-
1
-
-
0015882144
-
Disposition of propranolol. V. Drug accumulation and steady-state concentrations during chronic oral administration in man
-
Evans, G. H. and Shand, D. G.: Disposition of propranolol. V. Drug accumulation and steady-state concentrations during chronic oral administration in man. Clin. Pharmacol. Ther., 14: 487-493 (1973).
-
(1973)
Clin. Pharmacol. Ther.
, vol.14
, pp. 487-493
-
-
Evans, G.H.1
Shand, D.G.2
-
2
-
-
0023257082
-
Nonlinear pharmacokinetics of unbound propranolol after oral administration
-
Straka, R. J., Lalonde, R. L., Pieper, J. A., Bottorff, M. B. and Mirvis, D. M.: Nonlinear pharmacokinetics of unbound propranolol after oral administration. J. Pharm. Sci., 76: 521-524 (1987).
-
(1987)
J. Pharm. Sci.
, vol.76
, pp. 521-524
-
-
Straka, R.J.1
Lalonde, R.L.2
Pieper, J.A.3
Bottorff, M.B.4
Mirvis, D.M.5
-
3
-
-
0019362164
-
The inhibitory effect of propranolol pretreatment on its own metabolism in the rat
-
Schneck, D. W. and Pritchard, J. F.: The inhibitory effect of propranolol pretreatment on its own metabolism in the rat. J. Pharmacol. Exp. Ther., 218: 575-581 (1981).
-
(1981)
J. Pharmacol. Exp. Ther.
, vol.218
, pp. 575-581
-
-
Schneck, D.W.1
Pritchard, J.F.2
-
4
-
-
0026031356
-
Impairment of debrisoquine 4-hydroxylase and related monooxygenase activities in the rat following treatment with propranolol
-
Masubuchi, Y., Fujita, S., Chiba, M., Kagimoto, N., Umeda, S. and Suzuki, T.: Impairment of debrisoquine 4-hydroxylase and related monooxygenase activities in the rat following treatment with propranolol. Biochem. Pharmacol., 41: 861-865 (1991).
-
(1991)
Biochem. Pharmacol.
, vol.41
, pp. 861-865
-
-
Masubuchi, Y.1
Fujita, S.2
Chiba, M.3
Kagimoto, N.4
Umeda, S.5
Suzuki, T.6
-
5
-
-
0030572727
-
Cytochrome P450 enzymes involved in the enhancement of propranolol N-desisopropylation after repeated administration of propranolol in rats
-
Narimatsu, S., Mochida, M., Matsumoto, T., Masubuchi, Y., Horie, T., Nagata, K., Funae, Y., Cho, A. K. and Suzuki, T.: Cytochrome P450 enzymes involved in the enhancement of propranolol N-desisopropylation after repeated administration of propranolol in rats. Chemico-Biol. Interact., 101: 207-224 (1996).
-
(1996)
Chemico-Biol. Interact.
, vol.101
, pp. 207-224
-
-
Narimatsu, S.1
Mochida, M.2
Matsumoto, T.3
Masubuchi, Y.4
Horie, T.5
Nagata, K.6
Funae, Y.7
Cho, A.K.8
Suzuki, T.9
-
6
-
-
0029056763
-
Characterization of a chemically reactive propranolol metabolite that bind to microsomal proteins of rat liver
-
Narimatsu, S., Watanabe, T., Mochida, M., Masubuchi, Y., Horie, T., Kumagai, Y., Cho, A. K., Imaoka, S., Funae, Y., Ishikawa, T. and Suzuki, T.: Characterization of a chemically reactive propranolol metabolite that bind to microsomal proteins of rat liver. Chem. Res. Toxicol., 8: 721-728 (1995).
-
(1995)
Chem. Res. Toxicol.
