Impact of density gradients on flow-through dissolution in a cylindrical flow cell

Pharmaceutical Development and Technology

Volumn 11, Issue 4, 2006, Pages 529-534

  Stevens, Larry E ^a   Missel, Paul J ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

Density gradient; Dissolution; Drug release; Flow cell orientation; Flow rate; Flow through release; High pressure liquid chromatography (HPLC); Solubility

Indexed keywords

ANECORTAVE; BENZOCAINE; POLYPROPYLENE;

ARTICLE; DENSITY GRADIENT; DIFFUSION; DISSOLUTION; DRUG SOLUBILITY; FINITE ELEMENT ANALYSIS; FLOW RATE; GRAVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SIMULATION;

DIFFUSION; DRUG INDUSTRY; FINITE ELEMENT ANALYSIS; PHARMACOKINETICS; SOLUBILITY;

EID: 33845200185     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450600970441     Document Type: Article

References (7)

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3. Shah, A.C.; Nelson, K.G. Evaluation of a convective diffusion drug dissolution rate model, J. Pharm. Sci. 1975 64, 1518-1520.
4. Missel, P.J.; Stevens, L.E.; Mauger, J.W. Re-examination of convective diffusion/drug dissolution in a laminar flow channel: accurate prediction of dissolution rate, Pharm. Res 2004 21, 2300-2306.
5. USP 28 section 〈724〉 Drug Release, pp. 2415-2417.
6. The Anecortave Acetate Clinical Study Group. Anecortave acetate as monotherapy for treatment of subfoveal neovascularization in age-related macular degeneration (AMD): 12 month clinical outcomes. Ophthalmology 2003, 110, (12), 90-101.
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