Dose-dependent effects of verapamil on ethanol-induced gastric lesions in rats

Journal of Health Science

Volumn 52, Issue 6, 2006, Pages 781-786

  Kiliç, Fatma Sultan ^a   Sirmagül, Basar ^a   Batu, Özlem ^a   Erol, Kevser ^a  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

Author keywords

Ethanol; Gastric lesions; Verapamil

Indexed keywords

ALCOHOL; ARGININE; N(G) NITROARGININE; THIOL GROUP; VERAPAMIL;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MUCUS SECRETION; NONHUMAN; PH MEASUREMENT; RAT; SCORING SYSTEM; STOMACH MUCOSA LESION; STOMACH PROTECTION; STOMACH SECRETION;

ANIMALIA;

EID: 33845390676     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.52.781     Document Type: Article

References (41)

1. Oates, P. J. and Hakkinen, J. P. (1988) Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology, 94, 10-21.
2. Alarcon de la Lastra, A., Lopez, M. J., Martin, et al. (1997) Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds. Pharmacology, 54, 193-202.
3. Koo, M. W. L., Cho, C. H. and Ogle, C. W. (1986) Luminal acid in stress ulceration and the antiulcer action of verapamil in rat stomachs. J. Pharm. Pharmacol., 38, 845-848.
4. Wong, S. H., Cho, C. H. and Ogle, C. W. (1991) Calcium and ethanol-induced gastric mucosal damage in rats. Pharm. Res., 23, 71-79.
5. al-Bekairi A. M., al-Rajhi, A. M. and Tariq, M. (1993) Effect of (+/-)-proprononol and clonidine on stress- and chemically-induced gastric ulcers in rats. Arch. Int. Pharmacodyn. Ther., 323, 97-113.
6. Koo, M. W. L., Cho, C. H. and Ogle, C. W. (1989) The antiulcer effect of verapamil in relation to gastric calcium levels in stressed rats. Pharmacol. Biochem. Behav., 34, 73-76.
7. Glavin, G. B. (1989) Calcium channel modulators : Effects on gastric function. Eur. J. Pharmacol., 160, 323-330.
8. Ulak, G., Cingi, M. I. and Erol, K. (1991) Gastroprotective effect of nitrendipine on stress - induced gastric lesions in rats. Pharmacology, 43, 220-224.
9. 2) on rat gastric damage induced by ethanol in vivo and in vitro. J. Physiol. Pharmacol., 44, 273-281.
10. Lyons, H., Leung, Y. K., Bakri, A., et al. (1992) Verapamil decreases ethanol-induced gastric acid secretion in rats. J. Gastroenterol Hepatol., 7, 48-51.
11. Guttiersez-Cabano, C. A. (1993) Prostaglandins and sulfhydryls may mediate gastric protection induced by verapamil in rats. Dig. Dis. Sci., 38, 2043-2048.
12. Ghanayem, B. I., Matthews, H. B. and Maronpot, R. R. (1987) Calcium channel blockers protect against ethanol- and indomethacin-induced gastric lesions in rats. Gastroenterology, 92, 106-111.
13. Aguwa, C. N. (1984) Effects of exogenous administration of female sex hormones on gastric secretion and ulcer formation in the rat. Eur. J. Pharmacol., 104, 79-84.
14. Suzuki, Y., Hayashi, M., Ito, M. and Yamagami, I. (1976) Antiulcer effects of 4′-(2-Carboxyethyl)phenyl trans-4-aminomethyl cyclohexane carboxylate hydrochloride (Cetraxate) on various experimental gastric ulcers in rats. Jpn. J. Pharmacol., 26, 471-480.
15. Ogle, C. W., Chu, C. C., Tong, M. C. and Koo, M. W. (1985) The influence of verapamil on gastric effects of stress in rats. Eur. J. Pharmacol., 112, 399-404.
16. Corne, S. J., Morrissey, S. M. and Wood, R. J. A. (1974) A method for the quantitive estimation of gastric barrier mucus. J. Physiol. (London), 242, 116-117.
17. Kitagawa, H., Takeda, F. and Kohei, H. (1986) A simple method for estimation of gastric mucus and effects antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats. Arzneim. Forsch., 36, 1240-1244.
18. Sedlak, J. and Lindsay, R. H. (1968) Estimation of total, protein bound and protein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem., 25, 192-205.
19. Utley, H. G., Bernheim, F. and Hochstein, P. (1967) Effects of sulfydryl reagents on peroxidation in microsomes. Arch. Biochem. Biophys., 118, 29-32.
20. Kvietys, P. R., Twohig, B., Danzell, J. and Specian, R. D. (1990) Ethanol-induced injury to the rat gastric mucosa. Role of neutrophils and xanthine oxidase-derived radicals. Gastroenterology, 98, 909-920.
