메뉴 건너뛰기




Volumn 62, Issue 1, 2007, Pages 33-41

A recombinant allergen chimer as novel mucosal vaccine candidate for prevention of multi-sensitivities

Author keywords

Animal model; Mucosal tolerance; Poly sensitization; Recombinant allergen construct; Type I allergy

Indexed keywords

ANTIALLERGIC AGENT; BET V 1 ANTIGEN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G; INTERLEUKIN 10; MESSENGER RNA; PH1 P 1 ANTIGEN; PH1 P 5 ANTIGEN; POLLEN ANTIGEN; RECOMBINANT ANTIGEN; RECOMBINANT VACCINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 33845393785     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2006.01245.x     Document Type: Article
Times cited : (26)

References (39)
  • 1
    • 3042840183 scopus 로고    scopus 로고
    • Immunotherapy: 1999-2004
    • Norman PS. Immunotherapy: 1999-2004. J Allergy Clin Immunol 2004;113:1013-1023.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 1013-1023
    • Norman, P.S.1
  • 2
    • 0029058322 scopus 로고
    • Basic and practical aspects of recombinant allergens
    • Scheiner O, Kraft D. Basic and practical aspects of recombinant allergens. Allergy 1995;50:384-391.
    • (1995) Allergy , vol.50 , pp. 384-391
    • Scheiner, O.1    Kraft, D.2
  • 3
    • 0036242384 scopus 로고    scopus 로고
    • Different methods of local allergen-specific immunotherapy
    • Kagi MK, Wuthrich B. Different methods of local allergen-specific immunotherapy. Allergy 2002;57:379-388.
    • (2002) Allergy , vol.57 , pp. 379-388
    • Kagi, M.K.1    Wuthrich, B.2
  • 5
    • 0036598404 scopus 로고    scopus 로고
    • The future of antigen-specific immunotherapy of allergy
    • Valenta R. The future of antigen-specific immunotherapy of allergy. Nat Rev Immunol 2002;2:446-453.
    • (2002) Nat Rev Immunol , vol.2 , pp. 446-453
    • Valenta, R.1
  • 6
    • 26844540412 scopus 로고    scopus 로고
    • Prophylaxis and therapy of allergy and asthma by mucosal tolerance induction with recombinant allergens or allergen constructs
    • Wiedermann U. Prophylaxis and therapy of allergy and asthma by mucosal tolerance induction with recombinant allergens or allergen constructs. Curr Drug Targets - Inflamm Allergy 2005;4:577-583.
    • (2005) Curr Drug Targets - Inflamm Allergy , vol.4 , pp. 577-583
    • Wiedermann, U.1
  • 7
    • 0032836876 scopus 로고    scopus 로고
    • Suppression of antigen-specific T- And B-cell responses by intranasal or oral administration of recombinant Bet v 1, the major birch pollen allergen, in a murine model of type I allergy
    • Wiedermann U, Jahn-Schmid B, Bohle B, Repa A, Renz H, Kraft D et al. Suppression of antigen-specific T- and B-cell responses by intranasal or oral administration of recombinant Bet v 1, the major birch pollen allergen, in a murine model of type I allergy. J Allergy Clin Immunol 1999;103:1202-1210.
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 1202-1210
    • Wiedermann, U.1    Jahn-Schmid, B.2    Bohle, B.3    Repa, A.4    Renz, H.5    Kraft, D.6
  • 8
    • 0036124728 scopus 로고    scopus 로고
    • Mucosal tolerance as therapy of type I allergy: Intranasal application of recombinant Bet v 1, the major birch pollen allergen, leads to the suppression of allergic immune responses and airway inflammation in sensitized mice
    • Winkler B, Baier K, Wagner S, Repa A, Eichler HG, Scheiner O et al. Mucosal tolerance as therapy of type I allergy: intranasal application of recombinant Bet v 1, the major birch pollen allergen, leads to the suppression of allergic immune responses and airway inflammation in sensitized mice. Clin Exp Allergy 2002;32:30-36.
    • (2002) Clin Exp Allergy , vol.32 , pp. 30-36
    • Winkler, B.1    Baier, K.2    Wagner, S.3    Repa, A.4    Eichler, H.G.5    Scheiner, O.6
  • 9
    • 0032747878 scopus 로고    scopus 로고
    • Age-dependent tendency to become sensitized to other classes of aeroallergens in atopic asthmatic children
    • Silvestri M, Rossi GA, Cozzani S, Pulvirenti G, Fasce L. Age-dependent tendency to become sensitized to other classes of aeroallergens in atopic asthmatic children. Ann Allergy Asthma Immunol 1999;83:335-340.
