EphB3 receptor and ligand expression in the adult rat brain

Journal of Molecular Histology

Volumn 37, Issue 8-9, 2006, Pages 369-380

  Willson, Christopher A ^a   Foster, Roy D ^a   Onifer, Stephen M ^a,c   Whittemore, Scott R ^a   Miranda, Jorge D ^b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

EphB3; Ephrin; Immunohistochemistry; In situ hybridization; Plasticity

Indexed keywords

EPHRIN B3; EPHRIN RECEPTOR B3; LIGAND; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENTORHINAL CORTEX; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; LIGAND BINDING; MOTOR CORTEX; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAPHE NUCLEUS; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SENSORY CORTEX;

ANIMALS; BRAIN; FEMALE; LIGANDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPHB3; RNA, MESSENGER;

EID: 33845361273     PISSN: 15672379     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10735-006-9067-0     Document Type: Article

References (78)

1. Asan E, Langenhan T, Holtman B et al (2003) Ciliary neurotrophic factor in the olfactory bulb of rats and mice. Neuroscience 120:99-112
2. Baker RK, Vanderboom AK, Bell GW et al (2001) Expression of the receptor tyrosine kinase gene EphB3 during early stages of chick embryo development. Mech Develop 104:129-132
3. Ben-Ari Y, Represa A, Tremblay E et al (1992) Epileptogenesis and neuronal plasticity: studies on kainate receptor in the human and rat hippocampus. Epilepsy Res Suppl 8:369-373
4. Benson MD, Romero MI, Lush ME et al (2005) Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. PNAS 102:10694-10699
5. Bergemann AD, Cheng HG, Brambilla R et al (1995) ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol Cell Biol 15:4921-4929
6. Biervert C, Horvath E, Fahrig T (2001) Semiquantitative expression analysis of ephrine-receptor tyrosine kinase mRNA's in a rat model of traumatic brain injury. Neurosci Letts 315:25-28
7. Braisted JE, McLaughlin T, Wang HU et al (1997) Graded and lamina-specific distributions of ligands of EphB receptor tyrosine kinases in the developing retinotectal system. Develop Biol 191:14-28
8. Breitschopf H, Suchanek G, Gould RM et al (1992) In situ hybridization with digoxigenin-labeled probes: sensitive and reliable detection method applied to myelinating rat brain. Acta Neuropathol 84(6):581-587
9. Bruckner K, Pasquale EB, Klein R (1997) Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science 275:1640-1643
10. Bundesen LQ, Scheel TA, Bregman BS et al (2003). Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats. J Neurosci 23:7789-7800
11. Calo L, Cinque C, Patane M et al (2006) Interaction between ephrins/Eph receptors and excitatory amino acid receptors. J Neurochem 98:1-10
12. Carpenter MK, Shilling H, Vandenbos T et al (1995) Ligands for EPH-related tyrosine kinase receptors are developmentally regulated in the CNS. J Neurosci Res 42:199-206
13. Castellani V, Yue Y, Gao P et al (1998) Dual action of a ligand for Eph receptor tyrosine kinases on specific populations of axons during the development of cortical circuits. J Neurosci 18:4663-4672
14. Cheng HJ, Flanagan JG (1994) Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell 79:157-168
15. Cheng HJ, Nakamoto M, Bergemann AD et al (1995) Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell 82:371-381
16. Cheung CC, Hohmann JG, Clifton DK et al (2001) Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus. Neuroscience 103:423-432
17. Ciossek T, Lerch MM, Ullrich A (1995) Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family. Oncogene 11:2085-2095
18. Conover JC, Doetsch F, Garcia-Verdugo JM et al (2000) Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone. Nat Neurosci 3:1091-1097
19. Davy A, Gale NW, Murray EW et al (1999) Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Develop 13:3125-3135
20. Drescher U, Kremoser C, Handwerker C et al (1995) In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell 82:359-370
