Aquatic toxicity and abiotic thiol reactivity of aliphatic isothiocyanates: Effects of alkyl-size and -shape

Environmental Toxicology and Pharmacology

Volumn 23, Issue 1, 2007, Pages 10-17

  Schultz, T Wayne ^a   Yarbrough, Jason W ^a   Pilkington, Tyler B ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Aquatic toxicity; Isothiocyanates; Structure activity relationship; Tetrahymena pyriformis; Thiol reactivity

Indexed keywords

HYDROCARBON; ISOTHIOCYANIC ACID DERIVATIVE; THIOL GROUP;

AQUATIC ENVIRONMENT; ARTICLE; BINDING SITE; BIOASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; TETRAHYMENA PYRIFORMIS; TOXICITY TESTING; WATER POLLUTION;

TETRAHYMENA PYRIFORMIS;

EID: 33845208182     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2006.05.005     Document Type: Article

References (15)

1. Escher B.I., and Hermens J.L.M. Modes of action in ecotoxicology: their role in body burden, species sensitivity, QSARs, and mixture effects. Environ. Sci. Technol. 36 (2002) 4201-4217
2. Hansch C., Gao H., and Hoekman D. A general approach to comparative QSAR. In: Devillers J. (Ed). Comparative QSAR (1998), Taylor & Francis, Washington, DC 285-368
3. Hermens J.L.M. Electrophiles and acute toxicity to fish. Environ. Health Perspect. 87 (1990) 219-225
4. Könemann H. Quantitative structure-activity relationships in fish toxicity studies. Part 1. Relationship for 50 industrial pollutants. Toxicology 19 (1981) 209-221
5. March J. Advanced Organic Chemistry Reactions, Mechanisms and Structure. 4th ed. (1992), John Wiley & Sons, NY p. 1495
6. Mukerjee A.K., and Ashare R. Isothiocyanates in the chemistry of heterocycles. Chem. Rev. 91 (1991) 1-24
7. Schultz T.W. TETRATOX: Tetrahymena pyriformis population growth impairment endpoint-A surrogate for fish lethality. Toxicol. Meth. 7 (1997) 289-309
8. Schultz T.W., and Comeaux J.L. Structure-toxicity relationships for aliphatic isothiocyanates to Tetrahymena pyriformis. Bull. Environ. Contam. Toxicol. 56 (1996) 638-642
9. Schultz T.W., Cronin M.T.D., Netzeva T.I., and Aptula A.O. Structure-toxicity relationships for aliphatic chemicals evaluated with Tetrahymena pyriformis. Chem. Res. Toxicol. 15 (2002) 1602-1609
10. Schultz T.W., Netzeva T.I., Roberts D.W., and Cronin M.T.D. Structure-toxicity relationships for carbonyl-containing α,β-unsaturated aliphatic chemicals evaluated with Tetrahymena pyriformis. Chem. Res. Toxicol. 18 (2005) 330-341
11. Schultz T.W., Seward-Nagel J., Foster K.A., and Tucker V.A. Structure-activity relationships for aliphatic alcohols and aquatic toxicity to Tetrahymena. Environ. Toxicol. 9 (2004) 1-10
12. Schultz T.W., Yarbrough J.W., and Johnson E.L. Structure-activity relationships for glutathione reactivity of carbonyl-containing compounds. SAR QSAR Environ. Res. 16 (2005) 313-322
13. Thornally P.J. Isothiocyanates: mechanism of cancer chemopreventive action. Anti-cancer Drugs 13 (2002) 331-338
14. Torchinsky Y.M. Surfur in Proteins. 1st ed. (1981), Pergamon Press, Oxford, UK p. 294
15. Veith G.D., Call D.J., and Brooke L.T. Structure-toxicity relationships for the fathead minnow: Pimephelas promelas: narcotic industrial chemicals. Can. J. Fish. Aquat. Sci. 40 (1983) 743-748