    • (1999) Ann Allergy Asthma Immunol , vol.83 , pp. 335-340
    • Silvestri, M.1    Rossi, G.A.2    Cozzani, S.3    Pulvirenti, G.4    Fasce, L.5
  • 11
    • 23244456566 scopus 로고    scopus 로고
    • Intranasal tolerance induction with polypeptides derived from 3 non cross-reactive major aeroallergens prevents allergic polysensitization in mice
    • Hufnagl K, Winkler B, Focke M, Valenta R, Scheiner O, Renz H et al. Intranasal tolerance induction with polypeptides derived from 3 non cross-reactive major aeroallergens prevents allergic polysensitization in mice. J Allergy Clin Immunol 2005;116:370-376.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 370-376
    • Hufnagl, K.1    Winkler, B.2    Focke, M.3    Valenta, R.4    Scheiner, O.5    Renz, H.6
  • 12
    • 0031881193 scopus 로고    scopus 로고
    • Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants
    • Akdis CA, Blesken T, Wymann D, Akdis M, Blaser K. Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants. Eur J Immunol 1998;28:914-925.
    • (1998) Eur J Immunol , vol.28 , pp. 914-925
    • Akdis, C.A.1    Blesken, T.2    Wymann, D.3    Akdis, M.4    Blaser, K.5
  • 13
    • 27744576801 scopus 로고    scopus 로고
    • Cell surface recycling of internalized antigen permits dendritic cell priming of B cells
    • Bergtold A, Desai DD, Gavhane A, Clynes R. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 2005;23:503-514.
    • (2005) Immunity , vol.23 , pp. 503-514
    • Bergtold, A.1    Desai, D.D.2    Gavhane, A.3    Clynes, R.4
  • 14
    • 17944365808 scopus 로고    scopus 로고
    • Intranasal treatment with a recombinant hypoallergenic derivative of the major birch pollen allergen Bet v 1 prevents allergic sensitization and airway inflammation in mice
    • Wiedermann U, Herz U, Baier K, Vrtala S, Neuhaus-Steinmetz U, Bohle B et al. Intranasal treatment with a recombinant hypoallergenic derivative of the major birch pollen allergen Bet v 1 prevents allergic sensitization and airway inflammation in mice. Int Arch Allergy Immunol 2001;126:68-77.
    • (2001) Int Arch Allergy Immunol , vol.126 , pp. 68-77
    • Wiedermann, U.1    Herz, U.2    Baier, K.3    Vrtala, S.4    Neuhaus-Steinmetz, U.5    Bohle, B.6
  • 15
    • 33644910900 scopus 로고    scopus 로고
    • The role of Foxp3+ T cells in long-term efficacy of prophylactic and therapeutic mucosal tolerance induction in mice
    • Winkler B, Hufnagl K, Spittler A, Ploder M, Kallay E, Vrtala S et al. The role of Foxp3+ T cells in long-term efficacy of prophylactic and therapeutic mucosal tolerance induction in mice. Allergy 2006;61:173-180.
    • (2006) Allergy , vol.61 , pp. 173-180
    • Winkler, B.1    Hufnagl, K.2    Spittler, A.3    Ploder, M.4    Kallay, E.5    Vrtala, S.6
  • 16
    • 0033082686 scopus 로고    scopus 로고
    • Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors
    • Sheffield P, Garrard S, Derewenda Z. Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors. Protein Expr Purif 1999;15:34-39.
    • (1999) Protein Expr Purif , vol.15 , pp. 34-39
    • Sheffield, P.1    Garrard, S.2    Derewenda, Z.3
  • 17
    • 0042072873 scopus 로고    scopus 로고
    • Cloning and molecular and immunological characterisation of two new food allergens, Cap a 2 and Lyc e 1, profilins from bell pepper (Capsicum annuum) and Tomato (Lycopersicon esculentum)
    • Willerroider M, Fuchs H, Ballmer-Weber BK, Focke M, Susani M, Thalhamer J et al. Cloning and molecular and immunological characterisation of two new food allergens, Cap a 2 and Lyc e 1, profilins from bell pepper (Capsicum annuum) and Tomato (Lycopersicon esculentum). Int Arch Allergy Immunol 2003;131:245-255.
    • (2003) Int Arch Allergy Immunol , vol.131 , pp. 245-255
    • Willerroider, M.1    Fuchs, H.2    Ballmer-Weber, B.K.3    Focke, M.4    Susani, M.5    Thalhamer, J.6
  • 20
    • 0024431870 scopus 로고
    • Monoclonal antibodies against birch pollen allergens: Characterization by immunoblotting and use for single-step affinity purification of the major allergen Bet v 1
