Two toxins from Conus striatus that individually induce tetanic paralysis

Biochemistry

Volumn 45, Issue 47, 2006, Pages 14212-14222

  Kelley, Wayne P ^a,c   Schulz, Joseph R ^b,d   Jakubowski, Jennifer A ^a   Gilly, William F ^b   Sweedler, Jonathan V ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b STANFORD UNIVERSITY   (United States)

^c GLAXOSMITHKLINE   (United States)

^d OCCIDENTAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; DNA; IONIZATION; MASS SPECTROMETRY; NANOTECHNOLOGY; PROTEINS;

NANOELECTROSPRAY TECHNIQUES; PUTATIVE PEPTIDES; SPASTIC PARALYSIS; TETANIC PARALYSIS;

TOXIC MATERIALS;

AMINO ACID; CONOTOXIN; CONOTOXIN S4A; PEPTIDE; SNAIL VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CONUS STRIATUS; ELECTROSPRAY IONIZATION ION TRAP MASS SPECTROMETRY; ELECTROSPRAY MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MUSCLE CELL; MUSCLE TETANIC CONTRACTION; NANOELECTROSPRAY MASS SPECTROMETRY; NERVE FIBER; NEUROMUSCULAR SYNAPSE; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; PROTEIN PROCESSING; SEQUENCE ANALYSIS; SNAIL; STRUCTURE ANALYSIS; TETANIC PARALYSIS; TETANY; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONOTOXINS; CONUS SNAIL; DNA, COMPLEMENTARY; GLYCOSYLATION; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PARALYSIS; TETANY;

ANURA; CONUS STRIATUS; GASTROPODA;

EID: 33751583983     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061485s     Document Type: Article

References (43)

