High-dose chemotherapy and autologous peripheral blood stem cell transplantation in adult patients with high-risk or advanced Ewing and soft tissue sarcoma

Journal of Cancer Research and Clinical Oncology

Volumn 133, Issue 1, 2007, Pages 1-11

  Engelhardt, M ^a   Zeiser, R ^a,c   Ihorst, G ^b   Finke, J ^a   Muller C I ^a,d  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autologous stem cell transplantation; Ewing sarcoma; High dose chemotherapy; Soft tissue sarcoma

Indexed keywords

BUSULFAN; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; IFOSFAMIDE; MELPHALAN; THIOTEPA; TOPOTECAN; VINCRISTINE;

ADULT; ARTICLE; AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; EWING SARCOMA; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HIGH RISK POPULATION; HUMAN; KARNOFSKY PERFORMANCE STATUS; MALE; METASTASIS; MULTIMODALITY CANCER THERAPY; OVERALL SURVIVAL; PNEUMONIA; PRIORITY JOURNAL; PROGNOSIS; RESPIRATORY FAILURE; RHABDOMYOSARCOMA; SEPTICEMIA; SOFT TISSUE SARCOMA; TREATMENT OUTCOME;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; NEOPLASM STAGING; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PROGNOSIS; PROSPECTIVE STUDIES; RHABDOMYOSARCOMA; RISK FACTORS; SARCOMA; SARCOMA, EWING'S; SURVIVAL ANALYSIS; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME;

EID: 33751509675     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-006-0137-1     Document Type: Article

References (37)

