Protective effects of tanshinone II A on ethanol-induced neurotoxicity in PC12 cells

Chinese Pharmaceutical Journal

Volumn 41, Issue 20, 2006, Pages 1553-1556

  Zou, Xiao Jing ^a   Meng, Xian Fang ^a   Yao, Shang Long ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Ethanol; p53 protein; PC12; Tanshinone II A

Indexed keywords

[3 (4,5 DIMETHYLTHIAZOL 2 YL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE]; ALCOHOL; BROMINE DERIVATIVE; LACTATE DEHYDROGENASE; PROTEIN P53; TANSHINONE; TANSHINONE II A; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; IN VITRO STUDY; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION;

EID: 33845254588     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. CREWS F T, BRAUN C J, HOPLIGHT B, et al. Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats[J]. Alcohol Clin Exp Res, 2000, 24(11):1712-1723.
2. RUPP C I, KURZ M, KEMMLER G, et al. Reduced olfactory sensitivity, discrimination, and identification in patients with alcohol dependence[J]. Alcohol Clin Exp Res, 2003, 27(3):432-439.
3. NIU X L, ICHIMORI K, YANG X, et al. Tanshinone IIA inhibits low density lipoprotein oxidation in vitro[J] . Free Radic Res, 2000, 33 (3):305-312.
4. LI Y X, KING M A, GRIMES J, et al. Alpha7 nicotinic receptor mediated protection against ethanol-induced cytotoxicity in PC12 cells[J]. Brain Research, 1999, 816(1):225-228.
5. YOUNG C, KLOCKE B J, TENKOVA T. Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain[J]. Cell Death Differ, 2003, 10(10):1148-1155.
6. NOWOSLAWSKI L, KLOCKEl B J, ROTH K A, et al. Molecular regulation of acute ethanol-induced neuron apoptosis[J]. J Neuropathol Exp Neurol, 2005, 64(6):490-497.
7. BAILEY S M, PATEL V B, YOUNG T A, et al. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver[J]. Alcohol Clin Exp Res, 2001, 25 (5):726-733.
8. HONG C Y, HUANG S C, LIN S K, et al. Noreantharidin-induced post-G(2)/M apoptosis is dependent on wild-type p53 gene[J] . Biochem Biophys Res Commun, 2000, 276(1):278-285.
9. JANKLA H, ERIKSSON P C J, EKLUND K. Effect of chronic ethanol ingestion and gender on heart left ventricular p53 gene expression[J]. Alcohol Clin Exp Res, 2005, 29(8):1368-1373.
10. HOFSETH L J, HUSSAIN S P, HARRIS C C. P53:25 years after its discovery[J]. Trends Pharmacol Sci, 2004, 25(4):177-181.
11. MARTIN L J, PRICE A C, MCCLENDON K B, et al. Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo : oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins[J]. J Neurochem, 2003, 85(1):234-247.