Unraveling the aflatoxin-FAPY conundrum: Structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1

Journal of the American Chemical Society

Volumn 128, Issue 47, 2006, Pages 15188-15199

  Brown, Kyle L ^a   Deng, James Z ^a,b   Iyer, Rajkumar S ^a,c   Iyer, Lalitha G ^a,c   Voehler, Markus W ^a   Stone, Michael P ^a   Harris, Constance M ^a   Harris, Thomas M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Gen Probe Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; DNA; EPOXY RESINS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ISOMERIZATION; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE;

AFLATOXIN B (AFB); CONFORMATIONAL ISOMERS; DEOXYNUCLEOSIDES; FORMAMIDOPYRIMIDINE (FAPY);

AMINES;

AFLATOXIN; AFLATOXIN B1; DEOXYNUCLEOSIDE 3',3' DIBUTYRATE; FORMAMIDE DERIVATIVE; FORMAMIDOPYRIMIDINE; FORMIC ACID; GUANINE; OLIGODEOXYNUCLEOTIDE; PYRIMIDINE DERIVATIVE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; DERIVATIZATION; DIASTEREOISOMER; DNA ADDUCT; DNA REPLICATION; HYDROLYSIS; ISOMER; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; PROTEIN PROCESSING; PROTEIN STRUCTURE;

AFLATOXIN B1; DNA ADDUCTS; DNA DAMAGE; DNA REPLICATION; ISOMERISM; KINETICS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; PYRIMIDINES;

EID: 33845200821     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja063781y     Document Type: Article

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