21. Eph Nomenclature Committee (1997) Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell 90:403-404
22. Flanagan JG, Vanderhaeghen P (1998) The ephrins and Eph receptors in neural development. Annl Rev Neurosci 21:309-345
23. Flenniken AM, Gale NW, Yancopoulos GD et al (1996) Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis. Develop Biol 179:382-401
24. Friesen J, Barbacid M (1997) Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system. Cell Tissue Res 290:209-215
25. Gale NW, Flenniken A, Compton DC et al (1996a) Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. Oncogene 13:1343-1352
26. Gale NW, Holland SJ, Valenzuela DM et al (1996b) Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron 17:9-19
27. Gao PP, Yue Y, Cerretti DP et al (1999) Ephrin-dependent growth and pruning of hippocampal axons. Proc Natl Acad Sci USA 96:4073-4077
28. Gao PP, Zhang JH, Yokoyama M et al (1996) Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal system. Proc Natl Acad Sci USA 93:11161-11166
29. Gao WQ, Shinsky N, Armanini MP et al (1998) Regulation of hippocampal synaptic plasticity by the tyrosine kinase receptor, REK7/EphA5, and its ligand, AL-1/Ephrin-A5. Mol Cell Neurosci 11:247-259
30. Gerlai R, Shinsky N, Shih A et al (1999) Regulation of learning by EphA receptors: a protein targeting study. J Neurosci 19:9538-9549
31. Goldshmit Y, Galea MP, Wise G et al (2004) Axonal regeneration and lack of astrocytic gliosis in EphA4 deficient mice. J Neurosci 24:10064-10073
32. Grunwald IC, Korte M, Wolfer D et al (2001) Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron 32:1027-1040
33. Henderson JT, Georgiou J, Jia Z et al (2001) The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron 32:1041-1056
34. Henkemeyer M, Itkis OS, Ngo M et al (2003) Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol 163:1313-1326
35. Henkemeyer M, Marengere LE, McGlade J et al (1994) Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene 9:1001-1014
36. Holland SJ, Gale NW, Mbamalu G et al (1996) Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature 383:722-725
37. Holmberg J, Clarke DL, Frisen J (2000) Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Nature 408:203-206
38. Holmberg J, Frisen J (2002) Ephrins are not only unattractive. Trends Neurosci 25:239-243
39. Humpel C, Lindqvist E, Olson L (1993) Detection of nerve growth factor mRNA in rodent salivary glands with digoxigenin-and 33P-labeled oligonucleotides: effects of castration and sympathectomy. J Histochem Cytochem 41:703-708
40. Irizarry-Ramírez M, Willson CA, Cruz L et al (2005) Upregulation of EphA3 receptors after spinal cord injury. J Neurotrauma 22:929-935
41. Jevince AR, Kadison SR, Pittman AJ et al (2006) Distribution of EphB receptors and Ephrin-B1 in the developing vertebrate spinal cord. J of Comparative Neurology 497:734-750
42. Kempermann G, Kuhn HG, Cage FH (1997) More hippocampal neurons in adult mice living in an enriched environment. Nature 386:493-495
43. Keynes R, Cook GM (1995) Axon guidance molecules. Cell 83:161-169
44. Komminoth P, Merk FB, Leav I et al (1992) Comparison of 35S-and digoxigenin-labeled RNA and oligonucleotide probes for in situ hybridization. Expression of mRNA of the seminal vesicle secretion protein II and androgen receptor genes in the rat prostate. Histochemistry 98:217-228
45. Kullander K, Butt SJ, Lebret JM et al (2003) Role of EphA4 and EphrinB3 in local neuronal circuits that control walking. Science 299:1889-1892
46. Kullander K, Klein R (2002) Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol 3:475-486
47. Lai C, Lemke G (1991) An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron 6:691-704
48. Liebl D, Morris D, Henkemeyer M et al (2003) mRNA Expression of ephrins and Eph receptor tyrosine kinases in the neonatal and adult mouse central nervous system. J Neurosci Res 71:7-22
49. Liu X, Hawkes E, Ishimaru T et al (2006) EphB3: An endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci 26:3087-3101
