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Volumn 18, Issue 12, 2006, Pages 1779-1787

Injection of IL-12- and IL-18-encoding plasmids ameliorates the autoimmune pathology of MRL/Mp-Tnfrsf6lpr mice: Synergistic effect on autoimmune symptoms

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; PLASMID DNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 33845372494     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl112     Document Type: Article
Times cited : (10)

References (49)
  • 1
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A. and Nagata, S. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
    • (1992) Nature , vol.356 , pp. 314
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 2
    • 0642336156 scopus 로고    scopus 로고
    • B lymphocytes and systemic lupus erythematosus
    • Criscione, L. G. and Pisetsky, D. S. 2003. B lymphocytes and systemic lupus erythematosus. Curr. Rheumatol. Rep. 5:264.
    • (2003) Curr. Rheumatol. Rep. , vol.5 , pp. 264
    • Criscione, L.G.1    Pisetsky, D.S.2
  • 3
    • 0142247168 scopus 로고    scopus 로고
    • DNA methylation and autoimmune disease
    • Richardson, B. 2003. DNA methylation and autoimmune disease. Clin. Immunol. 109:72.
    • (2003) Clin. Immunol. , vol.109 , pp. 72
    • Richardson, B.1
  • 4
    • 0037241764 scopus 로고    scopus 로고
    • Autoimmune lymphoproliferative syndrome (ALPS)
    • Bleesing, J. J. 2003. Autoimmune lymphoproliferative syndrome (ALPS). Curr. Pharm. Design. 9:265.
    • (2003) Curr. Pharm. Design. , vol.9 , pp. 265
    • Bleesing, J.J.1
  • 5
    • 0027143640 scopus 로고
    • Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis
    • Bossu, P., Singer, G. G., Andres, P., Ettinger, R., Marshak-Rothstein, A. and Abbas, A. K. 1993. Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J. Immunol. 151:7233.
    • (1993) J. Immunol. , vol.151 , pp. 7233
    • Bossu, P.1    Singer, G.G.2    Andres, P.3    Ettinger, R.4    Marshak-Rothstein, A.5    Abbas, A.K.6
  • 6
    • 0028485743 scopus 로고
    • The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
    • Singer, G. G. and Abbas, A. K. 1994. The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365.
    • (1994) Immunity , vol.1 , pp. 365
    • Singer, G.G.1    Abbas, A.K.2
  • 7
    • 0030175603 scopus 로고    scopus 로고
    • Role of Fas-mediated cell death in the regulation of immune responses
    • Van Parijs, L. and Abbas, A. K. 1996. Role of Fas-mediated cell death in the regulation of immune responses. Curr. Opin. Immunol. 8:355.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 355
    • Van Parijs, L.1    Abbas, A.K.2
  • 10
    • 0018072901 scopus 로고
    • Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
    • Andrews, B. S., Eisenberg, R. A., Theofilopoulos, A. N. et al. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198.
    • (1978) J. Exp. Med. , vol.148 , pp. 1198
    • Andrews, B.S.1    Eisenberg, R.A.2    Theofilopoulos, A.N.3
  • 11
    • 0025875259 scopus 로고
    • Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease
    • Cohen, P. L. and Eisenberg, R. A. 1991. Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 243
    • Cohen, P.L.1    Eisenberg, R.A.2
  • 12
    • 0343938868 scopus 로고    scopus 로고
    • Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype
    • Korner, H., Cretney, E., Wilhelm, P. et al. 2000. Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype. J. Exp. Med. 191:89.
    • (2000) J. Exp. Med. , vol.191 , pp. 89
    • Korner, H.1    Cretney, E.2    Wilhelm, P.3
  • 13
    • 0037005436 scopus 로고    scopus 로고
    • TNFalpha inhibition in MRL/lpr mice ameliorates pulmonary but not renal disease
    • Kim, N., Ussin, L., Cheng, X., Murali, R. and Sullivan, K. E. 2002. TNFalpha inhibition in MRL/lpr mice ameliorates pulmonary but not renal disease. J. Autoimmun. 19:215.