    • Jarolim E, Tejkl M, Rohac M, Schlerka G, Scheiner O, Kraft D et al. Monoclonal antibodies against birch pollen allergens: characterization by immunoblotting and use for single-step affinity purification of the major allergen Bet v 1. Int Arch Allergy Appl Immunol 1989;90:54-60.
    • (1989) Int Arch Allergy Appl Immunol , vol.90 , pp. 54-60
    • Jarolim, E.1    Tejkl, M.2    Rohac, M.3    Schlerka, G.4    Scheiner, O.5    Kraft, D.6
  • 21
    • 3042739924 scopus 로고    scopus 로고
    • Influence of the route of sensitization on local and systemic immune responses in a murine model of type I allergy
    • Repa A, Wild C, Hufnagl K, Winkler B, Bohle B, Pollak A et al. Influence of the route of sensitization on local and systemic immune responses in a murine model of type I allergy. Clin Exp Immunol 2004;137:12-18.
    • (2004) Clin Exp Immunol , vol.137 , pp. 12-18
    • Repa, A.1    Wild, C.2    Hufnagl, K.3    Winkler, B.4    Bohle, B.5    Pollak, A.6
  • 22
    • 0242551805 scopus 로고    scopus 로고
    • Allergen-specific immunosuppression by mucosal treatment with recombinant Ves v 5, a major allergen of Vespula vulgaris venom, in a murine model of wasp venom allergy
    • Winkler B, Bolwig C, Seppala U, Spangfort MD, Ebner C, Wiedermann U. Allergen-specific immunosuppression by mucosal treatment with recombinant Ves v 5, a major allergen of Vespula vulgaris venom, in a murine model of wasp venom allergy. Immunology 2003;110:376-385.
    • (2003) Immunology , vol.110 , pp. 376-385
    • Winkler, B.1    Bolwig, C.2    Seppala, U.3    Spangfort, M.D.4    Ebner, C.5    Wiedermann, U.6
  • 24
    • 27144547578 scopus 로고    scopus 로고
    • Molecular design of allergy vaccines
    • Linhart B, Valenta R. Molecular design of allergy vaccines. Curr Opin Immunol 2005;17:646-655.
    • (2005) Curr Opin Immunol , vol.17 , pp. 646-655
    • Linhart, B.1    Valenta, R.2
  • 25
    • 0036676925 scopus 로고    scopus 로고
    • Combination vaccines for the treatment of grass pollen allergy consisting of genetically engineered hybrid molecules with increased immunogenicity
    • Linhart B, Jahn-Schmid B, Verdino P, Keller W, Ebner C, Kraft D et al. Combination vaccines for the treatment of grass pollen allergy consisting of genetically engineered hybrid molecules with increased immunogenicity. Faseb J 2002;16:1301-1303.
    • (2002) Faseb J , vol.16 , pp. 1301-1303
    • Linhart, B.1    Jahn-Schmid, B.2    Verdino, P.3    Keller, W.4    Ebner, C.5    Kraft, D.6
  • 26
    • 0001399408 scopus 로고    scopus 로고
    • Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: Hybrids of yellow jacket and paper wasp venom allergen antigen 5s
    • King TP, Jim SY, Monsalve RI, Kagey-Sobotka A, Lichtenstein LM, Spangfort MD. Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: hybrids of yellow jacket and paper wasp venom allergen antigen 5s. J Immunol 2001;166:6057-6065.
    • (2001) J Immunol , vol.166 , pp. 6057-6065
    • King, T.P.1    Jim, S.Y.2    Monsalve, R.I.3    Kagey-Sobotka, A.4    Lichtenstein, L.M.5    Spangfort, M.D.6
  • 28
    • 27944467811 scopus 로고    scopus 로고
    • Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes
    • Karamloo F, Schmid-Grendelmeier P, Kussebi F, Akdis M, Salagianni M, von Beust BR et al. Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes. Eur J Immunol 2005;35:3268-3276.
    • (2005) Eur J Immunol , vol.35 , pp. 3268-3276
    • Karamloo, F.1    Schmid-Grendelmeier, P.2    Kussebi, F.3    Akdis, M.4    Salagianni, M.5    Von Beust, B.R.6
  • 30
    • 0344197615 scopus 로고    scopus 로고
    • Mapping of T-cell epitopes of Phl p 5: Evidence for crossreacting and non-crossreacting T-cell epitopes within Phl p 5 isoallergens
    • Muller WD, Karamfilov T, Kahlert H, Stuwe HT, Fahlbusch B, Cromwell O et al. Mapping of T-cell epitopes of Phl p 5: evidence for crossreacting and non-crossreacting T-cell epitopes within Phl p 5 isoallergens. Clin Exp Allergy 1998;28:1538-1548.
    • (1998) Clin Exp Allergy , vol.28 , pp. 1538-1548
    • Muller, W.D.1    Karamfilov, T.2    Kahlert, H.3    Stuwe, H.T.4    Fahlbusch, B.5    Cromwell, O.6
  • 31
    • 0029559917 scopus 로고
    • T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): Evidence for crossreacting and non-crossreacting T-cell epitopes within grass group I allergens