1. Craig, A. G., Bandyopadhyay, P., and Olivera, B. M. (1999) Post-translationally modified neuropeptides from Conus venoms, Eur. J. Biochem. 264, 271-275.
2. Jakubowski, J. A., Kelley, W. P., and Sweedler, J. V. (2006) Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery, Toxicon 47, 688-699.
3. McIntosh, J. M., Olivera, B. M., and Cruz, L. J. (1999) Conus peptides as probes for ion channels, Methods Enzymol. 294, 605-624.
4. Duda, T. F., Kohn, A. J., and Palumbi, S. R. (2001) Origins of diverse feeding ecologies within Conus, a genus of venomous marine gastropods, Biol. J. Linn. Soc. 73, 391-409.
5. Jones, R. M., and Bulaj, G. (2000) Conotoxins - new vistas for peptide therapeutics, Curr. Pharm. Des. 6, 1249-1285.
6. Terlau, H., and Olivera, B. M. (2004) Conus venoms: a rich source of novel ion channel-targeted peptides, Physiol. Rev. 84, 41-68.
7. Layer, R. T., and McIntosh, J. M. (2006) Conotoxins: therapeutic potential and applications, Marine Drugs 4, 119-142.
8. Livett, B. G., Gayler, K. R., and Khalil, Z. (2004) Drugs from the sea: conopeptides as potential therapeutics, Curr. Med. Chem. 11, 1715-1723.
9. +-dependent mechanism, Eur. J. Neurosci. 11, 3134-3142.
10. Le Gall, F., Favreau, P., Richard, G., Letourneux, Y., and Molgo, J. (1999) The strategy used by some piscivorous cone snails to capture their prey: the effects of their venoms on vertebrates and on isolated neuromuscular preparations, Toxicon 37, 985-998.
11. Craig, A. G., Zafaralla, G., Cruz, L. J., Santos, A. D., Hillyard, D. R., Dykert, J., Rivier, J. E., Gray, W. R., Imperial, J., Delacruz, R. G., Sporning, A., Terlau, H., West, P. J., Yoshikami, D., and Olivera, B. M. (1998) An O-glycosylated neuroexcitatory Conus peptide, Biochemistry 37, 16019-16025.
12. Walker, C. S., Steel, D., Jacobsen, R. B., Lirazan, M. B., Cruz, L. J., Hooper, D., Shetty, R., DelaCruz, R. C., Nielsen, J. S., Zhou, L. M., Bandyopadhyay, P., Craig, A. G., and Olivera, B. M. (1999) The T-superfamily of conotoxins, J. Biol. Chem. 274, 30664-30671.
13. Hopkins, C., Grilley, M., Miller, C., Shon, K. J., Cruz, L. J., Gray, W. R., Dykert, J., Rivier, J., Yoshikami, D., and Olivera, B. M. (1995) A new family of Conus peptides targeted to the nicotinic acetylcholine receptor, J. Biol. Chem. 270, 22361-22367.
14. Jakubowski, J. A., Kelley, W. P., Sweedler, J. V., Gilly, W. F., and Schulz, J. R. (2005) Intraspecific variation of venom injected by fish-hunting Conus snails, J. Exp. Biol. 208, 2873-2883.
15. Clauser, K. R., Baker, P., and Burlingame, A. L. (1999) Role of accurate mass measurement (+/- 10 ppm) in protein identification strategies employing MS or MS MS and database searching, Anal. Chem. 71, 2871-2882.
16. 3H]saxitoxin and μ-conotoxins, Proc. Natl. Acad. Sci. U.S.A. 83, 5321-5325.
17. Gilly, W. F., and Brismar, T. (1989) Properties of appropriately and inappropriately expressed sodium channels in squid giant axon and its somata, J. Neurosci. 9, 1362-1374.
18. Bingham, J. P. (1998) Novel toxins from Conus. From taxonomy to toxins, Ph.D. Thesis, University of Queensland.
19. Garden, R. W., Moroz, T. P., Gleeson, J. M., Floyd, P. D., Li, L. J., Rubakhin, S. S., and Sweedler, J. V. (1999) Formation of N-pyroglutamyl peptides from N-Glu and N-Gln precursors in Aplysia neurons, J. Neurochem. 72, 676-681.
20. Santos, A. D., McIntosh, J. M., Hillyard, D. R., Cruz, L. J., and Olivera, B. M. (2004) The A-superfamily of conotoxins - structural and functional divergence, J. Biol. Chem. 279, 17596-17606.
21. Wang, C. Z., Jiang, H., Ou, Z. L., Chen, J. S., and Chi, C. W. (2003) cDNA cloning of two A-superfamily conotoxins from Conus striatus, Toxicon 42, 613-619.
22. Medzihradszky, K. F., Gillece-Castro, B. L., Settineri, C. A., Townsend, R. R., Masiarz, F. R., and Burlingame, A. L. (1990) Structure determination of O-linked glycopeptides by tandem mass spectrometry, Biomed. Environ. Mass Spectrom. 19, 777-781.
23. Medzihradszky, K. F., Gillececastro, B. L., Townsend, R. R., Burlingame, A. L., and Hardy, M. R. (1996) Structural elucidation of O-linked glycopeptides by high energy collision-induced dissociation, J. Am. Soc. Mass Spectrom. 7, 319-328.