    • (2002) J. Autoimmun. , vol.19 , pp. 215
    • Kim, N.1    Ussin, L.2    Cheng, X.3    Murali, R.4    Sullivan, K.E.5
  • 14
    • 0032518439 scopus 로고    scopus 로고
    • Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice
    • Balomenos, D., Rumold, R. and Theofilopoulos, A. N. 1998. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest. 101:364.
    • (1998) J. Clin. Invest. , vol.101 , pp. 364
    • Balomenos, D.1    Rumold, R.2    Theofilopoulos, A.N.3
  • 15
    • 0030953632 scopus 로고    scopus 로고
    • Roles of interferongamma and interleukin-4 in murine lupus
    • Peng, S. L., Moslehi, J. and Craft, J. 1997. Roles of interferongamma and interleukin-4 in murine lupus. J. Clin. Invest. 99:1936.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1936
    • Peng, S.L.1    Moslehi, J.2    Craft, J.3
  • 16
    • 0031831859 scopus 로고    scopus 로고
    • IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice
    • Schwarting, A., Wada, T., Kinoshita, K., Tesch, G. and Kelley, V. R. 1998. IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice. J. Immunol. 161:494.
    • (1998) J. Immunol. , vol.161 , pp. 494
    • Schwarting, A.1    Wada, T.2    Kinoshita, K.3    Tesch, G.4    Kelley, V.R.5
  • 17
    • 0032607876 scopus 로고    scopus 로고
    • IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family
    • Dinarello, C. A. 1999. IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J. Allergy Clin. Immunol. 103:11.
    • (1999) J. Allergy Clin. Immunol. , vol.103 , pp. 11
    • Dinarello, C.A.1
  • 18
    • 0034268386 scopus 로고    scopus 로고
    • Interleukin-18, a proinflammatory cytokine
    • Dinarello, C. A. 2000. Interleukin-18, a proinflammatory cytokine. Eur. Cytokine Netw. 11:483.
    • (2000) Eur. Cytokine Netw. , vol.11 , pp. 483
    • Dinarello, C.A.1
  • 19
    • 0029880442 scopus 로고    scopus 로고
    • The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLinverted question markMP-lprinverted question marklpr mice
    • Huang, F. P., Feng, G. J., Lindop, G., Stott, D. I. and Liew, F. Y. 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLinverted question markMP-lprinverted question marklpr mice. J. Exp. Med. 183:1447.
    • (1996) J. Exp. Med. , vol.183 , pp. 1447
    • Huang, F.P.1    Feng, G.J.2    Lindop, G.3    Stott, D.I.4    Liew, F.Y.5
  • 20
    • 0031052479 scopus 로고    scopus 로고
    • Up-regulation of tubular epithelial interleukin-12 in autoimmune MRL-Fas(lpr) mice with renal injury
    • Fan, X., Oertli, B. and Wuthrich, R. P. 1997. Up-regulation of tubular epithelial interleukin-12 in autoimmune MRL-Fas(lpr) mice with renal injury. Kidney Int. 51:79.
    • (1997) Kidney Int. , vol.51 , pp. 79
    • Fan, X.1    Oertli, B.2    Wuthrich, R.P.3
  • 21
  • 22
    • 0035874769 scopus 로고    scopus 로고
    • Clear suppression of Th1 responses but marginal amelioration of autoimmune manifestations by IL-12p40 transgene in MRLFAS (lprcg)/FAS(lprcg) mice
    • Yasuda, T., Yoshimoto, T., Tsubura, A. and Matsuzawa, A. 2001. Clear suppression of Th1 responses but marginal amelioration of autoimmune manifestations by IL-12p40 transgene in MRLFAS(lprcg)/FAS(lprcg) mice. Cell. Immunol. 210:77.