21. Hirota, M., Inoue, M., Ando, Y., Hirayama, K., Morino, Y., Sakamoto, K., Mori, K. and Akagi, M. (1989) Inhibition of stress-induced gastric injury in the rat by glutathione. Gastroenterology, 97, 853-859.
22. Blandizzi, C., Gherardi, G., Marveggio, C., Natale, G., Carignani, D. and Del Tacca, M. (1995) Mechanisms of protection by omeprazole against experimental gastric mucosal damage in rats. Digestion, 56, 220-229.
23. Hojgaard, L., Mertz, N. A. and Rune, S. J. (1996) Peptic ulcer pathophysiology: acid, bicarbonate, and mucosal function. Scand J. Gastroenterol. Suppl., 216, 10-15.
24. Konturek, S. J. (1990) Mechanisms of gastroprotection. Scand J. Gastroenterol Suppl., 174, 15-28.
25. Itoh, M. and Guth, P. H. (1985) Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology, 88, 1162-1167.
26. Chen, K., Inoue, M., Wasa, M., Fukuzova, M., Kamata, S. and Okada, A. (1997) Expression of endothelial constitutive nitric oxide synthase mRNA in gastrointestinal mucosa and its downregulation by endotoxin. Life Sci., 61, 1323-1329.
27. Nishida, K., Ohta, Y. and Ishiguro, I. (1997) Role of gastric mucosal constitutive and inducible nitric oxide synthases in the development of stress-induced gastric mucosal lesions in rats. Biochem. Biophys. Res. Commun., 236, 275-279.
28. Richter, C., Ghafourifar, P., Schweizer, M. and Laffranchi, R. (1997) Nitric oxide and mitochondrial Ca2+. Biochem. Soc. Trans., 25, 914-918.
29. Nahavandi, A., Dehpour, A. R., Mani, A. R., Homayounfar, H. and Abdoli, A. (1999) N(G)-nitro-L-arginine methylester is protective against ethanol-induced gastric damage in cholestatic rats. Eur. J. Pharmacol., 370, 283-286.
30. Nahavandi, A., Mani, A. R., Homayounfar, H., Akbari, M. R. and Dehpour, A. R. (2001) The role of the interaction between endogenous opioids and nitric oxide in the pathophysiology of ethanol-induced gastric damage in cholestatic rats. Fundam. Clin. Pharmacol., 15, 181-187.
31. Tepperman, B. L. and Soper, B. D. (1994) Nitric oxide synthase induction and cytoprotection of rat gastric mucosa from injury by ethanol. Can. J. Physiol. Pharmacol., 72, 1308-1312.
32. Franco, L. (1995) Role of nitric oxide in prevention of ethanol-induced gastric damage by CuNSN a copper-chelating compound. Inflamm. Res., 44, 27-29.
33. Lopez-Belmonte, J., Whittle, B. J. and Moncada, S. (1993) The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa. Br. J. Pharmacol., 108, 73-78.
34. Brown, J. F., Tepperman, B. L., Hanson, P. J. and Whittle, B. J. (1994) Lipopolysaccharide induces Ca(2+)-independent nitric oxide synthase activity in rat gastric mucosal cells. Eur. J. Pharmacol., 292, 111-114.
35. Lamarque, D. and Whittle, B. J. (1995) Involvement of superoxide and xanthine oxidase in neutrophilin-dependent rat gastric damage induced by NO donors. Br. J. Pharmacol., 116, 1843-1848.
36. Hattori, Y., Kasai, K., So, S., Hattori, S., Banba, N. and Shimoda, S. (1995) Effects of calcium channel antogonists on the induction of nitric oxide synthase in cultures cells by immunostimulants. Life Sci., 57, 1833-1840.
37. Djuric, D., Mitrovic, V. and Jakovljevic, V. (2002) The effects of calcium channel antogonists on coronary nitrite outflow in isolated rat heart. Arzneim. Forsch., 52, 365-370.
38. Ding, Y. and Vaziri, N. D. (2000) Nifedipine and diltiazem but not verapamil up-regulate endothelial nitric-oxide synthase expression. JPET, 292, 606-609.
39. Liu, M. Y., Chiong, J. P. J., Hsu, D. Z. and Deng J. F. (2003) Abamectin attenuates gastric mucosal damage induced by ethanol through activation of vagus nerve in rats. Alcohol, 30, 61-65.
40. Dixit, C., Rastogi, L. and Dixit, M. (1999) Effect of nitric-oxide modulators on pylorus-ligation induced ulcers in the rat. Pharmacological Research, 39, 33-39.
41. Koo, J. K. and Cho, C. H. (1999) Co-regulation of mucosal nitric-oxide and prostaglandin in the gastric adaptive cytoprotection. Inflammation Res., 48, 471-478.