, vol.8
, pp. 721-728
-
-
Narimatsu, S.1
Watanabe, T.2
Mochida, M.3
Masubuchi, Y.4
Horie, T.5
Kumagai, Y.6
Cho, A.K.7
Imaoka, S.8
Funae, Y.9
Ishikawa, T.10
Suzuki, T.11
-
7
-
-
0030938658
-
Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins in the rat
-
Narimatsu, S., Arai, T., Watanabe, T., Horie, T., Suzuki, T., Ishikawa, T., Tsutsui, M., Kumagai, Y. and Cho, A. K.: Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins in the rat. Chem. Res. Toxicol., 10: 289-295 (1997).
-
(1997)
Chem. Res. Toxicol.
, vol.10
, pp. 289-295
-
-
Narimatsu, S.1
Arai, T.2
Watanabe, T.3
Horie, T.4
Suzuki, T.5
Ishikawa, T.6
Tsutsui, M.7
Kumagai, Y.8
Cho, A.K.9
-
8
-
-
0034833723
-
Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol
-
Narimatsu, S., Arai, T., Masubuchi, Y., Horie, T., Hosokawa, M., Ueno, K., Kataoka, H., Yamamoto, S., Ishikawa, T. and Cho, A K.: Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol. Biol. Pharm. Bull., 24: 988-994 (2001).
-
(2001)
Biol. Pharm. Bull.
, vol.24
, pp. 988-994
-
-
Narimatsu, S.1
Arai, T.2
Masubuchi, Y.3
Horie, T.4
Hosokawa, M.5
Ueno, K.6
Kataoka, H.7
Yamamoto, S.8
Ishikawa, T.9
Cho, A.K.10
-
9
-
-
0027500823
-
Regioselective contribution of the cytochrome P-450 2D subfamily to propranolol metabolism in rat liver microsomes
-
Y. Masubuchi, N. Kagimoto, S. Narimatsu, S. Fujita and T. Suzuki. Regioselective contribution of the cytochrome P-450 2D subfamily to propranolol metabolism in rat liver microsomes. Drug Metab. Dispos., 21, 1012-1016 (1993).
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 1012-1016
-
-
Masubuchi, Y.1
Kagimoto, N.2
Narimatsu, S.3
Fujita, S.4
Suzuki, T.5
-
10
-
-
0028020099
-
Cytochrome P-450 isozymes involved in propranolol metabolism in human liver microsomes: The role of CYP-2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase
-
Masubuchi, Y., Hosokawa, S., Horie, T., Ohmori, S., Kitada, M., Suzuki, T. and Narimatsu, S.: Cytochrome P-450 isozymes involved in propranolol metabolism in human liver microsomes: The role of CYP-2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab. Dispos., 22: 909-915 (1994).
-
(1994)
Drug Metab. Dispos.
, vol.22
, pp. 909-915
-
-
Masubuchi, Y.1
Hosokawa, S.2
Horie, T.3
Ohmori, S.4
Kitada, M.5
Suzuki, T.6
Narimatsu, S.7
-
11
-
-
0030885306
-
Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes
-
Masubuchi, Y., Iwasa, T., Hosokawa, S., Suzuki, T., Horie, T., Imaoka, S., Funae, Y. and Narimatsu, S.: Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes. J. Pharamcol. Exp. Ther., 282: 1435-1441 (1997).
-
(1997)
J. Pharamcol. Exp. Ther.
, vol.282
, pp. 1435-1441
-
-
Masubuchi, Y.1
Iwasa, T.2
Hosokawa, S.3
Suzuki, T.4
Horie, T.5
Imaoka, S.6
Funae, Y.7
Narimatsu, S.8
-
12
-
-
0021200785
-
Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene
-
Gonzalez, F. J., Tukey, R. H. and Nebert, D. W.: Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene. Mol. Pharmacol., 26: 117-121 (1984).
-
(1984)
Mol. Pharmacol.
, vol.26
, pp. 117-121
-
-
Gonzalez, F.J.1
Tukey, R.H.2
Nebert, D.W.3
-
13
-
-
0019461164
-
Ring-hydroxylated propranolol: synthesis and beta-receptor antagonist and vasodilating activities of the seven isomers
-
Oatis, J. E., Russell, M. P., Knapp, D. R. and Walle, T.: Ring-hydroxylated propranolol: synthesis and beta-receptor antagonist and vasodilating activities of the seven isomers. J. Med. Chem., 24: 309-314 (1981).
