Magnesium for neuroprotection after traumatic brain injury

Lancet Neurology

Volumn 6, Issue 1, 2007, Pages 20-21

  Maas, Andrew IR ^a   Murray, Gordon D ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM; PLACEBO;

CLINICAL PRACTICE; CLINICAL TRIAL; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG FATALITY; DRUG MEGADOSE; GLASGOW COMA SCALE; HIPPOCAMPUS; HUMAN; LETTER; MORTALITY; NEUROPROTECTION; OUTCOMES RESEARCH; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY;

BRAIN CHEMISTRY; BRAIN INJURIES; GLASGOW COMA SCALE; HUMANS; MAGNESIUM; MAGNESIUM SULFATE; NEUROPROTECTIVE AGENTS; TREATMENT OUTCOME;

EID: 33845325803     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(06)70668-8     Document Type: Letter

References (9)

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2. Heath D., and Vink R. Optimization of magnesium therapy after severe diffuse axonal brain injury in rats. J Pharmacol Exp Ther 288 (1996) 1311-1316
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4. Memon Z., Altura B., Benjamin J., et al. Predictive value of serum ionized but not total magnesium levels in head injuries. Scand J Clin Lab Invest 55 (1995) 671-677
5. Hoane M., Barbay S., and Barth T. Large cortical lesions produce enduring forelimb placing deficits in un-treated rats and treatment with NMDA antagonists or anti-oxidant drugs induces behavioral recovery. Brain Res Bull 53 (2000) 175-186
6. Bareyre F., Saatman K., Raghupathi R., et al. Postinjury treatment with magnesium chloride attenuates cortical damage after traumatic brain injury in rats. J Neurotrauma 17 (2000) 1029-1039
7. Enomoto T., Osugi T., Satoh H., et al. Pre-injury magnesium treatment prevents traumatic brain injury-induced hippocampal ERK activation, neuronal loss, and cognitive dysfunction in the radial-arm maze test. J Neurotrauma 22 (2005) 783-792
8. Maas AIR, Marmarou A, Murray GD, et al. Prognosis and clinical trial design in traumatic brain injury: the IMPACT study. J Neurotrauma (in press).
9. Murray G., Barer D., Choi S., et al. Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy. J Neurotrauma 22 (2005) 511-517