Seminal prostasomes inhibit the angiogenesis activity of rat aortic rings

Prostate Cancer and Prostatic Diseases

Volumn 9, Issue 4, 2006, Pages 444-447

  Delves, G H ^a,b   Goyal, A ^b   Lwaleed, B A ^c   Cooper, A J ^b  

^a ST MARY S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CHOLESTEROL; MEMBRANE LIPID; SPHINGOMYELIN;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CELL ORGANELLE; EPITHELIUM CELL; HEAT TREATMENT; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTASOME; PROSTATE EPITHELIUM; PROTEIN DENATURATION; QUANTITATIVE ANALYSIS; RAT; SPECTROPHOTOMETRY; SPERM; VASCULAR RING;

ANIMALS; AORTA, THORACIC; CELL CULTURE TECHNIQUES; EPITHELIAL CELLS; HUMANS; MALE; NEOVASCULARIZATION, PATHOLOGIC; ORGANELLES; PROSTATE; RATS; RATS, WISTAR; RESEARCH DESIGN; SEMINAL VESICLES; SPECTROPHOTOMETRY;

EID: 33751580490     PISSN: 13657852     EISSN: 14765608     Source Type: Journal    
DOI: 10.1038/sj.pcan.4500896     Document Type: Article

References (28)

1. Fabiani R, Johansson L, Lundkvist O, Ronquist G. Enhanced recruitment of motile spermatozoa by prostasome inclusion in swim-up medium. Hum Reprod 1994; 9: 1485-1489.
2. Palmerini CA, Saccardi C, Carlini E, Fabiani R, Arienti G. Fusion of prostasomes to human spermatozoa stimulates the acrosome reaction. Fertil Steril 2003; 80: 1181-1184.
3. Kelly RW, Holland P, Skibinski G, Harrison C, McMillan L, Hargreave T et al. Extracellular organelles (prostasomes) are immunosuppressive components of human semen. Clin Exp Immunol 1991; 86: 550-556.
4. Saez F, Motta C, Boucher D, Grizard G. Antioxidant capacity of prostasomes in human semen. Mol Hum Reprod 1998; 4: 667-672.
5. Utleg AG, Yi EC, Xie T, Shannon P, White JT, Goodlett DR et al. Proteomic analysis of human prostasomes. Prostate 2003; 56: 150-161.
6. Fernandez JA, Heeb MJ, Radtke KP, Griffin JH. Potent blood coagulant activity of human semen due to prostasome-bound tissue factor. Biol Reprod 1997; 56: 757-763.
7. Schrimpf SP, Hellman U, Carlsson L, Larsson A, Ronquist G, Nilsson BO. Identification of dipeptidyl peptidase IV as the antigen of a monoclonal anti-prostasome antibody. Prostate 1999; 38: 35-39.
8. Arvidson G, Ronquist G, Wikander G, Ojteg AC. Human prostasome membranes exhibit very high cholesterol/phospholipid ratios yielding high molecular ordering. Biochim Biophys Acta 1989; 984: 167-173.
9. Nilsson BO, Lennartsson L, Carlsson L, Nilsson S, Ronquist G. Expression of prostasome-like granules by the prostate cancer cell lines PC3, Du145 and LnCaP grown in monolayer. Ups J Med Sci 1999; 104: 199-206.
10. Carlsson L, Nilsson O, Larsson A, Stridsberg M, Sahlen G, Ronquist G. Characteristics of human prostasomes isolated from three different sources. Prostate 2003; 54: 322-330.
11. Ronquist G, Nilsson BO. The Janus-faced nature of prostasomes: Their pluripotency favours the normal reproductive process and malignant prostate growth. Prostate Cancer Prostatic Dis 2004; 7: 21-31.
12. Carlsson L, Lennartsson L, Nilsson BO, Nilsson S, Ronquist G. Growth-inhibitory effect of prostasomes on prostatic cancer cell lines in culture. Eur Urol 2000; 38: 468-474.
13. Delves GH, Stewart AB, Lwaleed BA, Cooper AJ. In vitro inhibition of angiogenesis by prostasomes. Prostate Cancer Prostatic Dis 2005; 8: 174-178.
14. Wang HS, Hwang LL, Sue HF, Lee KM, Chen CT. A simple quantitative method for evaluation of angiogenesis activity. Assay Drug Dev Technol 2004; 2: 31-38.
15. Ronquist G, Brody I. The prostasome: Its structure and function in man. Biochem Biophys Acta 1985; 822: 203-218.
16. Laurell CB, Weiber H, Ohlsson K, Ranevic G. A zinc-dependent peptidase in prostatic organelles present in seminal plasma. Clin Chem Acta 1982; 126: 161-169.
17. Olsson I, Ronquist G. Nucleic acid association to human prostasomes. Arch Androl 1990; 24: 1-10.
18. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
19. Kim CW, Lee HM, Lee TH, Kang C, Kleinman HK, Gho YS. Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin. Cancer Res 2002; 62: 6312-6317.
20. Scopes RK. Protein Purification: Principles and Practice, 3rd edn. Springer-Verlag New York, Inc.: USA, 1994, pp. 95-101.
21. Arienti G, Saccardi C, Carlini E, Verdacchi R, Palmerini CA. Distribution of lipid and protein in human semen fractions. Clin Chim Acta 1999; 289: 111-120.
22. Arienti G, Polci A, Carlini E, Palmerini CA. Transfer of CD26/dipeptidyl peptidase (E.C.3.5.4.4.) from prostasomes to sperm. FEBS Lett 1997; 410: 343-346.
23. Arienti G, Carlini E, Verdacchi R, Palmerini CA. Transfer of aminopeptidase activity from prostasomes to sperm. Biochem Biophys Acta 1997; 1336: 269-274.
24. Carlini E, Palmerini A, Cosmi EV, Arienti G. Fusion of sperm with prostasomes: Effects on membrane fluidity. Arch Biochem Biophys 1997; 343: 6-12.
25. Saez F, Motta C, Boucher D, Grizard G. Prostasomes inhibit the NADPH oxidase activity of human neutrophils. Mol Hum Reprod 2000; 6: 883-891.
26. Kelly RW, Holland P, Skibinski G, Harrison C, McMillan L, Hargreave T et al. Extracellular organelles (prostasomes) are immunosuppressive components of human semen. Clin Exp Immunol 1991; 86: 550-556.
27. Hicks JA, Anderson WM, Lwaleed BA, Cooper AJ, Holmes SAV. Do CD142 carrying prostatic exosomes promote angiogenesis. Poster presented to British Association of Urological Surgeons annual meeting 2005. Abstract BJU Int 2005; 95 (Suppl 5): 81.
28. Van Blitterswijk WJ, De Veer G, Krol JH, Emmelot P. Comparative lipid analysis of purified plasma membranes and shed extracellular membrane vesicles from normal murine thymocytes and leukemic GRSL cells. Biochim Biophys Acta 1982; 688: 495-504.