    • (2001) Cell. Immunol. , vol.210 , pp. 77
    • Yasuda, T.1    Yoshimoto, T.2    Tsubura, A.3    Matsuzawa, A.4
  • 23
    • 0037378016 scopus 로고    scopus 로고
    • IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology
    • Kikawada, E., Lenda, D. M. and Kelley, V. R. 2003. IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J. Immunol. 170:3915.
    • (2003) J. Immunol. , vol.170 , pp. 3915
    • Kikawada, E.1    Lenda, D.M.2    Kelley, V.R.3
  • 24
    • 0035869307 scopus 로고    scopus 로고
    • Lymphocytes from autoimmune MRL lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chain
    • Neumann, D., Del Giudice, E., Ciaramella, A., Boraschi, D. and Bossu, P. 2001. Lymphocytes from autoimmune MRL lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chain. J. Immunol. 166:3757.
    • (2001) J. Immunol. , vol.166 , pp. 3757
    • Neumann, D.1    Del Giudice, E.2    Ciaramella, A.3    Boraschi, D.4    Bossu, P.5
  • 25
    • 0032400918 scopus 로고    scopus 로고
    • Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis
    • Wildbaum, G., Youssef, S., Grabie, N. and Karin, N. 1998. Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis. J. Immunol. 161:6368.
    • (1998) J. Immunol. , vol.161 , pp. 6368
    • Wildbaum, G.1    Youssef, S.2    Grabie, N.3    Karin, N.4
  • 26
    • 6344279914 scopus 로고    scopus 로고
    • Blockade of IL-18 receptor signaling delays the onset of autoimmune disease in MRL-Faslpr mice
    • Kinoshita, K., Yamagata, T., Nozaki, Y. et al. 2004. Blockade of IL-18 receptor signaling delays the onset of autoimmune disease in MRL-Faslpr mice. J. Immunol. 173:5312.
    • (2004) J. Immunol. , vol.173 , pp. 5312
    • Kinoshita, K.1    Yamagata, T.2    Nozaki, Y.3
  • 27
    • 0033020168 scopus 로고    scopus 로고
    • Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-gamma receptor/IgG1 fusion protein
    • Prud'homme, G. J. and Chang, Y. 1999. Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-gamma receptor/IgG1 fusion protein. Gene Ther. 6:771.
    • (1999) Gene Ther. , vol.6 , pp. 771
    • Prud'homme, G.J.1    Chang, Y.2
  • 28
    • 0037250461 scopus 로고    scopus 로고
    • Immune modulation by plasmid DNA-mediated cytokine gene transfer
    • Piccirillo, C. A. and Prud'homme, G. J. 2003. Immune modulation by plasmid DNA-mediated cytokine gene transfer. Curr. Pharm. Design. 9:83.
    • (2003) Curr. Pharm. Design. , vol.9 , pp. 83
    • Piccirillo, C.A.1    Prud'homme, G.J.2
  • 29
    • 0032490679 scopus 로고    scopus 로고
    • Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition
    • Putterman, C. and Diamond, B. 1998. Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition. J. Exp. Med. 188:29.
    • (1998) J. Exp. Med. , vol.188 , pp. 29
    • Putterman, C.1    Diamond, B.2
  • 30
    • 0025021938 scopus 로고
    • Serological and histological characterization of the new mutant strain of lpr mice, CBA/KlJms-lprcg/lprcg
    • Kimura, M., Mohri, H., Shimada, K., Wakabayashi, T., Kanai, Y. and Matsuzawa, A. 1990. Serological and histological characterization of the new mutant strain of lpr mice, CBA/KlJms-lprcg/lprcg. Clin. Exp. Immunol. 79:123.
    • (1990) Clin. Exp. Immunol. , vol.79 , pp. 123
    • Kimura, M.1    Mohri, H.2    Shimada, K.3    Wakabayashi, T.4    Kanai, Y.5    Matsuzawa, A.6
  • 32
    • 10744222448 scopus 로고    scopus 로고
    • IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease
    • Bossu, P., Neumann, D., Del Giudice, E. et al. 2003. IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease. Proc. Natl Acad. Sci. USA 100:14181.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 14181
    • Bossu, P.1    Neumann, D.2    Del Giudice, E.3
  • 34
    • 0034897403 scopus 로고    scopus 로고
    • Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway
    • Garren, H., Ruiz, P. J., Watkins, T. A. et al. 2001. Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway. Immunity 15:15.
