Reduction of C-reactive protein by a single 80 mg of simvastatin in patients with unstable angina

Clinica Chimica Acta

Volumn 376, Issue 1-2, 2007, Pages 163-167

  Li, Jian Jun ^a   Wang, Ying ^b   Nie, Shao Ping ^c   Zhang, Chao Yang ^a   Li, Yi Shi ^a   Hui, Ru Tai ^a   Zhen, Xin ^a  

^a FUWAI HOSPITAL   (China)

^b THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

C reactive protein; Lipid profile; Simvastatin; Unstable angina

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; NITRATE; PLACEBO; SIMVASTATIN;

ADULT; ARTICLE; BLOOD SAMPLING; CARDIAC PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; HIGH RISK POPULATION; HOSPITAL ADMISSION; HUMAN; INFLAMMATION; MALE; MEASUREMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SINGLE DRUG DOSE; THORAX PAIN; UNSTABLE ANGINA PECTORIS; VASCULAR ENDOTHELIUM;

ANGINA, UNSTABLE; C-REACTIVE PROTEIN; DOWN-REGULATION; FEMALE; HUMANS; MALE; MIDDLE AGED; SIMVASTATIN; TREATMENT OUTCOME;

ANGINA;

EID: 33845331394     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2006.08.012     Document Type: Article

References (19)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 340 (1999) 115-126
2. Maseri A. Inflammation, atherosclerosis, and ischemic events: exploring the hidden side of the noon. N Engl J Med 336 (1997) 1014-1016
3. Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 103 (2001) 1813-1818
4. Ferranti S.D., and Rifai N. C-reactive protein and cardiovascular disease: a review of risk prediction and interventions. Clin Chim Acta 317 (2002) 1-15
5. Li J.-J., Jiang H., Huang C.-X., et al. Increased concentrations of plasma C-reactive protein in patients with unstable angina: its relations with coronary stenosis and lipid profile. Angiology 53 (2002) 265-272
6. Jackson G. The role of statins in acute coronary syndromes: managing the unmet need. Int J Clin Pract 54 (2000) 445-449
7. Fairhurst K., and Huby G. From trial data to practical knowledge: qualitative study of how general practitioners have accessed and used evidence about statin drugs in their management of hypercholesterolaemia. BMJ 317 (1998) 1130-1134
8. Azar R.R., Waters D.D., and Lebanon B. PRINCE's prospects: statin, inflammation, and coronary risk. Am Heart J 141 (2001) 881-883
9. Li J.-J., Chen M.-Z., Chen X., et al. Rapid effects of simvastatin on lipid profile and C-reactive protein in patients with hypercholesterolemia. Clin Cardiol 26 (2003) 472-476
10. Li J.-J., and Chen X.-J. Simvastatin inhibits interleukin-6 release in human monocytes stimulated by C-reactive protein and lipopolysaccharide. Coron Artery Dis 14 (2003) 329-334
11. Treasure C.B., Klein J.L., Weintraub W.S., et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 332 (1995) 481-487
12. Ridker P.M., Rifai N., and Lowenthal S.P. Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia. Circulation 103 (2001) 1191-1193
13. Plenge J.K., Hernandez T.L., Weil K.M., et al. Simvastatin lowers C-reactive protein within 14 days: an effect independent of low-density lipoprotein cholesterol reduction. Circulation 106 (2002) 1447-1452
14. Gensini C.G. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 151 (1983) 606-610
15. Meier-Ewert H.K., Ridlker P.M., Rifai N., Price N., Dinges D.F., and Mullington J.M. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects. Clin Chem 47 (2001) 426-430
16. Ockene I.S., Matthews C.E., Rifai N., Ridker P.M., Reed G., and Stanek E. Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults. Clin Chem 47 (2001) 444-450
17. Heeschen C., Hamm C.W., Laufs U., et al. Withdrawal of statins increases event rates in patients with acute coronary syndromes. Circulation 105 (2002) 1446-1452
18. Ridker P.M., Rifai N., Pfeffer M.A., Sacks F., and Manson J.E. Long-term effects of pravastatin on plasma concentration of C-reactive protein. Circulation 100 (1999) 230-235
19. Ostadal P., Alan D., Hajek P., et al. The effect of early treatment by cerivastatin on the serum concentration of C-reactive protein, interleukin-6, and interleukin-8 in the patients with unstable angina and non-Q-wave myocardial infarction. Mol Cell Biochem 246 (2003) 45-50