1. Atra A, Whelan JS, Calvagna V, Shankar AG, Ashley S, Shepherd V, Souhami RL, Pinkerton CR (1997) High-dose busulphan/melphalan with autologous stem cell rescue in Ewing's sarcoma. Bone Marrow Transplant 20:843-846
2. Barker LM, Pendergrass TW, Sanders JE, Hawkins DS (2005) Survival after recurrence of Ewing's sarcoma family of tumors. J Clin Oncol 23:4354-4362
3. Blay JY, Bouhour D, Ray-Coquard I, Dumontet C, Philip T, Biron P (2000) High-dose chemotherapy with autologous hematopoietic stem-cell transplantation for advanced soft tissue sarcoma in adults. J Clin Oncol 18:3643-3650
4. Burdach S, van Kaick B, Laws HJ, Ahrens S, Haase R, Korholz D, Pape H, Dunst J, Kahn T, Willers R, Engel B, Dirksen U, Kramm C, Nurnberger W, Heyll A, Ladenstein R, Gadner H, Jurgens H, Go el U (2000) Allogeneic and autologous stem-cell transplantation in advanced Ewing tumor: an update after long-term follow-up from two centers of the European intergroup study EICESS. Stem-cell transplant programs at Dusseldorf University Medical Center, Germany and St. Anna Kinderspital, Vienna, Austria. Ann Oncol 11:1451-1462
5. Burgert EO Jr, Nesbit ME, Garnsey LA, Gehan EA, Herrmann J, Vietti TJ, Cangir A, Tefft M, Evans R, Thomas P (1990) Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: intergroup study IESS-II. J Clin Oncol 8:1514-1524
6. Clark MA, Fisher C, Judson I, Thomas JM (2005) Soft-tissue sarcomas in adults. N Engl J Med 353:701-711
7. Craft AW, Cotterill SJ, Bullimore JA, Pearson D (1997) Long-term results from the first UKCCSG Ewing's tumours study (ET-1). United Kingdom children's cancer study group (UKCCSG) and the medical research council bone sarcoma working party. Eur J Cancer 33:1061-1069
8. Craft A, Cotterill S, Malcolm A, Spooner D, Grimer R, Souhami R, Imeson J, Lewis I (1998) Ifosfamide-containing chemotherapy in Ewing's sarcoma: the second United Kingdom children's cancer study group and the medical research council Ewing's tumor study. J Clin Oncol 16:3628-3633
9. Cotterill SJ, Ahrens S, Paulussen M, Jurgens HF, Voute PA, Gadner H, Craft AW (2000) Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from European intergroup cooperative Ewing's sarcoma study group. J Clin Oncol 18:3108-3114
10. Diaz MA, Vicent MG, Madero L (1999) High-dose busulfan/melphalan as conditioning for autologous PBSC transplantation in pediatric patients with solid tumors. Bone Marrow Transplant 24:1157-1159
11. Du S, Lawrence EJ, Strzelecki D, Rajput P, Xia SJ, Gottesman DM, Barr FG (2005) Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma. Int J Cancer 115:85-92
12. Engelhardt M, Douville J, Behringer D, Jahne A, Smith A, Henschler R, Lange W (2001) Hematopoietic recovery of ex vivo perfusion culture expanded bone marrow and unexpanded peripheral blood progenitors after myeloablative chemotherapy. Bone Marrow Transplant 27:249-259
13. Evans RG, Nesbit ME, Gehan EA, Garnsey LA, Burgert O Jr, Vietti TJ, Cangir A, Tefft M, Thomas P, Askin FB (1991) Multimodal therapy for the management of localized Ewing's sarcoma of pelvic and sacral bones: a report from the second intergroup study. J Clin Oncol 9:1173-1180
14. Fischmeister G, Zoubek A, Jugovic D, Witt V, Ladenstein R, Fritsch G, Hocker P, Gadner H, Kovar H (1999) Low incidence of molecular evidence for tumour in PBPC harvests from patients with high risk Ewing tumours. Bone Marrow Transplant 24:405-409
15. Fizazi K, Dohollou N, Blay JY, Guerin S, Le Cesne A, Andre F, Pouillart P, Tursz T, Nguyen BB (1998) Ewing's family of tumors in adults: multivariate analysis of survival and long-term results of multimodality therapy in 182 patients. J Clin Oncol 16:3736-3743
16. Gronchi A, Casali PG, Mariani L, Miceli R, Fiore M, Lo Vullo S, Bertulli R, Collini P, Lozza L, Olmi P, Rosai J (2005) Status of surgical margins and prognosis in adult soft tissue sarcomas of the extremities: a series of patients treated at a single institution. J Clin Oncol 23:96-104
17. Harousseau JL (1999) Optimizing peripheral blood progenitor cell autologous transplantation in multiple myeloma. Haematologica 84:548-553
18. Hawkins D, Barnett T, Bensinger W, Gooley T, Sanders J (2000) Busulfan, melphalan, and thiotepa with or without total marrow irradiation with hematopoietic stem cell rescue for poor-risk Ewing-sarcoma-family tumors. Med Pediatr Oncol 34:328-337
19. Horowitz ME, Kinsella TJ, Wexler LH, Belasco J, Triche T, Tsokos M, Steinberg SM, McClure L, Longo DL, Steis RG (1993) Total-body irradiation and autologous bone marrow transplant in the treatment of high-risk Ewing's sarcoma and rhabdomyosarcoma. J Clin Oncol 11:1911-1918
