Lack of Significant Effects of Methionine Loading on Endothelial Function in Elderly Volunteers

Heart Lung and Circulation

Volumn 15, Issue 6, 2006, Pages 358-361

  Hart, Simon R ^a   Mangoni, Arduino A ^b   Swift, Cameron G ^c   Jackson, Stephen H D ^c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b FLINDERS UNIVERSITY   (Australia)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cardiovascular risk; Endothelial dysfunction; Homocysteine; Methionine

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; C REACTIVE PROTEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHIONINE; OXIDIZED LOW DENSITY LIPOPROTEIN; PLACEBO; TRIACYLGLYCEROL;

ADULT; AGED; ARTERY BLOOD FLOW; ARTICLE; BRACHIAL ARTERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; HYPERHOMOCYSTEINEMIA; LOADING TEST; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR ENDOTHELIUM; VASODILATATION; VOLUNTEER;

AGED; AGED, 80 AND OVER; BRACHIAL ARTERY; C-REACTIVE PROTEIN; CHOLESTEROL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; LIPOPROTEINS; METHIONINE; PLACEBOS; REGIONAL BLOOD FLOW; TIME FACTORS; TRIGLYCERIDES;

EID: 33751502537     PISSN: 14439506     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hlc.2006.08.001     Document Type: Article

References (17)

1. Haynes W.G. Homocysteine and atherosclerosis: potential mechanisms and clinical implications. Pro R Coll Phys Edinb 30 (2000) 114-122
2. Still R., and McDowell I. Clinical implications of homocysteine measurement in cardiovascular disease. J Clin Pathol 51 (1998) 183-188
3. Hart S.R., and Iversen A. Plasma homocysteine: Implications for setting a reference range. Age Aging Suppl 30 1 (2001) 31
4. Chambers J., Obeid O., and Kooner J. Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects. Arterioscler Thromb Vasc Biol 19 12 (1999) 2922-2927
5. Takawol A., Omland T., Gerhard M., Wu J.T., and Creager M.A. Hyperhomocyst(e)inaemia is associated with impaired endothelium dependent vasodilatation in humans. Circulation 95 5 (1997) 1119-1121
6. Bellamy M.F., McDowell I.F., Ramsey M.W., Brownlee M., Bones C., Newcombe R.G., et al. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation 98 (1998) 1848-1852
7. Chambers J.C., McGregor A., Jean-Marie J., Obeid O.A., and Kooner J.S. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 99 (1999) 1156-1160
8. Kanani P.M., Sinkey C.A., Browning R.L., Allaman M., Knapp H.R., and Haynes W.G. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation 100 (1999) 1161-1168
9. Nappo F., De Rosa N., Marfella R., De Lucia D., Ingrosso D., Perna A.F., et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA 281 (1999) 2113-2118
10. Kanani P.M., Sinkey C.A., Browning R.L., Allaman M., Knapp H.R., and Haynes W.G. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocysteinemia in humans. Circulation 100 (1999) 1161-1168
11. Al-Shaer M.H., Raghuveer G., Browning R., Sinkey C., Chenard C., Stumbo P., et al. Effect of hyperhomocysteinemia induced by methionine administration on flow-mediated dilatation of the brachial artery in healthy subjects. Am J Cardiol 95 3 (2005) 428-430
12. Loscalzo J. The oxidant stress of hyperhomocysteinemia. J Clin Invest 98 (1996) 5-7
13. Tsai J.C., Perrella M.A., Yoshizumi M., Hsieh C.M., Haber E., Schlegel R., et al. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci USA 91 (1994) 6369-6373
14. Hart S.R., Mangoni A.A., Swift C.G., and Jackson S.H.D. Effect of methionine loading on pulse wave analysis in elderly volunteers. Postgrad Med J 82 (2006) 524-527
15. Roberts D.H., Tsao Y., and Breckenridge A.M. The reproducibility of limb blood flow measurements in human volunteers at rest and after exercise by using mercury-in-Silastic strain gauge plethysmography under standardized conditions. Clin Sci (Lond) 70 6 (1986) 635-638
16. Rodgers G.M., and Conn M.T. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood 75 (1990) 895-901
17. Ceriello A., Taboga C., Tonutti L., Quagliaro L., Piconi L., and Bais B. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment. Circulation 106 (2002) 1211