Optimizing the rotor design for controlled-shear affinity filtration using computational fluid dynamics

Biotechnology and Bioengineering

Volumn 95, Issue 6, 2006, Pages 1207-1217

  Francis, Patrick ^a,b   Martinez, D Mark ^b   Taghipour, Fariborz ^b   Bowen, Bruce D ^b   Haynes, Charles A ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cell separation; Computational fluid dynamics; Membrane filtration; Module design; Process optimization; Rotating disk filter

Indexed keywords

CELLS; CHROMATOGRAPHIC ANALYSIS; COMPUTATIONAL FLUID DYNAMICS; OPTIMIZATION; PROTEINS; VELOCITY MEASUREMENT;

CELL SEPARATION; MEMBRANE FILTRATION; MODULE DESIGN; ROTATING DISK FILTERS;

ROTORS;

AFFINITY CHROMATOGRAPHY; ARTICLE; CELL CULTURE; CELL MEMBRANE; CELL SURFACE; COMPUTATIONAL FLUID DYNAMICS; HYDRODYNAMICS; PROTEIN ANALYSIS; PROTEIN PURIFICATION; SHEAR STRESS;

ANIMALS; CELL CULTURE TECHNIQUES; CHO CELLS; CHROMATOGRAPHY; COMPUTER SIMULATION; COMPUTERS; CRICETINAE; EQUIPMENT DESIGN; MODELS, THEORETICAL; PROTEINS; RHEOLOGY; SOFTWARE; STRESS, MECHANICAL;

EID: 33845392321     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21090     Document Type: Article

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