-
(1981)
J. Med. Chem.
, vol.24
, pp. 309-314
-
-
Oatis, J.E.1
Russell, M.P.2
Knapp, D.R.3
Walle, T.4
-
14
-
-
78651165715
-
The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
-
Omura, T. and Sato, R.: T. Omura, R. Sato. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem., 239: 2370-2378 (1964).
-
(1964)
J. Biol. Chem.
, vol.239
, pp. 2370-2378
-
-
Omura, T.1
Sato, R.2
Omura, T.3
Sato, R.4
-
15
-
-
0017363296
-
Characteristics of a microsomal cytochrome P-448-mediated reaction. Ethoxyresorufin O-deethylation
-
Burke, M. D. Prough, R. A. and Mayer, R. T.: Characteristics of a microsomal cytochrome P-448-mediated reaction. Ethoxyresorufin O-deethylation. Drug Metab. Dispos., 5: 1-8 (1977).
-
(1977)
Drug Metab. Dispos.
, vol.5
, pp. 1-8
-
-
Burke, M.D.1
Prough, R.A.2
Mayer, R.T.3
-
16
-
-
0020519724
-
In vivo O-de-ethylation of phenacetin in 3-methylcholanthrene-pretreated rats: gut wall and liver first-pass metabolism
-
Klippert, P. J., Littel, R. J. and Noordhoek, J.: In vivo O-de-ethylation of phenacetin in 3-methylcholanthrene-pretreated rats: gut wall and liver first-pass metabolism. J. Pharmacol. Exp. Ther., 225: 153-157 (1983).
-
(1983)
J. Pharmacol. Exp. Ther.
, vol.225
, pp. 153-157
-
-
Klippert, P.J.1
Littel, R.J.2
Noordhoek, J.3
-
17
-
-
0025194581
-
High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat
-
Sesardic, D., Edwards, R. J. Davies, D. S., Thomas, P. E., Levin, W. and Boobis A. R.: High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat. Biochem. Pharmacol., 39: 489-498 (1990).
-
(1990)
Biochem. Pharmacol.
, vol.39
, pp. 489-498
-
-
Sesardic, D.1
Edwards, R.J.2
Davies, D.S.3
Thomas, P.E.4
Levin, W.5
Boobis, A.R.6
-
18
-
-
0023857962
-
Possible mechanism of Sudan III-induced prevention of chemical carcinogenesis in rats
-
Fujita, S., Matsunaga, T., Masubuchi, Y. and Suzuki, T.: Possible mechanism of Sudan III-induced prevention of chemical carcinogenesis in rats. Cancer Res., 48: 254-259 (1988).
-
(1988)
Cancer Res.
, vol.48
, pp. 254-259
-
-
Fujita, S.1
Matsunaga, T.2
Masubuchi, Y.3
Suzuki, T.4
-
19
-
-
0024310194
-
Evaluation of the involvement of a male specific cytochrome P-450 isozyme in senescence-associated decline of hepatic drug metabolism in male rats
-
Fujita, S., Morimoto, R., Chiba, M., Kitani, K. and Suzuki, T.: Evaluation of the involvement of a male specific cytochrome P-450 isozyme in senescence-associated decline of hepatic drug metabolism in male rats. Biochem. Pharmacol., 38: 3925-3931 (1989).
-
(1989)
Biochem. Pharmacol.
, vol.38
, pp. 3925-3931
-
-
Fujita, S.1
Morimoto, R.2
Chiba, M.3
Kitani, K.4
Suzuki, T.5
-
20
-
-
0026639457
-
Purification and characterization of a cytochrome P-450 isozyme catalyzing bunitrolol 4-hydroxylation in liver microsomes of male rats
-
Suzuki, T., Narimatsu, S., Fujita, S., Masubuchi, Y., Umeda, S., Imaoka, S. and Funae, Y.: Purification and characterization of a cytochrome P-450 isozyme catalyzing bunitrolol 4-hydroxylation in liver microsomes of male rats. Drug Metab. Dispos., 20: 367-373 (1992).