    • (2001) Immunity , vol.15 , pp. 15
    • Garren, H.1    Ruiz, P.J.2    Watkins, T.A.3
  • 35
    • 0041926322 scopus 로고    scopus 로고
    • Molecular and cellular basis for designing gene vaccines against inflammatory autoimmune disease
    • Ghoreschi, K. and Rocken, M. 2003. Molecular and cellular basis for designing gene vaccines against inflammatory autoimmune disease. Trends Mol. Med. 9:331.
    • (2003) Trends Mol. Med. , vol.9 , pp. 331
    • Ghoreschi, K.1    Rocken, M.2
  • 36
    • 18244422120 scopus 로고    scopus 로고
    • IL-12-encoding plasmid has a beneficial effect on spontaneous autoimmune disease in MRL/MP-lpr/lpr mice
    • Hagiwara, E., Okubo, T., Aoki, I. et al. 2000. IL-12-encoding plasmid has a beneficial effect on spontaneous autoimmune disease in MRL/MP-lpr/ lpr mice. Cytokine 12:1035.
    • (2000) Cytokine , vol.12 , pp. 1035
    • Hagiwara, E.1    Okubo, T.2    Aoki, I.3
  • 37
    • 0035253510 scopus 로고    scopus 로고
    • Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination
    • Tisch, R., Wang, B., Weaver, D. J. et al. 2001. Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination. J. Immunol. 166:2122.
    • (2001) J. Immunol. , vol.166 , pp. 2122
    • Tisch, R.1    Wang, B.2    Weaver, D.J.3
  • 38
    • 0036146319 scopus 로고    scopus 로고
    • Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: Addition of IL-4 increases safety
    • Wolfe, T., Bot, A., Hughes, A. et al. 2002. Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: Addition of IL-4 increases safety. Eur. J. Immunol. 32:113.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 113
    • Wolfe, T.1    Bot, A.2    Hughes, A.3
  • 39
    • 0036913169 scopus 로고    scopus 로고
    • Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease
    • Sun, Y., Chen, H. M., Subudhi, S. K. et al. 2002. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat. Med. 8:1405.
    • (2002) Nat. Med. , vol.8 , pp. 1405
    • Sun, Y.1    Chen, H.M.2    Subudhi, S.K.3
  • 40
    • 0035892747 scopus 로고    scopus 로고
    • Role of IL-18 in acute lung inflammation
    • Jordan, J. A., Guo, R. F., Yun, E. C. et al. 2001. Role of IL-18 in acute lung inflammation. J. Immunol. 167:7060.
    • (2001) J. Immunol. , vol.167 , pp. 7060
    • Jordan, J.A.1    Guo, R.F.2    Yun, E.C.3
  • 41
    • 0021173447 scopus 로고
    • Induction of various autoantibodies by mutant gene lpr in several strains of mice
    • Izui, S., Kelley, V. E., Masuda, K., Yoshida, H., Roths, J. B. and Murphy, E. D. 1984. Induction of various autoantibodies by mutant gene lpr in several strains of mice. J. Immunol. 133:227.
    • (1984) J. Immunol. , vol.133 , pp. 227
    • Izui, S.1    Kelley, V.E.2    Masuda, K.3    Yoshida, H.4    Roths, J.B.5    Murphy, E.D.6
  • 42
    • 0035500546 scopus 로고    scopus 로고
    • A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease
    • Esfandiari, E., McInnes, I. B., Lindop, G. et al. 2001. A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease. J. Immunol. 167:5338.
