TSH-dependent expression of the LDL Receptor-Associated Protein (RAP) in thyroid epithelial cells

Thyroid

Volumn 16, Issue 11, 2006, Pages 1097-1104

  Botta, Roberta ^a   Lisi, Simonetta ^a   Pinchera, Aldo ^a   Segnani, Cristina ^a   Cianferotti, Luisella ^a   Altea, Maria Antonietta ^a   Menconi, Francesca ^a   Mattii, Letizia ^a   Corsini, Giovanni Umberto ^a   Marcocci, Claudio ^a   Dolfi, Amelio ^a   Bernardini, Nunzia ^a   Marinò, Michele ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; THYROGLOBULIN; THYROTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYPOTHYROIDISM; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID CELL; THYROID HORMONE RELEASE; WESTERN BLOTTING;

ANIMALS; ANTITHYROID AGENTS; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; COS CELLS; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYPOTHYROIDISM; LDL-RECEPTOR RELATED PROTEIN-ASSOCIATED PROTEIN; METHIMAZOLE; MICE; PERCHLORIC ACID; RATS; SODIUM COMPOUNDS; THYROID GLAND; THYROTROPIN; UP-REGULATION;

EID: 33845253186     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.2006.16.1097     Document Type: Article

References (22)

1. Bu G 2001 The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family. Int Rev Cytol 209:79-116.
2. Willnow TE 1998 Receptor-associated protein (RAP): a specialized chaperone for endocytic receptors. Biol Chem 379:1025-1031.
3. Marinò M, Zheng G, Chiovato L, Pinchera A, Brown D, Andrews D, McCluskey RT 2000 Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells: a novel function in the control of thyroid hormone release. J Biol Chem 275:7125-7138.
4. Lisi S, Pinchera A, McCluskey RT, Willnow TE, Refetoff S, Marcocci C, Vitti P, Menconi F, Grasso L, Luchetti F, Collins AB, Marinò M 2003 Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release. Proc Natl Acad Sci USA 100:14858-14863.
5. Lisi S, Botta R, Pinchera A, Collins AB, Refetoff S, Arvan P, Bu G, Grasso L, Marshansky V, Bechoua S, Hurtado-Lorenzo S, Marcocci C, Brown D, McCluskey RT, Marinò M 2006 Defective thyroglobulin (Tg) storage in LDL receptor associated protein (RAP) deficient mice. Am J Physiol Cell Physiol 290:C1160-C1167.
6. Marinò M, Chiovato L, Lisi S, Pinchera A, McCluskey RT 2001 Binding of the low density lipoprotein receptor-associated protein (RAP) to thyroglobulin (Tg): putative role of RAP in the Tg secretory pathway. Mol Endocrinol 15:1829-1837.
7. Lisi S, Chiovato L, Pinchera A, Marcocci C, Menconi F, Morabito E, Altea MA, McCluskey RT, Marinò M 2003 Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway. J Endocrinol Invest 26:1105-1106.
8. Zheng G, Marinò M, Zhao J, McCluskey RT 1998 Megalin (gp330): a putative endocytic receptor for thyroglobulin (Tg). Endocrinology 139:1462-1465.
9. Marinò M, Zheng G, McCluskey RT 1999 Megalin (gp330) is an endocyticreceptor for thyroglobulin on cultured thyroid cells (FRTL-5 cells). J Biol Chem 274:12898-12904.
10. Spaulding SW 2005 Biological actions of thyrotropin. In: Braverman LE, Utiger RD (eds) Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text. Lippincott, Williams and Wilkins, Philadelphia, pp 183-197.
11. Zheng G, Bachinsky DR, Stamenkovic I, Strickland DK, Brown D, Andres G, McCluskey RT 1994 Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/a2MR, and the receptor-associated protein (RAP). J Histochem Cytochem 42:531-542.
12. Ambesi-Impiombato FS, Parks LA, Coon HG. 1980. Culture of hormone-dependent functional epithelial cells from rat thyroids. Proc Natl Acad Sci USA 77:3455-3459.
13. Bu G, Rennke S 1996 Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. J Biol Chem 271:22218-22224.
14. Chiovato L, Vitti P, Lombardi A, Lopez G, Santini F, Macchia E, Fenzi GF, Mammoli C, Battiato S, Pinchera A 1987 Detection and characterization of autoantibodies blocking the TSH-dependent cAMP production using FRTL-5 cells. J Endocrinol Invest 10:383-388.
15. Modric T, Rajkumar K, Murphy LJ 1999 Thyroid gland function and growth inIGF binding protein-1 transgenic mice. Eur J Endocrinol 141:149-159.
16. Pohlenz J, Weiss RE, Cua K, Van Sande J, Refetoff S 1999 Improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone. Thyroid 9:1265-1271.
17. Bernardini N, Bianchi F, Dolfi A 1999 Laminin and beta1 integrin distribution in the early stages of human kidney development. Nephron 81:289-295.
18. Muresan Z, Arvan P 1998 Enhanced binding to the molecular chaperone BiP slows thyroglobulin export from the endoplasmic reticulum. Mol Endocrinol 12:458-467.
19. Wadsworth HL, Chazenbalk GD, Rapoport B 1990 Thyrotropin can increase the steady state level of a messenger ribonucleic acid species (glyceraldehyde-3- phosphate dehydrogenase) in thyroid cells by decreasing its rate of disappearance. Endocrinology 127:5-9.
20. Baloch ZA, Livolsi VA 2005 Pathology. In: Braverman LE, Utiger RD (eds) Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text. Lippincott, Williams and Wilkins, Philadelphia, pp 422-449.
21. Takasu N, Oshiro C, Akamine H, Komiya I, Nagata A, Sato Y, Yoshimura H, Ito K 1997 Thyroid-stimulating antibody and TSH-binding inhibitor immunoglobulin in 277 Graves' patients and in 686 normal subjects. J Endocrinol Invest 20:452-461.
22. Tonacchera M, Vitti P, De Servi M, Agretti P, De Marco G, Chiovato L, Pinchera A 2003 Gain of function TSH receptor mutations and iodine deficiency: Implications in iodine prophylaxis. J Endocrinol Invest 26 (Suppl. 2):2-6.