    • Schenk S, Breiteneder H, Susani M, Najafian N, Laffer S, Duchene M et al. T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): evidence for crossreacting and non-crossreacting T-cell epitopes within grass group I allergens. J Allergy Clin Immunol 1995;96:986-996.
    • (1995) J Allergy Clin Immunol , vol.96 , pp. 986-996
    • Schenk, S.1    Breiteneder, H.2    Susani, M.3    Najafian, N.4    Laffer, S.5    Duchene, M.6
  • 32
    • 0030802812 scopus 로고    scopus 로고
    • Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: A role for intramolecular epitope suppression
    • Hoyne GF, Jarnicki AG, Thomas WR, Lamb JR. Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: a role for intramolecular epitope suppression. Int Immunol 1997;9:1165-1173.
    • (1997) Int Immunol , vol.9 , pp. 1165-1173
    • Hoyne, G.F.1    Jarnicki, A.G.2    Thomas, W.R.3    Lamb, J.R.4
  • 33
    • 0028858045 scopus 로고
    • An immunogenetic analysis of the T-cell recognition of the major house dust mite allergen der p 2: Identification of high- And low-responder HLA-DQ alleles and localization of T-cell epitopes
    • O'Brien RM, Thomas WR, Nicholson I, Lamb JR, Tait BD. An immunogenetic analysis of the T-cell recognition of the major house dust mite allergen Der p 2: identification of high- and low-responder HLA-DQ alleles and localization of T-cell epitopes. Immunology 1995;86:176-182.
    • (1995) Immunology , vol.86 , pp. 176-182
    • O'Brien, R.M.1    Thomas, W.R.2    Nicholson, I.3    Lamb, J.R.4    Tait, B.D.5
  • 34
    • 8444239271 scopus 로고    scopus 로고
    • Induction of bystander suppression by feeding antigen occurs despite normal clonal expansion of the bystander T cell population
    • Millington OR, Mowat AM, Garside P. Induction of bystander suppression by feeding antigen occurs despite normal clonal expansion of the bystander T cell population. J Immunol 2004;173:6059-6064.
    • (2004) J Immunol , vol.173 , pp. 6059-6064
    • Millington, O.R.1    Mowat, A.M.2    Garside, P.3
  • 35
    • 0026046280 scopus 로고
    • Antigen-driven bystander suppression after oral administration of antigens
    • Miller A, Lider O, Weiner HL. Antigen-driven bystander suppression after oral administration of antigens. J Exp Med 1991;174:791-798.
    • (1991) J Exp Med , vol.174 , pp. 791-798
    • Miller, A.1    Lider, O.2    Weiner, H.L.3
  • 36
    • 0036037685 scopus 로고    scopus 로고
    • Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age
    • Bottcher MF, Haggstrom P, Bjorksten B, Jenmalm MC. Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age. Clin Exp Allergy 2002;32:1293-1298.
    • (2002) Clin Exp Allergy , vol.32 , pp. 1293-1298
    • Bottcher, M.F.1    Haggstrom, P.2    Bjorksten, B.3    Jenmalm, M.C.4
  • 37
    • 0016946588 scopus 로고
    • IgA and IgG anti-ragweed antibodies in nasal secretions. Quantitative measurements of antibodies and correlation with inhibition of histamine release
    • Platts-Mills TA, von Maur RK, Ishizaka K, Norman PS, Lichtenstein LM. IgA and IgG anti-ragweed antibodies in nasal secretions. Quantitative measurements of antibodies and correlation with inhibition of histamine release. J Clin Invest 1976;57:1041-1050.
    • (1976) J Clin Invest , vol.57 , pp. 1041-1050
    • Platts-Mills, T.A.1    Von Maur, R.K.2    Ishizaka, K.3    Norman, P.S.4    Lichtenstein, L.M.5
  • 38
    • 0029959955 scopus 로고    scopus 로고
    • Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance
    • Chen YH, Weiner HL. Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance. Ann N Y Acad Sci 1996;778:111-121.
    • (1996) Ann N Y Acad Sci , vol.778 , pp. 111-121
    • Chen, Y.H.1    Weiner, H.L.2
  • 39
    • 0019161541 scopus 로고
    • Systemic tolerance and secretory immunity after oral immunization
    • Challacombe SJ, Tomasi TB Jr Systemic tolerance and secretory immunity after oral immunization. J Exp Med 1980;152:1459-1472.
    • (1980) J Exp Med , vol.152 , pp. 1459-1472
    • Challacombe, S.J.1    Tomasi Jr., T.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.