cells in culture. J Neurosurg 1994; 81: 87-92
2. Meguro T, Chen B, Lancon J, et al. Oxyhemoglobin induces caspase-mediated cell death in cerebral endothelial cells. J Neurochem 2001; 77: 1128-1135
3. Ogihara K, Zubkov AY, Bernanke DH, et al. Oxyhemoglobin-induced apoptosis in cultured endothelial cells. J Neurosurg 1999; 91: 459-465
4. Takenaka K, Kassell NF, Foley PL, et al. Oxyhemoglobin-induced cytotoxicity and arachidonic acid release in cultured bovine endothelial cells. Stroke 1993; 24: 839-845
5. Zubkov AY, Ogihara K, Bernanke DH, et al. Apoptosis of endothelial cells in vessels affected by cerebral vasospasm. Surg Neurol 2000; 53: 260-266
6. Macdonald RL, Weir BK. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 1991; 22: 971-982
7. Kamezaki T, Yanaka K, Nagase S, et al. Increased levels of lipid peroxides as predictive of symptomatic vasospasm and poor outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg 2002; 97: 1302-1305
8. Halliwell B, Gutteridge JM. Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts. Arch Biochem Biophys 1986; 246: 501-514
9. Mayberg MR, Okada T, Bark DH. The significance of morphological changes in cerebral arteries after subarachnoid hemorrhage. J Neurosurg 1990; 72: 626-633
10. Findlay JM, Weir BK, Kanamaru K, et al. Arterial wall changes in cerebral vasospasm. Neurosurgery 1989; 25: 736-745
11. Aoki K, Zubkov AY, Ross IB, et al. Therapeutic effect of caspase inhibitors in the prevention of apoptosis and reversal of chronic cerebral vasospasm. J Clin Neurosci 2002; 9: 672-677
12. Monk JP, Brodgen RN. Mexilitine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias. Drugs 1990; 40: 374-411
13. Demirpence D, Caner H, Bavbek M, et al. Antioxidant action of the antiarrhytmic drug mexiletine in brain membranes. Jpn J Pharmacol 1999; 81: 7-11
14. Ono K, Kiyosue T, Arita M. Comparison of the inhibitory effects of mexiletine and lidocaine on the calcium current of single ventricular cells. Life Sci 1986; 39: 1465-1470
15. Sato T, Shigematsu S, Arita M. Mexiletine-induced shortening of the action potential duration of ventricular muscles by activation of ATP-sensitive K+ channels. Br J Pharmacol 1995; 115: 381-382
16. Paroczai M, Roth E, Karpati E. Bisaramil and antiarrhythmics as inhibitors of free radical generation. Pharmacol Res 1997; 35: 279-285
17. Caner H, Kwan AL, Bavbek M, et al. Systemic administration of mexiletine for attenuation of cerebral vasospasm following experimental subarachnoid haemorrhage. Acta Neurochir (Wien) 2000; 142: 455-461
18. Caner H, Can A, Atalay B, et al. Early effects of mild brain trauma on the cytoskeletal proteins neurofilaments 160 and MAP2, and the preventive effects of mexiletine. Acta Neurochir (Wien) 2004; 146: 611-621
19. Kaptanoglu E, Caner HH, Surucu SH, et al. Effect of Mexiletine on lipid peroxidation and early ultrastructural findings in experimental spinal cord injury. J Neurosurg 1999; 91: 200-204
20. Mihara M, Uchiyama S. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-278
21. Pasqualin A. Epidemiology and pathophysiology of cerebral vasospasm following subarachnoid hemorrhage. J Neurosurg Sci 1998; 42 (Suppl. 1): S15-S21
22. Liszczak TM, Varsos VG, Black PM, et al. Cerebral arterial constriction after experimental subarachnoid hemorrhage is associated with blood components within the arterial wall. J Neurosurg 1983; 58: 18-26
23. Meguro T, Klett CP, Chen B, et al. Role of calcium channels in oxyhemoglobin-induced apoptosis in endothelial cells. J Neurosurg 2000; 93: 640-646