-
(1992)
Drug Metab. Dispos.
, vol.20
, pp. 367-373
-
-
Suzuki, T.1
Narimatsu, S.2
Fujita, S.3
Masubuchi, Y.4
Umeda, S.5
Imaoka, S.6
Funae, Y.7
-
21
-
-
0020028678
-
Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis
-
Guengerich, F. P., Wang, P. and Davidson, N. K.: Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochemistry, 21: 1698-1706 (1982).
-
(1982)
Biochemistry
, vol.21
, pp. 1698-1706
-
-
Guengerich, F.P.1
Wang, P.2
Davidson, N.K.3
-
22
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193: 265-275 (1951).
-
(1951)
J. Biol. Chem.
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
-
23
-
-
0023372766
-
Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast
-
Kimura, S., Smith, H. H., Hankinson, O. and Nebert, D. W.: Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast. EMBO J., 6: 1929-1933 (1987).
-
(1987)
EMBO J.
, vol.6
, pp. 1929-1933
-
-
Kimura, S.1
Smith, H.H.2
Hankinson, O.3
Nebert, D.W.4
-
24
-
-
0021771147
-
Mouse cytochrome P3-450: complete cDNA and amino acid sequence
-
Kimura, S., Gonzalez, F. J. and Nebert, D. W.: Mouse cytochrome P3-450: complete cDNA and amino acid sequence. Nucleic Acids Res., 12: 2917-2928 (1984)
-
(1984)
Nucleic Acids Res.
, vol.12
, pp. 2917-2928
-
-
Kimura, S.1
Gonzalez, F.J.2
Nebert, D.W.3
-
25
-
-
0026356151
-
Induction of cytochromes P450IA1 and P450IA2 and measurement of catalytic activities
-
eds. by Waterman, R., Johnson, E. F., Academic Press, San Diego
-
Rodrigues, A. D. and Prough, R. A.: Induction of cytochromes P450IA1 and P450IA2 and measurement of catalytic activities. Methods Enzymol., Vol. 206, pp. 423-431, eds. by Waterman, R., Johnson, E. F., Academic Press, San Diego, 1991.
-
(1991)
Methods Enzymol.
, vol.206
, pp. 423-431
-
-
Rodrigues, A.D.1
Prough, R.A.2
-
26
-
-
0027179679
-
Methoxyresorufin and benzylox-yresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse
-
Nerurkar, P. V., Park, S. S., Thomas, P. E., Nims, R. W. and Lubet R. A.: Methoxyresorufin and benzylox-yresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochem. Pharmacol., 46: 933-943 (1993).
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 933-943
-
-
Nerurkar, P.V.1
Park, S.S.2
Thomas, P.E.3
Nims, R.W.4
Lubet, R.A.5
-
27
-
-
0026750059
-
Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2
-
Lambrecht, R. W., Sinclair, P. R., Gorman, N. and Sinclair, J. F.: Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2. Arch. Biochem. Biophys., 294: 504-510 (1992).
-
(1992)
Arch. Biochem. Biophys.
, vol.294
, pp. 504-510
-
-
Lambrecht, R.W.1
Sinclair, P.R.2
Gorman, N.3
Sinclair, J.F.4
-
28
-
-
0032923785
-
Induction of cytochrome P4501A1
-
Whitlock, J. P. Jr.: Induction of cytochrome P4501A1. Ann. Rev. Pharmacolo. Toxicol., 39: 103-125 (1999).
-
(1999)
Ann. Rev. Pharmacolo. Toxicol.
, vol.39
, pp. 103-125
-
-
Whitlock, J.P.1
-
29
-
-
0032765842
-
Signal transduction-mediated CYP1A1 induction by omeprazole in human HepG2 cells
-
Kikuchi, H. and Hossain, A.: Signal transduction-mediated CYP1A1 induction by omeprazole in human HepG2 cells. Exp. Toxicol. Pathol., 51: 342-346 (1999).
-
(1999)
Exp. Toxicol. Pathol.
, vol.51
, pp. 342-346
-
-
Kikuchi, H.1
Hossain, A.2
|