50. Marquardt T, Shirasaki R, Ghosh S et al (2005) Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell 121:4-6
51. Martone ME, Holash JA, Bayardo A et al (1997) Immunolocalization of the receptor tyrosine kinase EphA4 in the adult rat central nervous system. Brain Res 771:238-250
52. Mellitzer G, Xu G, Wilkinson DG (1999) Eph receptors and ephrins restrict cell intermingling and communication. Nature 400:77-81
53. Miranda JD, White LA, Marcillo AE et al (1999) Induction of Eph B3 after spinal cord injury. Exp Neurol 156:218-222
54. Moreno-Flores MT, Wandosell F (1999) Upregulation of Eph receptors after excitotoxic injury in adult hippocampus. Neuroscience 91:193-201
55. Mori T, Wanaka A, Taguchi A et al (1995) Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Brain Res Mol Brain Res 29:325-335
56. Murai KK, Pasquale EB (2004) Eph receptors, ephrins and synaptic function. Neurosci 10:304-314
57. O'Leary DD, Wilkinson DG (1999) Eph receptors and ephrins in neural development. Curr Opin Neurobiol 9:65-73
58. Orioli D, Henkemeyer M, Lemke G et al (1996) Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J 15:6035-6049
59. Orioli D, Klein R (1997) The Eph receptor family: axonal guidance by contact repulsion. Trends Genet 13:354-359
60. Pasquale EB (1997) The Eph family of receptors. Curr Opin Cell Biol 9:608-615
61. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic Press, San Diego
62. Puente XS, Lopez-Otin C (2004) A genomic analysis of rat proteases and protease inhibitors. Genome Res 14:609-622
63. Ricard J, Salinas J, Garcia L et al (2006) EphrinB3 regulates cell proliferation and survival in adult neurogenesis. Mol Cell Neurosci 31:713-722
64. Rodenas-Ruano A, Perez-Pinzon MA, Green EJ et al (2006) Distinct roles for ephrinB3 in the formation and function of hippocampal synapses. Dev Biol 292:34-45
65. Rogers JH, Ciossek T, Menzel P et al (1999) Eph receptors and ephrins demarcate cerebellar lobules before and during their formation. Mech Develop 87:119-128
66. Schaeren-Wiemers N, Gerfin-Moser A (1993) A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 100:43-440
67. Sobel RA (2005) EphrinA receptors and ligands in lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol 15:35-45
68. Stein E, Savaskan NE, Ninnemann O et al (1999) A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. J Neurosci 19:8885-8893
69. Takasu MA, Dalva MB, Zigmond RE et al (2002) Modulation of NMDA receptor-dependent calcium influx and gene expresion through EphB receptors. Science 295:491-495
70. Tessier-Lavigne M, Goodman CS (1996) The molecular biology of axon guidance. Science 274:1123-1133
71. Wang HU, Anderson DJ (1997) Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron 18:383-396
72. Wilkinson DG (2001) Multiple roles of Eph receptors and ephrins in neural development. Nat Rev Neurosci 2:155-164
73. Willson CA, Irizarry-Ramírez M, Gaskins HE et al (2002) Upregulation of EphA receptor expression in the injured adult spinal cord. Cell Transplant 11:229-239
74. Willson CA, Miranda JD, Foster RD et al (2003) Transection of the adult rat spinal cord upregulates EphB3 receptor and ligand expression. Cell Transplant 12:279-290
75. Yue Y, Widmer DA, Halladay AK et al (1999) Specification of distinct dopaminergic neural pathways: roles of the Eph family receptor EphB1 and ligand ephrin-B2. J Neurosci 19:2090-2101
76. Zagrebelsky M, Buffo A, Skerra A et al (1998) Retrograde regulation of growth-associated gene expression in adult rat Purkinje cells by myelin-associated neurite growth inhibitory proteins. J Neurosci 18:7912-7929
77. Zhang JH, Cerretti DP, Yu T et al (1996) Detection of ligands in regions anatomically connected to neurons expressing the Eph receptor Bsk: potential roles in neuron-target interaction. J Neurosci 16:7182-7192
78. Zisch AH, Pasquale EB (1997) The Eph family: a multitude of receptors that mediate cell recognition signals. Cell Tissue Res 290:217-226