    • (2001) J. Immunol. , vol.167 , pp. 5338
    • Esfandiari, E.1    McInnes, I.B.2    Lindop, G.3
  • 43
    • 33744823535 scopus 로고    scopus 로고
    • Chloroquine treatment influences proinflammatory cytokine levels in systemic lupus erythematosus patients
    • Wozniacka, A., Lesiak, A., Narbutt, J., McCauliffe, D. P. and Sysa-Jedrzejowska, A. 2006. Chloroquine treatment influences proinflammatory cytokine levels in systemic lupus erythematosus patients. Lupus 15:268.
    • (2006) Lupus , vol.15 , pp. 268
    • Wozniacka, A.1    Lesiak, A.2    Narbutt, J.3    McCauliffe, D.P.4    Sysa-Jedrzejowska, A.5
  • 44
    • 3042620058 scopus 로고    scopus 로고
    • Elevated interleukin-18 levels correlated with disease activity in systemic lupus erythematosus
    • Park, M. C., Park, Y. B. and Lee, S. K. 2004. Elevated interleukin-18 levels correlated with disease activity in systemic lupus erythematosus. Clin. Rheumatol. 23:225.
    • (2004) Clin. Rheumatol. , vol.23 , pp. 225
    • Park, M.C.1    Park, Y.B.2    Lee, S.K.3
  • 45
    • 0033786599 scopus 로고    scopus 로고
    • Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosus
    • Wong, C. K., Li, E. K., Ho, C. Y. and Lam, C. W. 2000. Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosus. Rheumatology (Oxford) 39:1078.
    • (2000) Rheumatology (Oxford) , vol.39 , pp. 1078
    • Wong, C.K.1    Li, E.K.2    Ho, C.Y.3    Lam, C.W.4
  • 46
    • 0032927145 scopus 로고    scopus 로고
    • Levels of IL-12 in the sera of patients with systemic lupus erythematosus (SLE)-relation to Th1- and Th2-derived cytokines
    • Tokano, Y., Morimoto, S., Kaneko, H. et al. 1999. Levels of IL-12 in the sera of patients with systemic lupus erythematosus (SLE)-relation to Th1- and Th2-derived cytokines. Clin. Exp. Immunol. 116:169.
    • (1999) Clin. Exp. Immunol. , vol.116 , pp. 169
    • Tokano, Y.1    Morimoto, S.2    Kaneko, H.3
  • 47
    • 0034669914 scopus 로고    scopus 로고
    • A targeted DNA vaccine augments the natural immune response to self TNF-alpha and suppresses ongoing adjuvant arthritis
    • Wildbaum, G., Youssef, S. and Karin, N. 2000. A targeted DNA vaccine augments the natural immune response to self TNF-alpha and suppresses ongoing adjuvant arthritis. J. Immunol. 165:5860.
    • (2000) J. Immunol. , vol.165 , pp. 5860
    • Wildbaum, G.1    Youssef, S.2    Karin, N.3
  • 48
    • 0033846366 scopus 로고    scopus 로고
    • C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis
    • Youssef, S., Maor, G., Wildbaum, G., Grabie, N., Gour-Lavie, A. and Karin, N. 2000. C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis. J. Clin. Invest. 106:361.
    • (2000) J. Clin. Invest. , vol.106 , pp. 361
    • Youssef, S.1    Maor, G.2    Wildbaum, G.3    Grabie, N.4    Gour-Lavie, A.5    Karin, N.6
  • 49
    • 0038376618 scopus 로고    scopus 로고
    • TNFalpha DNA vaccination prevents clinical manifestations of experimental antiphospholipid syndrome
    • Blank, M., Krause, I., Wildbaum, G., Karin, N. and Shoenfeld, Y. 2003. TNFalpha DNA vaccination prevents clinical manifestations of experimental antiphospholipid syndrome. Lupus 12:546.
    • (2003) Lupus , vol.12 , pp. 546
    • Blank, M.1    Krause, I.2    Wildbaum, G.3    Karin, N.4    Shoenfeld, Y.5


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