Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver

Molecular and Cellular Biochemistry

Volumn 293, Issue 1-2, 2006, Pages 87-92

  Chiu, Po Yee ^a   Leung, Hoi Yan ^a   Poon, Michel K T ^a   Lee, Susanna S T ^b   Ko, Kam Ming ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

CytochromeP 450 2E1; Glutathione; Heat shock proteins; Knock out; Liver; Mitochondria; Schisandrin B

Indexed keywords

ANTIOXIDANT; CYTOCHROME P450 2E1; GLUTATHIONE; HEAT SHOCK PROTEIN 25; HEAT SHOCK PROTEIN 70; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCHISANDRIN B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG METABOLISM; DRUG STRUCTURE; FEMALE; IN VITRO STUDY; KNOCKOUT MOUSE; LIVER; LIVER MICROSOME; LIVER MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION; PROTEIN EXPRESSION; SINGLE DRUG DOSE; WILD TYPE;

ANIMALS; ANTIOXIDANTS; CATALYSIS; CYCLOOCTANES; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTATHIONE; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; LIGNANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; NADP; NEOPLASM PROTEINS; POLYCYCLIC COMPOUNDS;

EID: 33751582587     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-2957-3     Document Type: Article

References (21)

1. Hancke JL, Burgos RA, Ahumada F: Schisandra chinensis (Turcz.) Baill. Fitoterapia 70: 451-471, 1999
2. Ip SP, Poon MKT, Wu SS, Che CT, Ng KH, Kong YC, Ko KM: Effect of schisandrin B on hepatic glutathione antioxidant system in mice: protection against carbon tetrachloride toxicity. Planta Med 61: 398-401, 1995
3. Ko KM, Yiu HY: Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts. Mol Cell Biochem 220: 141-147, 2001
4. Ip SP, Ko KM: The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: A comparative study with butylated hydroxytoluene. Biochem Pharmacol 52: 1687-1693, 1996
5. Chiu PY, Ko KM: Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury. Biofactors 19: 43-51, 2003
6. Chiu PY, Tang MH, Mak DH, Poon MKT, Ko KM: Hepatoprotective mechanism of schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins. Free Radic Biol Med 35: 368-380, 2003
7. Chiu PY, Mak DHF, Poon MKT, Ko KM: Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver. Life Sci 77: 2887-2895, 2005
8. Gonzalez FJ: The molecular biology of cytochrome P450s. Pharmacol Rev 40: 243-288, 1988
9. Guengerich FP, Kim DH, Iwasaki M: Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 4: 168-179, 1991
10. Ortiz de Montellano PR, Mathews JM: Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct. Biochem J 195: 761-764, 1981
11. Evans WH: Isolation and characterization of membranes and cell organelles. In: Rickwood D (ed). Preparative Centrifugation: A Practical Approach, Oxford University Press: New York, 1992, pp 233-270
12. Griffith OW: Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106: 207-212, 1980
13. Chiu PY, Mak DH, Poon MKT, Ko KM: In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin. Planta Med 68: 951-956, 2002
14. Ip SP, Che CT, Kong YC, Ko KM: Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver. Cell Stress Chaperones 6: 44-48, 2001
15. Wong FW, Chan WY, Lee SS: Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol Appl Pharmacol 153: 109-118, 1998
16. Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez FJ: Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271: 12063-12067, 1996
17. Omiecinski CJ, Remmel RP, Hosagrahara VP: Concise review of the cytochrome P450s and their roles in toxicology. Toxicol Sci 48: 151-156, 1999
18. Lieber CS: CytoIhrome P-4502E1: its physiological and pathological role. Physiol Rev 77: 517-44.
19. Owuor, ED, Kong AN: Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol 64: 765-770, 1997
20. Paroo Z, Meredith MJ, Locke M, Haist JV, Karmazyn M, Noble EG: Redox signaling of cardiac HSF1 DNA binding. Am J Physiol Cell Physiol 283: C404-C411, 2002
21. Ip SP, Yiu HY, Ko KM: Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice. Mol Cell Biochem 205: 111-4, 2000