24. Rademaker, G. J., Pergantis, S. A., Blok-Tip, L., Langridge, J. I., Kleen, A., and Thomas-Oates, J. E. (1998) Mass spectrometric determination of the sites of O-glycan attachment with low picomolar sensitivity, Anal. Biochem. 257, 149-160.
25. Mirgorodskaya, E., Hassan, H., Wandall, H. H., Clausen, H., and Roepstorff, P. (1999) Partial vapor-phase hydrolysis of peptide bonds: a method for mass spectrometric determination of O-glycosylated sites in glycopeptides, Anal. Biochem. 269, 54-65.
26. Terlau, H., Shon, K. J., Grilley, M., Stocker, M., Stuhmer, W., and Olivera, B. M. (1996) Strategy for rapid immobilization of prey by a fish-hunting marine snail, Nature 381, 148-151.
27. Breci, L. A., Tabb, D. L., Yates, J. R., and Wysocki, V. H. (2003) Cleavage N-terminal to proline: analysis of a database of peptide tandem mass spectra, Anal. Chem. 75, 1963-1971.
28. Tabb, D. L., Smith, L. L., Breci, L. A., Wysocki, V. H., Lin, D., and Yates, J. R. (2003) Statistical characterization of ion trap tandem mass spectra from doubly charged tryptic peptides, Anal. Chem. 75, 1155-1163.
29. Craig, A. G., Norberg, T., Griffin, D., Hoeger, C., Akhtar, M., Schmidt, K., Low, W., Dykert, J., Richelson, E., Navarro, V., Mazella, J., Watkins, M., Hillyard, D., Imperial, J., Cruz, L. J., and Olivera, B. M. (1999) Contulakin-G, an O-glycosylated invertebrate neurotensin, J. Biol. Chem. 274, 13752-13759.
30. Kalume, D. E., Stenflo, J., Czerwiec, E., Hambe, B., Furie, B. C., Furie, B., and Roepstorff, P. (2000) Structure determination of two conotoxins from Conus textile by a combination of matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization mass spectrometry and biochemical methods, J. Mass. Spectrom. 35, 145-156.
31. 2+ influx, Proc. Natl. Acad. Sci. U.S.A. 96, 5758-5763.
32. Borman, S. (2006) Glycosylation engineering: controlling personalities tame wild sugars on proteins and natural products, Chem. Eng. News 84, 13-22.
33. Endean, R., Gyr, P., and Surridge, J. (1977) The pharmacological actions on guinea-pig ileum of crude venoms from the marine gastropods Conus striatus and Conus magus, Toxicon 15, 327-337.
34. Endean, R., Surridge, J., and Gyr, P. (1977) Some effects of crude venom from the cones Conus striatus and Conus magus on isolated guinea-pig atria, Toxicon 15, 369-374.
35. Hahin, R., Wang, G. K., Shapiro, B. I., and Strichartz, G. (1991) Alterations in sodium channel gating produced by the venom of the marine mollusc Conus striatus, Toxicon 29, 245-259.
36. Caldwell, J. H., Shaller, K. L., Lasher, R. S., Peles, E., and Levinson, S. R. (2000) Sodium channel Nav1.6 is localized at nodes of Ranvier, dendrites and synapses, Proc. Natl. Acad. Sci. U.S.A. 97, 5616-5620.
37. Krzemien, D. M., Schaller, K. L., Levinson, S. R., and Caldwell, J. H. (2000) Immunolocalization of sodium channel isoform NaCh6 in the nervous system, J. Comp. Neurol. 420, 70-83.
38. Campbell, D. T. (1992) Large and small vertebrate sensory neurons express different Na and K channel subtypes, Proc. Natl. Acad. Sci. U.S.A. 89, 9569-9573.
39. Jonas, P., Brau, M. E., Hermsteiner, M., and Vogel, W. (1989) Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels, Proc. Natl. Acad. Sci. U.S.A. 86, 7238-7242.
40. Bayrhuber, M., Vijayan, V., Ferber, M., Graf, R., Korukottu, J., Imperial, J., Garrett, J. E., Olivera, B. M., Terlau, H., Zweckstetter, M., and Becker, S. (2005) Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization, J. Biol. Chem. 280, 23766-23770.
41. + channels and related peptides: biodiversity, structure-function relationships and evolution, Toxicon 46, 831-844.
42. Tenenholz, T. C., Klenk, K. C., Matteson, D. R., Blaustein, M. P., and Weber, D. J. (2000) Structural determinants of scorpion toxin affinity: the charybdotoxin (alpha-KTX) family of K(+)-channel blocking peptides, Rev. Physiol. Biochem. Pharmacol. 140, 135-185.
43. Duda, T. F., and Kohn, A. J. (2005) Species-level phylogeography and evolutionary history of the hyperdiverse marine gastropod genus Conus, Mol. Phylogenet. Evol. 34, 257-272.