20. Huang HY, Illei PB, Zhao Z, Mazumdar M, Huvos AG, Healey JH, Wexler LH, Gorlick R, Meyers P, Ladanyi M (2005) Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse. J Clin Oncol 23:548-558
21. Issels RD (1995) Soft tissue sarcomas - what is currently being done. Eur J Surg Oncol 21:471-474
22. Jenkin RD, Al-Fawaz I, Al-Shabanah MO, Allam A, Ayas M, Memon M, Rifai S, Schultz HP (2001) Metastatic Ewing sarcoma/PNET of bone at diagnosis: prognostic factors-a report from Saudi Arabia. Med Pediatr Oncol 37:383-389
23. Kasper B, Lehnert T, Bernd L, Mechtersheimer G, Goldschmidt H, Ho AD, Egerer G (2004) High-dose chemotherapy with autologous peripheral blood stem cell transplantation for bone and soft-tissue sarcomas. Bone Marrow Transplant 34:37-41
24. Kushner BH, Meyers PA (2001) How effective is dose-intensive/ myeloablative therapy against Ewing's sarcoma/primitive neuroectodermal tumor metastatic to bone or bone marrow? The memorial Sloan-Kettering experience and literature review. J Clin Oncol 19:870-880
25. Marina N, Meyers PA (2005) High-dose therapy and stem-cell rescue for Ewing's family of tumors in second remission. J Clin Oncol 23:4262-4264
26. Marina NM, Pappo AS, Parham DM, Cain AM, Rao BN, Poquette CA, Pratt CB, Greenwald C, Meyer WH (1999) Chemotherapy dose-intensification for pediatric patients with Ewing's family of tumors and desmoplastic small round-cell tumors: a feasibility study at St. Jude children's research hospital. J Clin Oncol 17:180-190
27. Meyers PA, Krailo MD, Ladanyi M, Chan KW, Sailer SL, Dickman PS, Baker DL, Davis JH, Gerbing RB, Grovas A, Herzog CE, Lindsley KL, Liu-Mares W, Nachman JB, Sieger L, Wadman J, Gorlick RG (2001) High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis. J Clin Oncol 19:2812-2820
28. Oberlin O, Deley MC, Bui BN, Gentet JC, Philip T, Terrier P, Carrie C, Mechinaud F, Schmitt C, Babin-Boillettot A, Michon J, French Society of Paediatric Oncology (2001) Prognostic factors in localized Ewing's tumours and peripheral neuroectodermal tumours: the third study of the French society of paediatric oncology (EW88 study). Br J Cancer 85:1646-1654
29. Paulussen M, Ahrens S, Burdach S, Craft A, Dockhorn-Dworniczak B, Dunst J, Frohlich B, Winkelmann W, Zoubek A, Jurgens H (1998) Primary metastatic (stage IV) Ewing tumor: survival analysis of 171 patients from the EICESS studies. European intergroup cooperative Ewing sarcoma studies. Ann Oncol 9:275-281
30. Pinkerton CR, Bataillard A, Guillo S, Oberlin O, Fervers B, Philip T (2001) Treatment strategies for metastatic Ewing's sarcoma. Eur J Cancer 37:1338-1344
31. Rosito P, Mancini AF, Rondelli R, Abate ME, Pession A, Bedei L, Bacci G, Picci P, Mercuri M, Ruggieri P, Frezza G, Campanacci M, Paolucci G (1999) Italian cooperative study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience. Cancer 86:421-428
32. Sluga M, Windhager R, Lang S, Heinzl H, Krepler P, Mittermayer F, Dominkus M, Zoubek A, Kotz R (2001) A long-term review of the treatment of patients with Ewing's sarcoma in one institution. Eur J Surg Oncol 27:569-573
33. Stewart DA, Gyonyor E, Paterson AH, Arthur K, Temple W, Schachar NS, Klassen J, Brown C, Russell JA (1996) Highdose melphalan +/- total body irradiation and autologous hematopoietic stem cell rescue for adult patients with Ewing's sarcoma or peripheral neuroectodermal tumor. Bone Marrow Transplant 18:315-318
34. Strauss SJ, McTiernan A, Driver D, Hall-Craggs M, Sandison A, Cassoni AM, Kilby A, Michelagnoli M, Pringle J, Cobb J, Briggs T, Cannon S, Witt J, Whelan JS (2003) Single center experience of a new intensive induction therapy for Ewing's family of tumors: feasibility, toxicity, and stem cell mobilization properties. J Clin Oncol 21:2974-2981
35. Williams BA, Williams KM, Doyle J, Stephens D, Greenberg M, Malkin D, Pappo AS (2004) Metastatic rhabdomyosarcoma: a retrospective review of patients treated at the hospital for sick children between 1989 and 1999. J Pediatr Hematol Oncol 26:243-247
36. Yaniv I, Cohen IJ, Stein J, Zilberstein J, Liberzon E, Atlas O, Grunshpan A, Sverdlov Y, Ash S, Zaizov R, Avigad S (2004) Tumor cells are present in stem cell harvests of Ewings sarcoma patients and their persistence following transplantation is associated with relapse. Pediatr Blood Cancer 42:404-409
37. Zeiser R, Deschler B, Bertz H, Finke J, Engelhardt M (2004) Extramedullary vs medullary relapse after autologous or allogeneic hematopoietic stem cell transplantation (HSCT) in multiple myeloma (MM) and its correlation to clinical outcome. Bone Marrow Transplant 34:1057-1065